CYCS | ENSG00000172115 | NCBI 54205

Details for: CYCS

Gene ID: 54205

Symbol: CYCS

Ensembl ID: ENSG00000172115

Description: cytochrome c, somatic

Associated with

Activation of caspases through apoptosome-mediated cleavage
(R-HSA-111459)
Apoptosis
(R-HSA-109581)
Apoptotic factor-mediated response
(R-HSA-111471)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cytochrome c-mediated apoptotic response
(R-HSA-111461)
Cytoprotection by hmox1
(R-HSA-9707564)
Detoxification of reactive oxygen species
(R-HSA-3299685)
Formation of apoptosome
(R-HSA-111458)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Metabolism
(R-HSA-1430728)
Mitochondrial biogenesis
(R-HSA-1592230)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Programmed cell death
(R-HSA-5357801)
Pyroptosis
(R-HSA-5620971)
Regulated necrosis
(R-HSA-5218859)
Regulation of the apoptosome activity
(R-HSA-9627069)
Release of apoptotic factors from the mitochondria
(R-HSA-111457)
Respiratory electron transport
(R-HSA-611105)
Respiratory electron transport, atp synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
(R-HSA-163200)
Rna polymerase ii transcription
(R-HSA-73857)
Smac(diablo)-mediated dissociation of iap:caspase complexes
(R-HSA-111464)
Smac (diablo) binds to iaps
(R-HSA-111463)
Smac, xiap-regulated apoptotic response
(R-HSA-111469)
The citric acid (tca) cycle and respiratory electron transport
(R-HSA-1428517)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional activation of mitochondrial biogenesis
(R-HSA-2151201)
Transcriptional regulation by tp53
(R-HSA-3700989)
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
(GO:0008635)
Apoptosome
(GO:0043293)
Cellular respiration
(GO:0045333)
Cytosol
(GO:0005829)
Electron transfer activity
(GO:0009055)
Heme binding
(GO:0020037)
Intrinsic apoptotic signaling pathway
(GO:0097193)
Metal ion binding
(GO:0046872)
Mitochondrial electron transport, cytochrome c to oxygen
(GO:0006123)
Mitochondrial electron transport, ubiquinol to cytochrome c
(GO:0006122)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial intermembrane space
(GO:0005758)
Mitochondrion
(GO:0005739)
Nucleus
(GO:0005634)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Protein binding
(GO:0005515)
Respirasome
(GO:0070469)

Other Information

Proteins

Cytochrome c

Genular Protein ID: 1323894510

Symbol: CYC_HUMAN

Name: Cytochrome c

UniProtKB Accession Codes:

P99999 A4D166 B2R4I1 P00001 Q6NUR2 Q6NX69 Q96BV4

Database IDs:

Citations:

PubMed ID: 2849112

Title: The human somatic cytochrome c gene: two classes of processed pseudogenes demarcate a period of rapid molecular evolution.

PubMed ID: 2849112

DOI: 10.1073/pnas.85.24.9625

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 13933734

Title: The amino acid sequence of human heart cytochrome c.

PubMed ID: 13933734

PubMed ID: 14063298

Title: Human heart cytochrome c. Chymotryptic peptides, tryptic peptides, and the complete amino acid sequence.

PubMed ID: 14063298

PubMed ID: 9515723

Title: Cytochrome c in the apoptotic and antioxidant cascades.

PubMed ID: 9515723

DOI: 10.1016/s0014-5793(98)00061-1

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23150584

Title: Human mitochondrial holocytochrome c synthase's heme binding, maturation determinants, and complex formation with cytochrome c.

PubMed ID: 23150584

DOI: 10.1073/pnas.1213897109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 18345000

Title: A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia.

PubMed ID: 18345000

DOI: 10.1038/ng.103

Sequence Information:

Length: 105
Mass: 11749
Checksum: 8EE9689E0102506B
Sequence:

MGDVEKGKKI FIMKCSQCHT VEKGGKHKTG PNLHGLFGRK TGQAPGYSYT AANKNKGIIW 
GEDTLMEYLE NPKKYIPGTK MIFVGIKKKE ERADLIAYLK KATNE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CYCS

Associated with

Other Information

The human somatic cytochrome c gene: two classes of processed pseudogenes demarcate a period of rapid molecular evolution. PubMed ID: 2849112

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence of human chromosome 7. PubMed ID: 12853948

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The amino acid sequence of human heart cytochrome c. PubMed ID: 13933734

Human heart cytochrome c. Chymotryptic peptides, tryptic peptides, and the complete amino acid sequence. PubMed ID: 14063298

Cytochrome c in the apoptotic and antioxidant cascades. PubMed ID: 9515723

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Human mitochondrial holocytochrome c synthase's heme binding, maturation determinants, and complex formation with cytochrome c. PubMed ID: 23150584

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia. PubMed ID: 18345000