TREM2 | ENSG00000095970 | NCBI 54209

Details for: TREM2

Gene ID: 54209

Symbol: TREM2

Ensembl ID: ENSG00000095970

Description: triggering receptor expressed on myeloid cells 2

Associated with

Adaptive immune system
(R-HSA-1280218)
Axon guidance
(R-HSA-422475)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Developmental biology
(R-HSA-1266738)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Innate immune system
(R-HSA-168249)
Nervous system development
(R-HSA-9675108)
Other semaphorin interactions
(R-HSA-416700)
Semaphorin interactions
(R-HSA-373755)
Amyloid-beta binding
(GO:0001540)
Apolipoprotein a-i binding
(GO:0034186)
Apolipoprotein binding
(GO:0034185)
Apoptotic cell clearance
(GO:0043277)
Astrocyte activation
(GO:0048143)
Beta-catenin binding
(GO:0008013)
Cxcl12-activated cxcr4 signaling pathway
(GO:0038160)
Defense response to gram-negative bacterium
(GO:0050829)
Detection of lipopolysaccharide
(GO:0032497)
Detection of peptidoglycan
(GO:0032499)
High-density lipoprotein particle binding
(GO:0008035)
Humoral immune response
(GO:0006959)
Kinase activator activity
(GO:0019209)
Lipid binding
(GO:0008289)
Lipid homeostasis
(GO:0055088)
Lipopolysaccharide binding
(GO:0001530)
Lipoprotein particle binding
(GO:0071813)
Lipoteichoic acid binding
(GO:0070891)
Low-density lipoprotein particle binding
(GO:0030169)
Memory
(GO:0007613)
Microglial cell activation
(GO:0001774)
Microglial cell activation involved in immune response
(GO:0002282)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of cell activation
(GO:0050866)
Negative regulation of cholesterol storage
(GO:0010887)
Negative regulation of glial cell apoptotic process
(GO:0034351)
Negative regulation of inflammatory response to antigenic stimulus
(GO:0002862)
Negative regulation of interleukin-1 beta production
(GO:0032691)
Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051898)
Negative regulation of sequestering of triglyceride
(GO:0010891)
Negative regulation of toll-like receptor 2 signaling pathway
(GO:0034136)
Negative regulation of toll-like receptor 4 signaling pathway
(GO:0034144)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Osteoclast differentiation
(GO:0030316)
Peptidoglycan binding
(GO:0042834)
Phagocytosis, engulfment
(GO:0006911)
Phagocytosis, recognition
(GO:0006910)
Phosphatidylethanolamine binding
(GO:0008429)
Phosphatidylserine binding
(GO:0001786)
Phospholipid binding
(GO:0005543)
Positive regulation of antigen processing and presentation of peptide antigen via mhc class ii
(GO:0002588)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Positive regulation of chemotaxis
(GO:0050921)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of complement activation, classical pathway
(GO:0045960)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of high-density lipoprotein particle clearance
(GO:0010983)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of macrophage fusion
(GO:0034241)
Positive regulation of mitochondrion organization
(GO:0010822)
Positive regulation of osteoclast differentiation
(GO:0045672)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of protein secretion
(GO:0050714)
Positive regulation of tor signaling
(GO:0032008)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein tyrosine kinase binding
(GO:1990782)
Regulation of gene expression
(GO:0010468)
Regulation of innate immune response
(GO:0045088)
Regulation of interleukin-6 production
(GO:0032675)
Regulation of lipid metabolic process
(GO:0019216)
Regulation of peptidyl-tyrosine phosphorylation
(GO:0050730)
Regulation of toll-like receptor 6 signaling pathway
(GO:0034151)
Regulation of tor signaling
(GO:0032006)
Respiratory burst after phagocytosis
(GO:0045728)
Response to axon injury
(GO:0048678)
Response to ischemia
(GO:0002931)
Scaffold protein binding
(GO:0097110)
Signaling receptor activity
(GO:0038023)
Social behavior
(GO:0035176)
Sulfatide binding
(GO:0120146)
Transmembrane signaling receptor activity
(GO:0004888)
Very-low-density lipoprotein particle binding
(GO:0034189)

Other Information

Proteins

Triggering receptor expressed on myeloid cells 2

Genular Protein ID: 2789579742

Symbol: TREM2_HUMAN

Name: Triggering receptor expressed on myeloid cells 2

UniProtKB Accession Codes:

Q9NZC2 Q8N5H8 Q8WYN6

Database IDs:

Citations:

PubMed ID: 10799849

Title: Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.

PubMed ID: 10799849

DOI: 10.4049/jimmunol.164.10.4991

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11602640

Title: A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells.

PubMed ID: 11602640

DOI: 10.1084/jem.194.8.1111

PubMed ID: 12080485

Title: Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype.

PubMed ID: 12080485

DOI: 10.1086/342259

PubMed ID: 12925681

Title: DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features.

PubMed ID: 12925681

DOI: 10.1084/jem.20030027

PubMed ID: 15883308

Title: The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2.

PubMed ID: 15883308

DOI: 10.1212/01.wnl.0000160304.00003.ca

PubMed ID: 18957693

Title: Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.

PubMed ID: 18957693

DOI: 10.1126/scisignal.1159665

PubMed ID: 25957402

Title: DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response.

PubMed ID: 25957402

DOI: 10.1074/jbc.m115.645986

PubMed ID: 24078628

Title: Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and gamma-secretase-dependent intramembranous cleavage.

PubMed ID: 24078628

DOI: 10.1074/jbc.m113.517540

PubMed ID: 24990881

Title: TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.

PubMed ID: 24990881

DOI: 10.1126/scitranslmed.3009093

PubMed ID: 27589997

Title: Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression.

PubMed ID: 27589997

DOI: 10.1186/s40478-016-0367-7

PubMed ID: 27067662

Title: A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese.

PubMed ID: 27067662

DOI: 10.1016/j.neurobiolaging.2016.02.023

PubMed ID: 27477018

Title: TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

PubMed ID: 27477018

DOI: 10.1016/j.neuron.2016.06.015

PubMed ID: 28802038

Title: TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.

PubMed ID: 28802038

DOI: 10.1016/j.cell.2017.07.023

PubMed ID: 28855300

Title: An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.

PubMed ID: 28855300

DOI: 10.15252/emmm.201707672

PubMed ID: 28855301

Title: TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.

PubMed ID: 28855301

DOI: 10.15252/emmm.201707673

PubMed ID: 28768830

Title: Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment.

PubMed ID: 28768830

DOI: 10.1091/mbc.e17-06-0423

PubMed ID: 30442540

Title: Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2.

PubMed ID: 30442540

DOI: 10.1016/j.jalz.2018.09.006

PubMed ID: 29752066

Title: The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.

PubMed ID: 29752066

DOI: 10.1016/j.immuni.2018.04.016

PubMed ID: 29518356

Title: TREM2 Is a Receptor for beta-Amyloid that Mediates Microglial Function.

PubMed ID: 29518356

DOI: 10.1016/j.neuron.2018.01.031

PubMed ID: 27995897

Title: Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.

PubMed ID: 27995897

DOI: 10.7554/elife.20391

PubMed ID: 29794134

Title: Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.

PubMed ID: 29794134

DOI: 10.1074/jbc.ra118.002352

PubMed ID: 12754369

Title: An Italian family affected by Nasu-Hakola disease with a novel genetic mutation in the TREM2 gene.

PubMed ID: 12754369

DOI: 10.1136/jnnp.74.6.825-a

PubMed ID: 23399524

Title: Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy (PLOSL): a new report of an Italian woman and review of the literature.

PubMed ID: 23399524

DOI: 10.1016/j.jns.2013.01.021

PubMed ID: 25615530

Title: Disease-associated mutations of TREM2 alter the processing of N-linked oligosaccharides in the Golgi apparatus.

PubMed ID: 25615530

DOI: 10.1111/tra.12264

PubMed ID: 29142083

Title: Evidence of CNS beta-amyloid deposition in Nasu-Hakola disease due to the TREM2 Q33X mutation.

PubMed ID: 29142083

DOI: 10.1212/wnl.0000000000004747

Sequence Information:

Length: 230
Mass: 25447
Checksum: C894AA210F708AF7
Sequence:

MEPLRLLILL FVTELSGAHN TTVFQGVAGQ SLQVSCPYDS MKHWGRRKAW CRQLGEKGPC 
QRVVSTHNLW LLSFLRRWNG STAITDDTLG GTLTITLRNL QPHDAGLYQC QSLHGSEADT 
LRKVLVEVLA DPLDHRDAGD LWFPGESESF EDAHVEHSIS RSLLEGEIPF PPTSILLLLA 
CIFLIKILAA SALWAAAWHG QKPGTHPPSE LDCGHDPGYQ LQTLPGLRDT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TREM2

Associated with

Other Information

Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. PubMed ID: 10799849

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells. PubMed ID: 11602640

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. PubMed ID: 12080485

DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features. PubMed ID: 12925681

The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2. PubMed ID: 15883308

Essential role of DAP12 signaling in macrophage programming into a fusion-competent state. PubMed ID: 18957693

DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response. PubMed ID: 25957402

Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and gamma-secretase-dependent intramembranous cleavage. PubMed ID: 24078628

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. PubMed ID: 24990881

Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression. PubMed ID: 27589997

A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese. PubMed ID: 27067662

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. PubMed ID: 27477018

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. PubMed ID: 28802038

An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. PubMed ID: 28855300

TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant. PubMed ID: 28855301

Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment. PubMed ID: 28768830

Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2. PubMed ID: 30442540

The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity. PubMed ID: 29752066

TREM2 Is a Receptor for beta-Amyloid that Mediates Microglial Function. PubMed ID: 29518356

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms. PubMed ID: 27995897

Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2. PubMed ID: 29794134

An Italian family affected by Nasu-Hakola disease with a novel genetic mutation in the TREM2 gene. PubMed ID: 12754369

Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy (PLOSL): a new report of an Italian woman and review of the literature. PubMed ID: 23399524

Disease-associated mutations of TREM2 alter the processing of N-linked oligosaccharides in the Golgi apparatus. PubMed ID: 25615530

Evidence of CNS beta-amyloid deposition in Nasu-Hakola disease due to the TREM2 Q33X mutation. PubMed ID: 29142083