Details for: App

Gene ID: 54226

Symbol: App

Ensembl ID: ENSRNOG00000006997

Description: amyloid beta precursor protein

Associated with

Other Information

Genular Protein ID: 953884735

Symbol: A4_RAT

Name: ABPP

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2900758

Title: Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.

PubMed ID: 2900758

DOI: 10.1002/j.1460-2075.1988.tb02952.x

PubMed ID: 2968652

Title: Amyloid beta protein precursor is possibly a heparan sulfate proteoglycan core protein.

PubMed ID: 2968652

DOI: 10.1126/science.2968652

PubMed ID: 1673681

Title: Purification and tissue level of the beta-amyloid peptide precursor of rat brain.

PubMed ID: 1673681

DOI: 10.1016/s0021-9258(18)92997-2

PubMed ID: 2648331

Title: The sequence of the two extra exons in rat preA4.

PubMed ID: 2648331

DOI: 10.1093/nar/17.5.2130

PubMed ID: 11483588

Title: Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch.

PubMed ID: 11483588

DOI: 10.1074/jbc.c100357200

PubMed ID: 8624099

Title: APP gene family. Alternative splicing generates functionally related isoforms.

PubMed ID: 8624099

DOI: 10.1111/j.1749-6632.1996.tb34433.x

PubMed ID: 7744833

Title: The Alzheimer amyloid precursor proteoglycan (appican) is present in brain and is produced by astrocytes but not by neurons in primary neural cultures.

PubMed ID: 7744833

DOI: 10.1074/jbc.270.20.11839

PubMed ID: 8996834

Title: Expression of the APP gene family in brain cells, brain development and aging.

PubMed ID: 8996834

DOI: 10.1159/000213840

PubMed ID: 9930726

Title: A 127-kDa protein (UV-DDB) binds to the cytoplasmic domain of the Alzheimer's amyloid precursor protein.

PubMed ID: 9930726

DOI: 10.1046/j.1471-4159.1999.0720549.x

PubMed ID: 10024358

Title: The amyloid precursor protein interacts with Go heterotrimeric protein within a cell compartment specialized in signal transduction.

PubMed ID: 10024358

DOI: 10.1523/jneurosci.19-05-01717.1999

PubMed ID: 7913895

Title: The beta A4 amyloid precursor protein binding to copper.

PubMed ID: 7913895

DOI: 10.1016/0014-5793(94)00658-x

PubMed ID: 7737970

Title: The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene.

PubMed ID: 7737970

DOI: 10.1074/jbc.270.18.10388

PubMed ID: 10386999

Title: The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction.

PubMed ID: 10386999

DOI: 10.1021/bi990438f

PubMed ID: 10413512

Title: Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's disease.

PubMed ID: 10413512

DOI: 10.1021/bi990205o

PubMed ID: 11959460

Title: Role of glycine-33 and methionine-35 in Alzheimer's amyloid-beta peptide 1-42-associated oxidative stress and neurotoxicity.

PubMed ID: 11959460

DOI: 10.1016/s0925-4439(01)00097-7

PubMed ID: 9085254

Title: The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.

PubMed ID: 9085254

DOI: 10.1007/bf03401803

PubMed ID: 10329382

Title: Phosphorylation of the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein at Ser655 by a novel protein kinase.

PubMed ID: 10329382

DOI: 10.1006/bbrc.1999.0637

PubMed ID: 10341243

Title: Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation.

PubMed ID: 10341243

DOI: 10.1523/jneurosci.19-11-04421.1999

PubMed ID: 10936190

Title: Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.

PubMed ID: 10936190

DOI: 10.1046/j.1471-4159.2000.0751085.x

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 23011729

Title: Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon.

PubMed ID: 23011729

DOI: 10.1088/1478-3975/9/5/055005

PubMed ID: 22847417

Title: Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688.

PubMed ID: 22847417

DOI: 10.1073/pnas.1206786109

PubMed ID: 26479776

Title: Peptidomics for studying limited proteolysis.

PubMed ID: 26479776

DOI: 10.1021/acs.jproteome.5b00820

PubMed ID: 11479316

Title: Appican, the proteoglycan form of the amyloid precursor protein, contains chondroitin sulfate E in the repeating disaccharide region and 4-O-sulfated galactose in the linkage region.

PubMed ID: 11479316

DOI: 10.1074/jbc.m105818200

Sequence Information:

  • Length: 770
  • Mass: 86704
  • Checksum: C26C9D6BB2D929A7
  • Sequence:
  • MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG KWESDPSGTK 
    TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHTH IVIPYRCLVG 
    EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR 
    GVEFVCCPLA EESDSIDSAD AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE 
    EAEDDEDVED GDEVEEEAEE PYEEATERTT SIATTTTTTT ESVEEVVREV CSEQAETGPC 
    RAMISRWYFD VTEGKCAPFF YGGCGGNRNN FDTEEYCMAV CGSVSSQSLL KTTSEPLPQD 
    PVKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM REWEEAERQA 
    KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR LALENYITAL 
    QAVPPRPHHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER 
    MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET 
    KTTVELLPVN GEFSLDDLQP WHPFGVDSVP ANTENEVEPV DARPAADRGL TTRPGSGLTN 
    IKTEEISEVK MDAEFGHDSG FEVRHQKLVF FAEDVGSNKG AIIGLMVGGV VIATVIVITL 
    VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN

Genular Protein ID: 2614407740

Symbol: A0A8I5Y8G9_RAT

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

  • Length: 752
  • Mass: 84801
  • Checksum: D080DA8E1DE4A6E6
  • Sequence:
  • MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG KWESDPSGTK 
    TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHTH IVIPYRCLVG 
    EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR 
    GVEFVCCPLA EESDSIDSAD AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE 
    EAEDDEDVED GDEVEEEAEE PYEEATERTT SIATTTTTTT ESVEEVVREV CSEQAETGPC 
    RAMISRWYFD VTEGKCAPFF YGGCGGNRNN FDTEEYCMAV CGSVSSQSLL KTTSEPLPQD 
    PVKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM REWEEAERQA 
    KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR LALENYITAL 
    QAVPPRPHHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER 
    MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET 
    KTTVELLPVN GEFSLDDLQP WHPFGVDSVP ANTENEGSGL TNIKTEEISE VKMDAEFGHD 
    SGFEVRHQKL VFFAEDVGSN KGAIIGLMVG GVVIATVIVI TLVMLKKKQY TSIHHGVVEV 
    DAAVTPEERH LSKMQQNGYE NPTYKFFEQM QN

Genular Protein ID: 2711734196

Symbol: A6JL61_RAT

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 695
  • Mass: 78483
  • Checksum: 61D21E1E941972DC
  • Sequence:
  • MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG KWESDPSGTK 
    TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHTH IVIPYRCLVG 
    EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR 
    GVEFVCCPLA EESDSIDSAD AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE 
    EAEDDEDVED GDEVEEEAEE PYEEATERTT SIATTTTTTT ESVEEVVRVP TTAASTPDAV 
    DKYLETPGDE NEHAHFQKAK ERLEAKHRER MSQVMREWEE AERQAKNLPK ADKKAVIQHF 
    QEKVESLEQE AANERQQLVE THMARVEAML NDRRRLALEN YITALQAVPP RPHHVFNMLK 
    KYVRAEQKDR QHTLKHFEHV RMVDPKKAAQ IRSQVMTHLR VIYERMNQSL SLLYNVPAVA 
    EEIQDEVDEL LQKEQNYSDD VLANMISEPR ISYGNDALMP SLTETKTTVE LLPVNGEFSL 
    DDLQPWHPFG VDSVPANTEN EVEPVDARPA ADRGLTTRPG SGLTNIKTEE ISEVKMDAEF 
    GHDSGFEVRH QKLVFFAEDV GSNKGAIIGL MVGGVVIATV IVITLVMLKK KQYTSIHHGV 
    VEVDAAVTPE ERHLSKMQQN GYENPTYKFF EQMQN

Genular Protein ID: 3166606261

Symbol: Q6P6Q5_RAT

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

Sequence Information:

  • Length: 733
  • Mass: 82798
  • Checksum: 8538F36FF73762F1
  • Sequence:
  • MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG KWESDPSGTK 
    TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHTH IVIPYRCLVG 
    EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR 
    GVEFVCCPLA EESDSIDSAD AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE 
    EAEDDEDVED GDEVEEEAEE PYEEATERTT SIATTTTTTT ESVEEVVREV CSEQAETGPC 
    RAMISRWYFD VTEGKCAPFF YGGCGGNRNN FDTEEYCMAV CGSVFPTTAA STPDAVDKYL 
    ETPGDENEHA HFQKAKERLE AKHRERMSQV MREWEEAERQ AKNLPKADKK AVIQHFQEKV 
    ESLEQEAANE RQQLVETHMA RVEAMLNDRR RLALENYITA LQAVPPRPHH VFNMLKKYVR 
    AEQKDRQHTL KHFEHVRMVD PKKAAQIRSQ VMTHLRVIYE RMNQSLSLLY NVPAVAEEIQ 
    DEVDELLQKE QNYSDDVLAN MISEPRISYG NDALMPSLTE TKTTVELLPV NGEFSLDDLQ 
    PWHPFGVDSV PANTENEGSG LTNIKTEEIS EVKMDAEFGH DSGFEVRHQK LVFFAEDVGS 
    NKGAIIGLMV GGVVIATVIV ITLVMLKKKQ YTSIHHGVVE VDAAVTPEER HLSKMQQNGY 
    ENPTYKFFEQ MQN

Genular Protein ID: 2256629270

Symbol: A0A0H2UHW9_RAT

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

Sequence Information:

  • Length: 751
  • Mass: 84701
  • Checksum: 20EDABEEC9CEDF81
  • Sequence:
  • MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG KWESDPSGTK 
    TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHTH IVIPYRCLVG 
    EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR 
    GVEFVCCPLA EESDSIDSAD AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE 
    EAEDDEDVED GDEVEEEAEE PYEEATERTT SIATTTTTTT ESVEEVVREV CSEQAETGPC 
    RAMISRWYFD VTEGKCAPFF YGGCGGNRNN FDTEEYCMAV CGSVFPTTAA STPDAVDKYL 
    ETPGDENEHA HFQKAKERLE AKHRERMSQV MREWEEAERQ AKNLPKADKK AVIQHFQEKV 
    ESLEQEAANE RQQLVETHMA RVEAMLNDRR RLALENYITA LQAVPPRPHH VFNMLKKYVR 
    AEQKDRQHTL KHFEHVRMVD PKKAAQIRSQ VMTHLRVIYE RMNQSLSLLY NVPAVAEEIQ 
    DEVDELLQKE QNYSDDVLAN MISEPRISYG NDALMPSLTE TKTTVELLPV NGEFSLDDLQ 
    PWHPFGVDSV PANTENEVEP VDARPAADRG LTTRPGSGLT NIKTEEISEV KMDAEFGHDS 
    GFEVRHQKLV FFAEDVGSNK GAIIGLMVGG VVIATVIVIT LVMLKKKQYT SIHHGVVEVD 
    AAVTPEERHL SKMQQNGYEN PTYKFFEQMQ N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.