Arc | ENSRNOG00000043465 | NCBI 54323

Details for: Arc

Gene ID: 54323

Symbol: Arc

Ensembl ID: ENSRNOG00000043465

Description: activity-regulated cytoskeleton-associated protein

Associated with

Acrosomal vesicle
(GO:0001669)
Actin cytoskeleton
(GO:0015629)
Anterior/posterior pattern specification
(GO:0009952)
Cell cortex
(GO:0005938)
Cell migration
(GO:0016477)
Clathrin-coated vesicle membrane
(GO:0030665)
Cytoplasm
(GO:0005737)
Cytoskeleton organization
(GO:0007010)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Dendritic spine
(GO:0043197)
Early endosome membrane
(GO:0031901)
Endocytosis
(GO:0006897)
Endoderm development
(GO:0007492)
Extracellular vesicle
(GO:1903561)
Glutamatergic synapse
(GO:0098978)
Learning
(GO:0007612)
Long-term memory
(GO:0007616)
Membrane raft
(GO:0045121)
Modulation of chemical synaptic transmission
(GO:0050804)
Mrna binding
(GO:0003729)
Mrna transport
(GO:0051028)
Neuronal ribonucleoprotein granule
(GO:0071598)
Plasma membrane
(GO:0005886)
Postsynaptic density membrane
(GO:0098839)
Postsynaptic endosome
(GO:0098845)
Protein binding
(GO:0005515)
Protein homooligomerization
(GO:0051260)
Regulation of cell morphogenesis
(GO:0022604)
Regulation of dendritic spine morphogenesis
(GO:0061001)
Regulation of long-term synaptic depression
(GO:1900452)
Regulation of long-term synaptic potentiation
(GO:1900271)
Regulation of neuronal synaptic plasticity
(GO:0048168)
Regulation of postsynaptic neurotransmitter receptor internalization
(GO:0099149)
Response to ethanol
(GO:0045471)
Response to morphine
(GO:0043278)
Vesicle-mediated intercellular transport
(GO:0110077)

Other Information

Proteins

ARC_RAT

Genular Protein ID: 3367135023

Symbol: ARC_RAT

Name: N/A

UniProtKB Accession Codes:

Q63053 Q62743

Database IDs:

Citations:

PubMed ID: 7857651

Title: Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites.

PubMed ID: 7857651

DOI: 10.1016/0896-6273(95)90299-6

PubMed ID: 7777577

Title: Somatodendritic expression of an immediate early gene is regulated by synaptic activity.

PubMed ID: 7777577

DOI: 10.1073/pnas.92.12.5734

PubMed ID: 9808461

Title: Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites.

PubMed ID: 9808461

DOI: 10.1016/s0896-6273(00)80591-7

PubMed ID: 10570490

Title: Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles.

PubMed ID: 10570490

DOI: 10.1038/16046

PubMed ID: 10818134

Title: Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory.

PubMed ID: 10818134

DOI: 10.1523/jneurosci.20-11-03993.2000

PubMed ID: 11226315

Title: Internal initiation of translation of five dendritically localized neuronal mRNAs.

PubMed ID: 11226315

DOI: 10.1073/pnas.051623398

PubMed ID: 17088211

Title: Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking.

PubMed ID: 17088211

DOI: 10.1016/j.neuron.2006.08.033

PubMed ID: 17088212

Title: Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission.

PubMed ID: 17088212

DOI: 10.1016/j.neuron.2006.09.031

PubMed ID: 17088213

Title: Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA Receptors.

PubMed ID: 17088213

DOI: 10.1016/j.neuron.2006.08.034

PubMed ID: 18614031

Title: Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate.

PubMed ID: 18614031

DOI: 10.1016/j.neuron.2008.05.014

PubMed ID: 22579289

Title: Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIbeta.

PubMed ID: 22579289

DOI: 10.1016/j.cell.2012.02.062

PubMed ID: 23791196

Title: Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum.

PubMed ID: 23791196

DOI: 10.1016/j.neuron.2013.04.036

PubMed ID: 29328916

Title: The neuronal gene Arc encodes a repurposed retrotransposon Gag protein that mediates intercellular RNA transfer.

PubMed ID: 29328916

DOI: 10.1016/j.cell.2017.12.024

PubMed ID: 30028513

Title: Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities.

PubMed ID: 30028513

DOI: 10.1111/jnc.14556

PubMed ID: 25864631

Title: Structural basis of arc binding to synaptic proteins: implications for cognitive disease.

PubMed ID: 25864631

DOI: 10.1016/j.neuron.2015.03.030

PubMed ID: 31080121

Title: The capsid domain of Arc changes its oligomerization propensity through direct interaction with the NMDA receptor.

PubMed ID: 31080121

DOI: 10.1016/j.str.2019.04.001

Sequence Information:

Length: 396
Mass: 45353
Checksum: 4E95B46B75853CA5
Sequence:

MELDHMTTGG LHAYPAPRGG PAAKPNVILQ IGKCRAEMLE HVRRTHRHLL TEVSKQVERE 
LKGLHRSVGK LENNLDGYVP TGDSQRWKKS IKACLCRCQE TIANLERWVK REMHVWREVF 
YRLERWADRL ESMGGKYPVG SEPARHTVSV GVGGPEPYCQ EADGYDYTVS PYAITPPPAA 
GELPEQESVG AQQYQSWVPG EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS 
QIQNHMNGPA KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELDL PQKQGEPLDQ 
FLWRKRDLYQ TLYVDAEEEE IIQYVVGTLQ PKFKRFLRHP LPKTLEQLIQ RGMEVQDGLE 
QAAEPSVTPL PTEDETEALT PALTSESVAS DRTQPE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Arc

Associated with

Other Information

Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. PubMed ID: 7857651

Somatodendritic expression of an immediate early gene is regulated by synaptic activity. PubMed ID: 7777577

Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites. PubMed ID: 9808461

Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles. PubMed ID: 10570490

Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. PubMed ID: 10818134

Internal initiation of translation of five dendritically localized neuronal mRNAs. PubMed ID: 11226315

Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. PubMed ID: 17088211

Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission. PubMed ID: 17088212

Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA Receptors. PubMed ID: 17088213

Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate. PubMed ID: 18614031

Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIbeta. PubMed ID: 22579289

Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum. PubMed ID: 23791196

The neuronal gene Arc encodes a repurposed retrotransposon Gag protein that mediates intercellular RNA transfer. PubMed ID: 29328916

Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities. PubMed ID: 30028513

Structural basis of arc binding to synaptic proteins: implications for cognitive disease. PubMed ID: 25864631

The capsid domain of Arc changes its oligomerization propensity through direct interaction with the NMDA receptor. PubMed ID: 31080121