Irgm2 | ENSMUSG00000069874 | NCBI 54396

Details for: Irgm2

Gene ID: 54396

Symbol: Irgm2

Ensembl ID: ENSMUSG00000069874

Description: immunity-related GTPase family M member 2

Associated with

Autophagosome assembly
(GO:0000045)
Autophagosome membrane
(GO:0000421)
Bh3 domain binding
(GO:0051434)
Camkk-ampk signaling cascade
(GO:0061762)
Card domain binding
(GO:0050700)
Cardiolipin binding
(GO:1901612)
Cellular response to interferon-beta
(GO:0035458)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to virus
(GO:0098586)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Defense response
(GO:0006952)
Defense response to bacterium
(GO:0042742)
Defense response to gram-negative bacterium
(GO:0050829)
Defense response to protozoan
(GO:0042832)
Endoplasmic reticulum membrane
(GO:0005789)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
G protein activity
(GO:0003925)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Hydrolase activity
(GO:0016787)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Killing of cells of another organism
(GO:0031640)
Membrane
(GO:0016020)
Mitochondrion
(GO:0005739)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of cgas/sting signaling pathway
(GO:0160049)
Negative regulation of defense response to virus
(GO:0050687)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of nlrp3 inflammasome complex assembly
(GO:1900226)
Negative regulation of non-canonical inflammasome complex assembly
(GO:0160076)
Negative regulation of type i interferon production
(GO:0032480)
Nucleotide-binding oligomerization domain containing 2 signaling pathway
(GO:0070431)
Nucleotide binding
(GO:0000166)
Positive regulation of autophagosome maturation
(GO:1901098)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of lysosome organization
(GO:1905673)
Positive regulation of mitochondrial fission
(GO:0090141)
Positive regulation of mitophagy
(GO:1901526)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of protein serine/threonine kinase activity
(GO:0071902)
Positive regulation of type ii interferon-mediated signaling pathway
(GO:0060335)
Positive regulation of xenophagy
(GO:1904417)
Protein-containing complex assembly
(GO:0065003)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein destabilization
(GO:0031648)
Protein kinase binding
(GO:0019901)
Protein lipidation involved in autophagosome assembly
(GO:0061739)
Protein serine/threonine kinase activator activity
(GO:0043539)
Protein stabilization
(GO:0050821)
Protein targeting to vacuolar membrane
(GO:0044395)
Protein targeting to vacuole involved in autophagy
(GO:0071211)
Regulation of protein-containing complex assembly
(GO:0043254)
Regulation of protein complex stability
(GO:0061635)
Response to bacterium
(GO:0009617)
Vacuolar membrane
(GO:0005774)

Other Information

Proteins

IRGM2_MOUSE

Genular Protein ID: 3546885597

Symbol: IRGM2_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A140LIF8 E9PVI2 Q3TAN6 Q3TNE5 Q3U635 Q9Z1M2

Database IDs:

Citations:

PubMed ID: 9862701

Title: Two families of GTPases dominate the complex cellular response to IFN-gamma.

PubMed ID: 9862701

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 22892676

Title: Comparative genomic analysis of eutherian interferon-gamma-inducible GTPases.

PubMed ID: 22892676

DOI: 10.1007/s10142-012-0291-2

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 17641048

Title: The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia psittaci infection.

PubMed ID: 17641048

DOI: 10.4049/jimmunol.179.3.1814

PubMed ID: 33124769

Title: Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response.

PubMed ID: 33124769

DOI: 10.15252/embr.202050829

PubMed ID: 33124745

Title: Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock.

PubMed ID: 33124745

DOI: 10.15252/embr.202050830

PubMed ID: 34338548

Title: Murine Irgm paralogs regulate nonredundant functions to execute host defense to Toxoplasma gondii.

PubMed ID: 34338548

DOI: 10.1128/iai.00202-21

PubMed ID: 34078740

Title: Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization.

PubMed ID: 34078740

DOI: 10.26508/lsa.202000960

PubMed ID: 36629440

Title: Differential requirement for IRGM proteins during Tuberculosis infection in mice.

PubMed ID: 36629440

DOI: 10.1128/iai.00510-22

Sequence Information:

Length: 395
Mass: 45205
Checksum: 5B66E97CD46E1A85
Sequence:

MEEAVESPEV KEFEYFSDAV FIPKDGNTLS VGVIKRIETA VKEGEVVKVV SIVKEIIQNV 
SRNKIKIAVT GDSGNGMSSF INALRLIGHE EKDSAPTGVV RTTQKPTCYF SSHFPYVELW 
DLPGLGATAQ SVESYLEEMQ ISIYDLIIIV ASEQFSLNHV KLAITMQRMR KRFYVVWTKL 
DRDLSTSTFP EPQLLQSIQR NIRDSLQKEK VKEHPMFLVS VFKPESHDFP KLRETLQKDL 
PVIKYHGLVE TLYQVCEKTV NERVESIKKS IDEDNLHTEF GISDPGNAIE IRKAFQKTFG 
LDDISLHLVA LEMKNKHFNT SMESQETQRY QQDDWVLARL YRTGTRVGSI GFDYMKCCFT 
SHHSRCKQQK DILDETAAKA KEVLLKILRL SIPHP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Irgm2

Associated with

Other Information

Two families of GTPases dominate the complex cellular response to IFN-gamma. PubMed ID: 9862701

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Comparative genomic analysis of eutherian interferon-gamma-inducible GTPases. PubMed ID: 22892676

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia psittaci infection. PubMed ID: 17641048

Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response. PubMed ID: 33124769

Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock. PubMed ID: 33124745

Murine Irgm paralogs regulate nonredundant functions to execute host defense to Toxoplasma gondii. PubMed ID: 34338548

Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization. PubMed ID: 34078740

Differential requirement for IRGM proteins during Tuberculosis infection in mice. PubMed ID: 36629440