Dnmt3l | ENSMUSG00000000730 | NCBI 54427

Details for: Dnmt3l

Gene ID: 54427

Symbol: Dnmt3l

Ensembl ID: ENSMUSG00000000730

Description: DNA methyltransferase 3-like

Associated with

Autosome genomic imprinting
(GO:0141068)
C-5 methylation of cytosine
(GO:0090116)
Catalytic complex
(GO:1902494)
Cell differentiation
(GO:0030154)
Chorionic trophoblast cell differentiation
(GO:0060718)
Condensed nuclear chromosome
(GO:0000794)
Cytoplasm
(GO:0005737)
Dna (cytosine-5-)-methyltransferase activity
(GO:0003886)
Dna (cytosine-5-)-methyltransferase activity, acting on cpg substrates
(GO:0051718)
Dna binding
(GO:0003677)
Dna methylation
(GO:0006306)
Dna methylation-dependent heterochromatin formation
(GO:0006346)
Enzyme activator activity
(GO:0008047)
Enzyme binding
(GO:0019899)
Epigenetic programing of female pronucleus
(GO:0044726)
Esc/e(z) complex
(GO:0035098)
Genomic imprinting
(GO:0071514)
Heterochromatin
(GO:0000792)
Male meiosis i
(GO:0007141)
Metal ion binding
(GO:0046872)
Methylation
(GO:0032259)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of dna methylation-dependent heterochromatin formation
(GO:0090310)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Placenta development
(GO:0001890)
Protein binding
(GO:0005515)
Regulation of gene expression
(GO:0010468)
Retrotransposon silencing by heterochromatin formation
(GO:0141005)
S-adenosylmethionine-dependent methyltransferase activity
(GO:0008757)
Spermatogenesis
(GO:0007283)
Stem cell differentiation
(GO:0048863)

Other Information

Proteins

DNA (cytosine-5)-methyltransferase 3-like
D3YUQ4_MOUSE

Genular Protein ID: 705019410

Symbol: DNM3L_MOUSE

Name: DNA (cytosine-5)-methyltransferase 3-like

UniProtKB Accession Codes:

Q9CWR8

Database IDs:

Citations:

PubMed ID: 11306809

Title: Isolation and initial characterization of the mouse Dnmt3l gene.

PubMed ID: 11306809

DOI: 10.1159/000056881

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11719692

Title: Dnmt3L and the establishment of maternal genomic imprints.

PubMed ID: 11719692

DOI: 10.1126/science.1065848

PubMed ID: 15318244

Title: Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L.

PubMed ID: 15318244

DOI: 10.1038/nature02886

PubMed ID: 15671018

Title: Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L.

PubMed ID: 15671018

DOI: 10.1074/jbc.m413412200

PubMed ID: 24074865

Title: Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs.

PubMed ID: 24074865

DOI: 10.1016/j.cell.2013.08.056

PubMed ID: 18945701

Title: Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L.

PubMed ID: 18945701

DOI: 10.1093/nar/gkn747

PubMed ID: 32674113

Title: SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation.

PubMed ID: 32674113

DOI: 10.1038/s41586-020-2557-5

Sequence Information:

Length: 421
Mass: 47993
Checksum: 6C996D220C6F6D83
Sequence:

MGSRETPSSC SKTLETLDLE TSDSSSPDAD SPLEEQWLKS SPALKEDSVD VVLEDCKEPL 
SPSSPPTGRE MIRYEVKVNR RSIEDICLCC GTLQVYTRHP LFEGGLCAPC KDKFLESLFL 
YDDDGHQSYC TICCSGGTLF ICESPDCTRC YCFECVDILV GPGTSERINA MACWVCFLCL 
PFSRSGLLQR RKRWRHQLKA FHDQEGAGPM EIYKTVSAWK RQPVRVLSLF RNIDKVLKSL 
GFLESGSGSG GGTLKYVEDV TNVVRRDVEK WGPFDLVYGS TQPLGSSCDR CPGWYMFQFH 
RILQYALPRQ ESQRPFFWIF MDNLLLTEDD QETTTRFLQT EAVTLQDVRG RDYQNAMRVW 
SNIPGLKSKH APLTPKEEEY LQAQVRSRSK LDAPKVDLLV KNCLLPLREY FKYFSQNSLP 
L

Genular Protein ID: 1938933015

Symbol: D3YUQ4_MOUSE

Name: N/A

UniProtKB Accession Codes:

D3YUQ4

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 126
Mass: 15038
Checksum: F399A0A121BDB5F6
Sequence:

MFQFHRILQY ALPRQESQRP FFWIFMDNLL LTEDDQETTT RFLQTEAVTL QDVRGRDYQN 
AMRVWSNIPG LKSKHAPLTP KEEEYLQAQV RSRSKLDAPK VDLLVKNCLL PLREYFKYFS 
QNSLPL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Dnmt3l

Associated with

Other Information

Isolation and initial characterization of the mouse Dnmt3l gene. PubMed ID: 11306809

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Dnmt3L and the establishment of maternal genomic imprints. PubMed ID: 11719692

Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. PubMed ID: 15318244

Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L. PubMed ID: 15671018

Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs. PubMed ID: 24074865

Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. PubMed ID: 18945701

SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation. PubMed ID: 32674113

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303