Asah2 | ENSMUSG00000024887 | NCBI 54447

Details for: Asah2

Gene ID: 54447

Symbol: Asah2

Ensembl ID: ENSMUSG00000024887

Description: N-acylsphingosine amidohydrolase 2

Associated with

Glycosphingolipid catabolism
(R-MMU-9840310)
Glycosphingolipid metabolism
(R-MMU-1660662)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Sphingolipid metabolism
(R-MMU-428157)
Apoptotic process
(GO:0006915)
Calcium ion binding
(GO:0005509)
Caveola
(GO:0005901)
Ceramidase activity
(GO:0102121)
Ceramide biosynthetic process
(GO:0046513)
Ceramide catabolic process
(GO:0046514)
Dihydroceramidase activity
(GO:0071633)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Hydrolase activity
(GO:0016787)
Lipid digestion
(GO:0044241)
Lipid metabolic process
(GO:0006629)
Long-chain fatty acid biosynthetic process
(GO:0042759)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
N-acylsphingosine amidohydrolase activity
(GO:0017040)
Phytoceramidase activity
(GO:0070774)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Response to organic substance
(GO:0010033)
Sphingolipid metabolic process
(GO:0006665)
Sphingosine biosynthetic process
(GO:0046512)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Acylsphingosine deacylase 2

Genular Protein ID: 1703680237

Symbol: ASAH2_MOUSE

Name: Acylsphingosine deacylase 2

UniProtKB Accession Codes:

Q9JHE3 Q3UWP9 Q8BNP0 Q8BQN7 Q8R236

Database IDs:

Citations:

PubMed ID: 10753931

Title: Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases.

PubMed ID: 10753931

DOI: 10.1074/jbc.275.15.11229

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10652340

Title: Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.

PubMed ID: 10652340

DOI: 10.1074/jbc.275.5.3462

PubMed ID: 11591392

Title: Localization of neutral ceramidase in caveolin-enriched light membranes of murine endothelial cells.

PubMed ID: 11591392

DOI: 10.1016/s0014-5793(01)02878-2

PubMed ID: 12921776

Title: Neutral ceramidase secreted by endothelial cells is released in part associated with caveolin-1.

PubMed ID: 12921776

DOI: 10.1016/s0003-9861(03)00212-1

PubMed ID: 14557071

Title: Neutral ceramidase gene: role in regulating ceramide-induced apoptosis.

PubMed ID: 14557071

DOI: 10.1016/s0378-1119(03)00721-2

PubMed ID: 16126722

Title: Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu.

PubMed ID: 16126722

DOI: 10.1074/jbc.m506827200

PubMed ID: 16380386

Title: Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids.

PubMed ID: 16380386

DOI: 10.1074/jbc.m508382200

PubMed ID: 21613224

Title: Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA.

PubMed ID: 21613224

DOI: 10.1074/jbc.m110.214866

Sequence Information:

Length: 756
Mass: 83509
Checksum: FFD514E51280D4BE
Sequence:

MAKRTFSTLE AFLIFLLVIM TVITVALLTL LFVTSGTIEN HKDSGNHWFS TTLGSTTTQP 
PPITQTPNFP SFRNFSGYYI GVGRADCTGQ VSDINLMGYG KNGQNARGLL TRLFSRAFIL 
ADPDGSNRMA FVSVELCMIS QRLRLEVLKR LESKYGSLYR RDNVILSAIH THSGPAGFFQ 
YTLYILASEG FSNRTFQYIV SGIMKSIDIA HTNLKPGKIF INKGNVANVQ INRSPSSYLL 
NPQSERARYS SNTDKEMLVL KLVDLNGEDL GLISWFAIHP VSMNNSNHFV NSDNMGYAAY 
LFEQEKNKGY LPGQGPFVAG FASSNLGDVS PNILGPHCVN TGESCDNDKS TCPNGGPSMC 
MASGPGQDMF ESTHIIGRII YQKAKELYAS ASQEVTGPVL AAHQWVNMTD VSVQLNATHT 
VKTCKPALGY SFAAGTIDGV SGLNITQGTT EGDPFWDTLR DQLLGKPSEE IVECQKPKPI 
LLHSGELTIP HPWQPDIVDV QIVTVGSLAI AAIPGELTTM SGRRFREAIK KEFALYGMKD 
MTVVIAGLSN VYTHYITTYE EYQAQRYEAA STIYGPHTLS AYIQLFRDLA KAIATDTVAN 
MSSGPEPPFF KNLIASLIPN IADRAPIGKH FGDVLQPAKP EYRVGEVVEV IFVGANPKNS 
AENQTHQTFL TVEKYEDSVA DWQIMYNDAS WETRFYWHKG ILGLSNATIY WHIPDTAYPG 
IYRIRYFGHN RKQELLKPAV ILAFEGISSP FEVVTT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Asah2

Associated with

Other Information

Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases. PubMed ID: 10753931

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized. PubMed ID: 10652340

Localization of neutral ceramidase in caveolin-enriched light membranes of murine endothelial cells. PubMed ID: 11591392

Neutral ceramidase secreted by endothelial cells is released in part associated with caveolin-1. PubMed ID: 12921776

Neutral ceramidase gene: role in regulating ceramide-induced apoptosis. PubMed ID: 14557071

Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu. PubMed ID: 16126722

Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. PubMed ID: 16380386

Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. PubMed ID: 21613224