Details for: ATR

Gene ID: 545

Symbol: ATR

Ensembl ID: ENSG00000175054

Description: ATR serine/threonine kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.38
    Marker Score: 42179
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.94
    Marker Score: 71532
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.88
    Marker Score: 1096
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.78
    Marker Score: 109251
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.77
    Marker Score: 7321
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.76
    Marker Score: 2368
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.76
    Marker Score: 7161
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.74
    Marker Score: 34645
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.72
    Marker Score: 16305
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.71
    Marker Score: 716
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.7
    Marker Score: 15988
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.68
    Marker Score: 14411
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.65
    Marker Score: 1822.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.65
    Marker Score: 62480
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.63
    Marker Score: 16825
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.62
    Marker Score: 3561
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.61
    Marker Score: 1952
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6
    Marker Score: 1815
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.58
    Marker Score: 12148
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.58
    Marker Score: 6101
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.58
    Marker Score: 1397
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.57
    Marker Score: 23412.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.55
    Marker Score: 454
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.53
    Marker Score: 2369
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.52
    Marker Score: 2927
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.49
    Marker Score: 6256
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.49
    Marker Score: 6885
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.49
    Marker Score: 472
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.48
    Marker Score: 781
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.48
    Marker Score: 1025
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.44
    Marker Score: 1112
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.42
    Marker Score: 1632.5
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.32
    Marker Score: 2220
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.32
    Marker Score: 476
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.3
    Marker Score: 441
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.29
    Marker Score: 352.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.28
    Marker Score: 717
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.27
    Marker Score: 1369
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.27
    Marker Score: 27024.5
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.27
    Marker Score: 462.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.23
    Marker Score: 3497
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.22
    Marker Score: 1521
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.18
    Marker Score: 586
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.17
    Marker Score: 1015
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.17
    Marker Score: 26180
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.17
    Marker Score: 683
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.16
    Marker Score: 7465
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.16
    Marker Score: 333
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.15
    Marker Score: 433
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.13
    Marker Score: 38168
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.09
    Marker Score: 2618
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.07
    Marker Score: 641
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.07
    Marker Score: 2182.5
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.06
    Marker Score: 592.5
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.05
    Marker Score: 4552
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.05
    Marker Score: 337
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.03
    Marker Score: 262.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.03
    Marker Score: 379
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.02
    Marker Score: 3623.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.01
    Marker Score: 491
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1
    Marker Score: 870
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1
    Marker Score: 15608
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71710
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47936
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.99
    Marker Score: 313
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30394
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.98
    Marker Score: 933
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.96
    Marker Score: 5184
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.96
    Marker Score: 4009
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.96
    Marker Score: 359
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.95
    Marker Score: 15314
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.95
    Marker Score: 3277
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.93
    Marker Score: 1319
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.92
    Marker Score: 496
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.91
    Marker Score: 240
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.91
    Marker Score: 3230.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.91
    Marker Score: 1122
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2714
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.9
    Marker Score: 593
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.9
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.87
    Marker Score: 931
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4870
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.84
    Marker Score: 340
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.83
    Marker Score: 1002
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.83
    Marker Score: 622
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.82
    Marker Score: 457
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.81
    Marker Score: 402
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.8
    Marker Score: 546
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.8
    Marker Score: 850
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.8
    Marker Score: 2246
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 320
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.8
    Marker Score: 1292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 605.5
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.79
    Marker Score: 204
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.78
    Marker Score: 641

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Other Information

**Key characteristics:** * Regulates the cell cycle and DNA repair pathways. * Acts as a sensor of replication stress and cellular damage. * Inhibits DNA repair pathways to prevent the accumulation of damaged DNA. * Promotes cell cycle checkpoints to ensure DNA integrity before replication. * Plays a role in the Fanconi anemia pathway, which is responsible for repairing DNA damage caused by exposure to chemicals and radiation. **Pathways and functions:** * ATR is activated by DNA damage and replication stress. * It inhibits the ATM and ATRBP1/ATRBP2 proteins, which are key regulators of the cell cycle. * By blocking ATM and ATRBP1/ATRBP2, ATR promotes the progression of the cell cycle and prevents DNA damage-induced cell death. * ATR also regulates the expression of genes involved in DNA repair and cell cycle checkpoints. * It is involved in the maintenance of genomic integrity and the prevention of cancer. **Clinical significance:** * Mutations in the ATR gene have been linked to several human diseases, including: * Retinoblastoma * Colorectal cancer * Breast cancer * Fanconi anemia * Targeting ATR with small molecule inhibitors is a promising strategy for cancer treatment. * Studies on ATR have also shown potential for the development of novel therapies for neurodegenerative diseases, such as Alzheimer's disease.

Genular Protein ID: 3921141468

Symbol: ATR_HUMAN

Name: Serine/threonine-protein kinase ATR

UniProtKB Accession Codes:

Q13535 Q59HB2 Q7KYL3 Q93051 Q9BXK4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CPTC 1 CTD 1 CarbonylDB 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 5 EMDB 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 40 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 5 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 11 RefSeq 2 Rhea 8 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8978690

Title: The Schizosaccharomyces pombe rad3 checkpoint gene.

PubMed ID: 8978690

DOI: 10.1002/j.1460-2075.1996.tb01054.x

PubMed ID: 8610130

Title: cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.

PubMed ID: 8610130

DOI: 10.1073/pnas.93.7.2850

PubMed ID: 11470508

Title: Evidence for alternate splicing within the mRNA transcript encoding the DNA damage response kinase ATR.

PubMed ID: 11470508

DOI: 10.1016/s0378-1119(01)00543-1

PubMed ID: 8843195

Title: The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.

PubMed ID: 8843195

DOI: 10.1101/gad.10.19.2423

PubMed ID: 9766667

Title: Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

PubMed ID: 9766667

PubMed ID: 9427750

Title: Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.

PubMed ID: 9427750

DOI: 10.1093/emboj/17.1.159

PubMed ID: 9636169

Title: Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control.

PubMed ID: 9636169

DOI: 10.1073/pnas.95.13.7445

PubMed ID: 10545197

Title: Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.

PubMed ID: 10545197

DOI: 10.1021/bi991614n

PubMed ID: 9925639

Title: A role for ATR in the DNA damage-induced phosphorylation of p53.

PubMed ID: 9925639

DOI: 10.1101/gad.13.2.152

PubMed ID: 10608806

Title: Substrate specificities and identification of putative substrates of ATM kinase family members.

PubMed ID: 10608806

DOI: 10.1074/jbc.274.53.37538

PubMed ID: 10597277

Title: ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

PubMed ID: 10597277

DOI: 10.1038/sj.onc.1203077

PubMed ID: 10859164

Title: Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.

PubMed ID: 10859164

PubMed ID: 11114888

Title: Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

PubMed ID: 11114888

DOI: 10.1101/gad.851000

PubMed ID: 11673449

Title: Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.

PubMed ID: 11673449

DOI: 10.1074/jbc.c100569200

PubMed ID: 11418864

Title: ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.

PubMed ID: 11418864

DOI: 10.1038/35082110

PubMed ID: 11721054

Title: ATR and ATRIP: partners in checkpoint signaling.

PubMed ID: 11721054

DOI: 10.1126/science.1065521

PubMed ID: 12526805

Title: ATR regulates fragile site stability.

PubMed ID: 12526805

DOI: 10.1016/s0092-8674(02)01113-3

PubMed ID: 11865061

Title: Hypoxia links ATR and p53 through replication arrest.

PubMed ID: 11865061

DOI: 10.1128/mcb.22.6.1834-1843.2002

PubMed ID: 12011431

Title: Preferential binding of ATR protein to UV-damaged DNA.

PubMed ID: 12011431

DOI: 10.1073/pnas.102167799

PubMed ID: 12814551

Title: ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation.

PubMed ID: 12814551

DOI: 10.1016/s0960-9822(03)00376-2

PubMed ID: 12766152

Title: Human claspin is required for replication checkpoint control.

PubMed ID: 12766152

DOI: 10.1074/jbc.m301136200

PubMed ID: 14657349

Title: MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation.

PubMed ID: 14657349

DOI: 10.1073/pnas.2536810100

PubMed ID: 12791985

Title: Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

PubMed ID: 12791985

DOI: 10.1126/science.1083430

PubMed ID: 15050919

Title: BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint.

PubMed ID: 15050919

DOI: 10.1016/s1535-6108(04)00056-x

PubMed ID: 14742437

Title: UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress.

PubMed ID: 14742437

DOI: 10.1074/jbc.c300554200

PubMed ID: 14871897

Title: Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase.

PubMed ID: 14871897

DOI: 10.1074/jbc.m314212200

PubMed ID: 15314022

Title: ATR couples FANCD2 monoubiquitination to the DNA-damage response.

PubMed ID: 15314022

DOI: 10.1101/gad.1196104

PubMed ID: 15496423

Title: Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway.

PubMed ID: 15496423

DOI: 10.1093/hmg/ddh335

PubMed ID: 14729973

Title: Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities.

PubMed ID: 14729973

DOI: 10.1128/mcb.24.3.1292-1300.2003

PubMed ID: 15210935

Title: Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.

PubMed ID: 15210935

DOI: 10.1073/pnas.0403410101

PubMed ID: 15680327

Title: The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR.

PubMed ID: 15680327

DOI: 10.1016/j.cell.2004.11.054

PubMed ID: 15758953

Title: Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.

PubMed ID: 15758953

DOI: 10.1038/nature03442

PubMed ID: 16530042

Title: TopBP1 activates the ATR-ATRIP complex.

PubMed ID: 16530042

DOI: 10.1016/j.cell.2005.12.041

PubMed ID: 18283122

Title: Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.

PubMed ID: 18283122

DOI: 10.1101/gad.1627708

PubMed ID: 12640452

Title: A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome.

PubMed ID: 12640452

DOI: 10.1038/ng1129

PubMed ID: 16260606

Title: Protein phosphatase 5 is required for ATR-mediated checkpoint activation.

PubMed ID: 16260606

DOI: 10.1128/mcb.25.22.9910-9919.2005

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20810650

Title: A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

PubMed ID: 20810650

DOI: 10.1101/gad.1934210

PubMed ID: 20801936

Title: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.

PubMed ID: 20801936

DOI: 10.1101/gad.1956410

PubMed ID: 20427287

Title: Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

PubMed ID: 20427287

DOI: 10.1074/jbc.m110.121699

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21144835

Title: Protein phosphatase 5 is necessary for ATR-mediated DNA repair.

PubMed ID: 21144835

DOI: 10.1016/j.bbrc.2010.12.005

PubMed ID: 21705319

Title: Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.

PubMed ID: 21705319

DOI: 10.1074/jbc.m111.248914

PubMed ID: 21777809

Title: ATR autophosphorylation as a molecular switch for checkpoint activation.

PubMed ID: 21777809

DOI: 10.1016/j.molcel.2011.06.019

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27723720

Title: ETAA1 acts at stalled replication forks to maintain genome integrity.

PubMed ID: 27723720

DOI: 10.1038/ncb3415

PubMed ID: 27723717

Title: Activation of the ATR kinase by the RPA-binding protein ETAA1.

PubMed ID: 27723717

DOI: 10.1038/ncb3422

PubMed ID: 33848395

Title: UV-induced activation of ATR is mediated by UHRF2.

PubMed ID: 33848395

DOI: 10.1111/gtc.12851

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 22341969

Title: Germline mutation in ATR in autosomal- dominant oropharyngeal cancer syndrome.

PubMed ID: 22341969

DOI: 10.1016/j.ajhg.2012.01.007

Sequence Information:

  • Length: 2644
  • Mass: 301367
  • Checksum: 11BC22297FB9A802
  • Sequence:
    • MGEHGLELAS MIPALRELGS ATPEEYNTVV QKPRQILCQF IDRILTDVNV VAVELVKKTD 
SQPTSVMLLD FIQHIMKSSP LMFVNVSGSH EAKGSCIEFS NWIITRLLRI AATPSCHLLH 
KKICEVICSL LFLFKSKSPA IFGVLTKELL QLFEDLVYLH RRNVMGHAVE WPVVMSRFLS 
QLDEHMGYLQ SAPLQLMSMQ NLEFIEVTLL MVLTRIIAIV FFRRQELLLW QIGCVLLEYG 
SPKIKSLAIS FLTELFQLGG LPAQPASTFF SSFLELLKHL VEMDTDQLKL YEEPLSKLIK 
TLFPFEAEAY RNIEPVYLNM LLEKLCVMFE DGVLMRLKSD LLKAALCHLL QYFLKFVPAG 
YESALQVRKV YVRNICKALL DVLGIEVDAE YLLGPLYAAL KMESMEIIEE IQCQTQQENL 
SSNSDGISPK RRRLSSSLNP SKRAPKQTEE IKHVDMNQKS ILWSALKQKA ESLQISLEYS 
GLKNPVIEML EGIAVVLQLT ALCTVHCSHQ NMNCRTFKDC QHKSKKKPSV VITWMSLDFY 
TKVLKSCRSL LESVQKLDLE ATIDKVVKIY DALIYMQVNS SFEDHILEDL CGMLSLPWIY 
SHSDDGCLKL TTFAANLLTL SCRISDSYSP QAQSRCVFLL TLFPRRIFLE WRTAVYNWAL 
QSSHEVIRAS CVSGFFILLQ QQNSCNRVPK ILIDKVKDDS DIVKKEFASI LGQLVCTLHG 
MFYLTSSLTE PFSEHGHVDL FCRNLKATSQ HECSSSQLKA SVCKPFLFLL KKKIPSPVKL 
AFIDNLHHLC KHLDFREDET DVKAVLGTLL NLMEDPDKDV RVAFSGNIKH ILESLDSEDG 
FIKELFVLRM KEAYTHAQIS RNNELKDTLI LTTGDIGRAA KGDLVPFALL HLLHCLLSKS 
ASVSGAAYTE IRALVAAKSV KLQSFFSQYK KPICQFLVES LHSSQMTALP NTPCQNADVR 
KQDVAHQREM ALNTLSEIAN VFDFPDLNRF LTRTLQVLLP DLAAKASPAA SALIRTLGKQ 
LNVNRREILI NNFKYIFSHL VCSCSKDELE RALHYLKNET EIELGSLLRQ DFQGLHNELL 
LRIGEHYQQV FNGLSILASF ASSDDPYQGP RDIISPELMA DYLQPKLLGI LAFFNMQLLS 
SSVGIEDKKM ALNSLMSLMK LMGPKHVSSV RVKMMTTLRT GLRFKDDFPE LCCRAWDCFV 
RCLDHACLGS LLSHVIVALL PLIHIQPKET AAIFHYLIIE NRDAVQDFLH EIYFLPDHPE 
LKKIKAVLQE YRKETSESTD LQTTLQLSMK AIQHENVDVR IHALTSLKET LYKNQEKLIK 
YATDSETVEP IISQLVTVLL KGCQDANSQA RLLCGECLGE LGAIDPGRLD FSTTETQGKD 
FTFVTGVEDS SFAYGLLMEL TRAYLAYADN SRAQDSAAYA IQELLSIYDC REMETNGPGH 
QLWRRFPEHV REILEPHLNT RYKSSQKSTD WSGVKKPIYL SKLGSNFAEW SASWAGYLIT 
KVRHDLASKI FTCCSIMMKH DFKVTIYLLP HILVYVLLGC NQEDQQEVYA EIMAVLKHDD 
QHTINTQDIA SDLCQLSTQT VFSMLDHLTQ WARHKFQALK AEKCPHSKSN RNKVDSMVST 
VDYEDYQSVT RFLDLIPQDT LAVASFRSKA YTRAVMHFES FITEKKQNIQ EHLGFLQKLY 
AAMHEPDGVA GVSAIRKAEP SLKEQILEHE SLGLLRDATA CYDRAIQLEP DQIIHYHGVV 
KSMLGLGQLS TVITQVNGVH ANRSEWTDEL NTYRVEAAWK LSQWDLVENY LAADGKSTTW 
SVRLGQLLLS AKKRDITAFY DSLKLVRAEQ IVPLSAASFE RGSYQRGYEY IVRLHMLCEL 
EHSIKPLFQH SPGDSSQEDS LNWVARLEMT QNSYRAKEPI LALRRALLSL NKRPDYNEMV 
GECWLQSARV ARKAGHHQTA YNALLNAGES RLAELYVERA KWLWSKGDVH QALIVLQKGV 
ELCFPENETP PEGKNMLIHG RAMLLVGRFM EETANFESNA IMKKYKDVTA CLPEWEDGHF 
YLAKYYDKLM PMVTDNKMEK QGDLIRYIVL HFGRSLQYGN QFIYQSMPRM LTLWLDYGTK 
AYEWEKAGRS DRVQMRNDLG KINKVITEHT NYLAPYQFLT AFSQLISRIC HSHDEVFVVL 
MEIIAKVFLA YPQQAMWMMT AVSKSSYPMR VNRCKEILNK AIHMKKSLEK FVGDATRLTD 
KLLELCNKPV DGSSSTLSMS THFKMLKKLV EEATFSEILI PLQSVMIPTL PSILGTHANH 
ASHEPFPGHW AYIAGFDDMV EILASLQKPK KISLKGSDGK FYIMMCKPKD DLRKDCRLME 
FNSLINKCLR KDAESRRREL HIRTYAVIPL NDECGIIEWV NNTAGLRPIL TKLYKEKGVY 
MTGKELRQCM LPKSAALSEK LKVFREFLLP RHPPIFHEWF LRTFPDPTSW YSSRSAYCRS 
TAVMSMVGYI LGLGDRHGEN ILFDSLTGEC VHVDFNCLFN KGETFEVPEI VPFRLTHNMV 
NGMGPMGTEG LFRRACEVTM RLMRDQREPL MSVLKTFLHD PLVEWSKPVK GHSKAPLNET 
GEVVNEKAKT HVLDIEQRLQ GVIKTRNRVT GLPLSIEGHV HYLIQEATDE NLLCQMYLGW 
TPYM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.