ATR | ENSG00000175054 | NCBI 545

Details for: ATR

Gene ID: 545

Symbol: ATR

Ensembl ID: ENSG00000175054

Description: ATR serine/threonine kinase

Associated with

Activation of atr in response to replication stress
(R-HSA-176187)
Cell cycle
(R-HSA-1640170)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Defective homologous recombination repair (hrr) due to brca2 loss of function
(R-HSA-9701190)
Disease
(R-HSA-1643685)
Diseases of dna double-strand break repair
(R-HSA-9675136)
Diseases of dna repair
(R-HSA-9675135)
Dna double-strand break repair
(R-HSA-5693532)
Fanconi anemia pathway
(R-HSA-6783310)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hdr through homologous recombination (hrr)
(R-HSA-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Hdr through single strand annealing (ssa)
(R-HSA-5685938)
Homologous dna pairing and strand exchange
(R-HSA-5693579)
Homology directed repair
(R-HSA-5693538)
Impaired brca2 binding to rad51
(R-HSA-9709570)
Meiosis
(R-HSA-1500620)
Meiotic synapsis
(R-HSA-1221632)
Presynaptic phase of homologous dna pairing and strand exchange
(R-HSA-5693616)
Processing of dna double-strand break ends
(R-HSA-5693607)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Reproduction
(R-HSA-1474165)
Rna polymerase ii transcription
(R-HSA-73857)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcriptional regulation by tp53
(R-HSA-3700989)
Atp binding
(GO:0005524)
Atr-atrip complex
(GO:0070310)
Cellular response to gamma radiation
(GO:0071480)
Cellular response to uv
(GO:0034644)
Chromatin remodeling
(GO:0006338)
Chromosome
(GO:0005694)
Chromosome, telomeric region
(GO:0000781)
Dna binding
(GO:0003677)
Dna damage checkpoint signaling
(GO:0000077)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Dna replication
(GO:0006260)
Double-strand break repair
(GO:0006302)
Establishment of protein-containing complex localization to telomere
(GO:0097695)
Establishment of rna localization to telomere
(GO:0097694)
Golgi apparatus
(GO:0005794)
Histone h2axs139 kinase activity
(GO:0035979)
Interstrand cross-link repair
(GO:0036297)
Mutlalpha complex binding
(GO:0032405)
Mutsalpha complex binding
(GO:0032407)
Negative regulation of dna replication
(GO:0008156)
Nuclear envelope
(GO:0005635)
Nuclear membrane disassembly
(GO:0051081)
Nucleobase-containing compound metabolic process
(GO:0006139)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Pml body
(GO:0016605)
Positive regulation of dna damage response, signal transduction by p53 class mediator
(GO:0043517)
Positive regulation of telomerase catalytic core complex assembly
(GO:1904884)
Positive regulation of telomere maintenance via telomerase
(GO:0032212)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein localization to chromosome, telomeric region
(GO:0070198)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of cellular response to heat
(GO:1900034)
Regulation of double-strand break repair
(GO:2000779)
Replication fork processing
(GO:0031297)
Replicative senescence
(GO:0090399)
Response to arsenic-containing substance
(GO:0046685)
Response to mechanical stimulus
(GO:0009612)
Response to xenobiotic stimulus
(GO:0009410)
Site of dna damage
(GO:0090734)
Telomere maintenance
(GO:0000723)

Other Information

Proteins

Serine/threonine-protein kinase ATR

Genular Protein ID: 3921141468

Symbol: ATR_HUMAN

Name: Serine/threonine-protein kinase ATR

UniProtKB Accession Codes:

Q13535 Q59HB2 Q7KYL3 Q93051 Q9BXK4

Database IDs:

Citations:

PubMed ID: 8978690

Title: The Schizosaccharomyces pombe rad3 checkpoint gene.

PubMed ID: 8978690

DOI: 10.1002/j.1460-2075.1996.tb01054.x

PubMed ID: 8610130

Title: cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.

PubMed ID: 8610130

DOI: 10.1073/pnas.93.7.2850

PubMed ID: 11470508

Title: Evidence for alternate splicing within the mRNA transcript encoding the DNA damage response kinase ATR.

PubMed ID: 11470508

DOI: 10.1016/s0378-1119(01)00543-1

PubMed ID: 8843195

Title: The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.

PubMed ID: 8843195

DOI: 10.1101/gad.10.19.2423

PubMed ID: 9766667

Title: Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

PubMed ID: 9766667

PubMed ID: 9427750

Title: Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.

PubMed ID: 9427750

DOI: 10.1093/emboj/17.1.159

PubMed ID: 9636169

Title: Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control.

PubMed ID: 9636169

DOI: 10.1073/pnas.95.13.7445

PubMed ID: 10545197

Title: Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.

PubMed ID: 10545197

DOI: 10.1021/bi991614n

PubMed ID: 9925639

Title: A role for ATR in the DNA damage-induced phosphorylation of p53.

PubMed ID: 9925639

DOI: 10.1101/gad.13.2.152

PubMed ID: 10608806

Title: Substrate specificities and identification of putative substrates of ATM kinase family members.

PubMed ID: 10608806

DOI: 10.1074/jbc.274.53.37538

PubMed ID: 10597277

Title: ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

PubMed ID: 10597277

DOI: 10.1038/sj.onc.1203077

PubMed ID: 10859164

Title: Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.

PubMed ID: 10859164

PubMed ID: 11114888

Title: Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

PubMed ID: 11114888

DOI: 10.1101/gad.851000

PubMed ID: 11673449

Title: Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.

PubMed ID: 11673449

DOI: 10.1074/jbc.c100569200

PubMed ID: 11418864

Title: ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.

PubMed ID: 11418864

DOI: 10.1038/35082110

PubMed ID: 11721054

Title: ATR and ATRIP: partners in checkpoint signaling.

PubMed ID: 11721054

DOI: 10.1126/science.1065521

PubMed ID: 12526805

Title: ATR regulates fragile site stability.

PubMed ID: 12526805

DOI: 10.1016/s0092-8674(02)01113-3

PubMed ID: 11865061

Title: Hypoxia links ATR and p53 through replication arrest.

PubMed ID: 11865061

DOI: 10.1128/mcb.22.6.1834-1843.2002

PubMed ID: 12011431

Title: Preferential binding of ATR protein to UV-damaged DNA.

PubMed ID: 12011431

DOI: 10.1073/pnas.102167799

PubMed ID: 12814551

Title: ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation.

PubMed ID: 12814551

DOI: 10.1016/s0960-9822(03)00376-2

PubMed ID: 12766152

Title: Human claspin is required for replication checkpoint control.

PubMed ID: 12766152

DOI: 10.1074/jbc.m301136200

PubMed ID: 14657349

Title: MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation.

PubMed ID: 14657349

DOI: 10.1073/pnas.2536810100

PubMed ID: 12791985

Title: Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

PubMed ID: 12791985

DOI: 10.1126/science.1083430

PubMed ID: 15050919

Title: BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint.

PubMed ID: 15050919

DOI: 10.1016/s1535-6108(04)00056-x

PubMed ID: 14742437

Title: UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress.

PubMed ID: 14742437

DOI: 10.1074/jbc.c300554200

PubMed ID: 14871897

Title: Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase.

PubMed ID: 14871897

DOI: 10.1074/jbc.m314212200

PubMed ID: 15314022

Title: ATR couples FANCD2 monoubiquitination to the DNA-damage response.

PubMed ID: 15314022

DOI: 10.1101/gad.1196104

PubMed ID: 15496423

Title: Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway.

PubMed ID: 15496423

DOI: 10.1093/hmg/ddh335

PubMed ID: 14729973

Title: Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities.

PubMed ID: 14729973

DOI: 10.1128/mcb.24.3.1292-1300.2003

PubMed ID: 15210935

Title: Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.

PubMed ID: 15210935

DOI: 10.1073/pnas.0403410101

PubMed ID: 15680327

Title: The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR.

PubMed ID: 15680327

DOI: 10.1016/j.cell.2004.11.054

PubMed ID: 15758953

Title: Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.

PubMed ID: 15758953

DOI: 10.1038/nature03442

PubMed ID: 16530042

Title: TopBP1 activates the ATR-ATRIP complex.

PubMed ID: 16530042

DOI: 10.1016/j.cell.2005.12.041

PubMed ID: 18283122

Title: Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.

PubMed ID: 18283122

DOI: 10.1101/gad.1627708

PubMed ID: 12640452

Title: A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome.

PubMed ID: 12640452

DOI: 10.1038/ng1129

PubMed ID: 16260606

Title: Protein phosphatase 5 is required for ATR-mediated checkpoint activation.

PubMed ID: 16260606

DOI: 10.1128/mcb.25.22.9910-9919.2005

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20810650

Title: A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

PubMed ID: 20810650

DOI: 10.1101/gad.1934210

PubMed ID: 20801936

Title: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.

PubMed ID: 20801936

DOI: 10.1101/gad.1956410

PubMed ID: 20427287

Title: Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

PubMed ID: 20427287

DOI: 10.1074/jbc.m110.121699

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21144835

Title: Protein phosphatase 5 is necessary for ATR-mediated DNA repair.

PubMed ID: 21144835

DOI: 10.1016/j.bbrc.2010.12.005

PubMed ID: 21705319

Title: Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.

PubMed ID: 21705319

DOI: 10.1074/jbc.m111.248914

PubMed ID: 21777809

Title: ATR autophosphorylation as a molecular switch for checkpoint activation.

PubMed ID: 21777809

DOI: 10.1016/j.molcel.2011.06.019

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27723720

Title: ETAA1 acts at stalled replication forks to maintain genome integrity.

PubMed ID: 27723720

DOI: 10.1038/ncb3415

PubMed ID: 27723717

Title: Activation of the ATR kinase by the RPA-binding protein ETAA1.

PubMed ID: 27723717

DOI: 10.1038/ncb3422

PubMed ID: 33848395

Title: UV-induced activation of ATR is mediated by UHRF2.

PubMed ID: 33848395

DOI: 10.1111/gtc.12851

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 22341969

Title: Germline mutation in ATR in autosomal- dominant oropharyngeal cancer syndrome.

PubMed ID: 22341969

DOI: 10.1016/j.ajhg.2012.01.007

Sequence Information:

Length: 2644
Mass: 301367
Checksum: 11BC22297FB9A802
Sequence:

MGEHGLELAS MIPALRELGS ATPEEYNTVV QKPRQILCQF IDRILTDVNV VAVELVKKTD 
SQPTSVMLLD FIQHIMKSSP LMFVNVSGSH EAKGSCIEFS NWIITRLLRI AATPSCHLLH 
KKICEVICSL LFLFKSKSPA IFGVLTKELL QLFEDLVYLH RRNVMGHAVE WPVVMSRFLS 
QLDEHMGYLQ SAPLQLMSMQ NLEFIEVTLL MVLTRIIAIV FFRRQELLLW QIGCVLLEYG 
SPKIKSLAIS FLTELFQLGG LPAQPASTFF SSFLELLKHL VEMDTDQLKL YEEPLSKLIK 
TLFPFEAEAY RNIEPVYLNM LLEKLCVMFE DGVLMRLKSD LLKAALCHLL QYFLKFVPAG 
YESALQVRKV YVRNICKALL DVLGIEVDAE YLLGPLYAAL KMESMEIIEE IQCQTQQENL 
SSNSDGISPK RRRLSSSLNP SKRAPKQTEE IKHVDMNQKS ILWSALKQKA ESLQISLEYS 
GLKNPVIEML EGIAVVLQLT ALCTVHCSHQ NMNCRTFKDC QHKSKKKPSV VITWMSLDFY 
TKVLKSCRSL LESVQKLDLE ATIDKVVKIY DALIYMQVNS SFEDHILEDL CGMLSLPWIY 
SHSDDGCLKL TTFAANLLTL SCRISDSYSP QAQSRCVFLL TLFPRRIFLE WRTAVYNWAL 
QSSHEVIRAS CVSGFFILLQ QQNSCNRVPK ILIDKVKDDS DIVKKEFASI LGQLVCTLHG 
MFYLTSSLTE PFSEHGHVDL FCRNLKATSQ HECSSSQLKA SVCKPFLFLL KKKIPSPVKL 
AFIDNLHHLC KHLDFREDET DVKAVLGTLL NLMEDPDKDV RVAFSGNIKH ILESLDSEDG 
FIKELFVLRM KEAYTHAQIS RNNELKDTLI LTTGDIGRAA KGDLVPFALL HLLHCLLSKS 
ASVSGAAYTE IRALVAAKSV KLQSFFSQYK KPICQFLVES LHSSQMTALP NTPCQNADVR 
KQDVAHQREM ALNTLSEIAN VFDFPDLNRF LTRTLQVLLP DLAAKASPAA SALIRTLGKQ 
LNVNRREILI NNFKYIFSHL VCSCSKDELE RALHYLKNET EIELGSLLRQ DFQGLHNELL 
LRIGEHYQQV FNGLSILASF ASSDDPYQGP RDIISPELMA DYLQPKLLGI LAFFNMQLLS 
SSVGIEDKKM ALNSLMSLMK LMGPKHVSSV RVKMMTTLRT GLRFKDDFPE LCCRAWDCFV 
RCLDHACLGS LLSHVIVALL PLIHIQPKET AAIFHYLIIE NRDAVQDFLH EIYFLPDHPE 
LKKIKAVLQE YRKETSESTD LQTTLQLSMK AIQHENVDVR IHALTSLKET LYKNQEKLIK 
YATDSETVEP IISQLVTVLL KGCQDANSQA RLLCGECLGE LGAIDPGRLD FSTTETQGKD 
FTFVTGVEDS SFAYGLLMEL TRAYLAYADN SRAQDSAAYA IQELLSIYDC REMETNGPGH 
QLWRRFPEHV REILEPHLNT RYKSSQKSTD WSGVKKPIYL SKLGSNFAEW SASWAGYLIT 
KVRHDLASKI FTCCSIMMKH DFKVTIYLLP HILVYVLLGC NQEDQQEVYA EIMAVLKHDD 
QHTINTQDIA SDLCQLSTQT VFSMLDHLTQ WARHKFQALK AEKCPHSKSN RNKVDSMVST 
VDYEDYQSVT RFLDLIPQDT LAVASFRSKA YTRAVMHFES FITEKKQNIQ EHLGFLQKLY 
AAMHEPDGVA GVSAIRKAEP SLKEQILEHE SLGLLRDATA CYDRAIQLEP DQIIHYHGVV 
KSMLGLGQLS TVITQVNGVH ANRSEWTDEL NTYRVEAAWK LSQWDLVENY LAADGKSTTW 
SVRLGQLLLS AKKRDITAFY DSLKLVRAEQ IVPLSAASFE RGSYQRGYEY IVRLHMLCEL 
EHSIKPLFQH SPGDSSQEDS LNWVARLEMT QNSYRAKEPI LALRRALLSL NKRPDYNEMV 
GECWLQSARV ARKAGHHQTA YNALLNAGES RLAELYVERA KWLWSKGDVH QALIVLQKGV 
ELCFPENETP PEGKNMLIHG RAMLLVGRFM EETANFESNA IMKKYKDVTA CLPEWEDGHF 
YLAKYYDKLM PMVTDNKMEK QGDLIRYIVL HFGRSLQYGN QFIYQSMPRM LTLWLDYGTK 
AYEWEKAGRS DRVQMRNDLG KINKVITEHT NYLAPYQFLT AFSQLISRIC HSHDEVFVVL 
MEIIAKVFLA YPQQAMWMMT AVSKSSYPMR VNRCKEILNK AIHMKKSLEK FVGDATRLTD 
KLLELCNKPV DGSSSTLSMS THFKMLKKLV EEATFSEILI PLQSVMIPTL PSILGTHANH 
ASHEPFPGHW AYIAGFDDMV EILASLQKPK KISLKGSDGK FYIMMCKPKD DLRKDCRLME 
FNSLINKCLR KDAESRRREL HIRTYAVIPL NDECGIIEWV NNTAGLRPIL TKLYKEKGVY 
MTGKELRQCM LPKSAALSEK LKVFREFLLP RHPPIFHEWF LRTFPDPTSW YSSRSAYCRS 
TAVMSMVGYI LGLGDRHGEN ILFDSLTGEC VHVDFNCLFN KGETFEVPEI VPFRLTHNMV 
NGMGPMGTEG LFRRACEVTM RLMRDQREPL MSVLKTFLHD PLVEWSKPVK GHSKAPLNET 
GEVVNEKAKT HVLDIEQRLQ GVIKTRNRVT GLPLSIEGHV HYLIQEATDE NLLCQMYLGW 
TPYM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ATR

Associated with

Other Information

The Schizosaccharomyces pombe rad3 checkpoint gene. PubMed ID: 8978690

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. PubMed ID: 8610130

Evidence for alternate splicing within the mRNA transcript encoding the DNA damage response kinase ATR. PubMed ID: 11470508

The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. PubMed ID: 8843195

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. PubMed ID: 9766667

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. PubMed ID: 9427750

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control. PubMed ID: 9636169

Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. PubMed ID: 10545197

A role for ATR in the DNA damage-induced phosphorylation of p53. PubMed ID: 9925639

Substrate specificities and identification of putative substrates of ATM kinase family members. PubMed ID: 10608806

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK. PubMed ID: 10597277

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. PubMed ID: 10859164

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. PubMed ID: 11114888

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. PubMed ID: 11673449

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. PubMed ID: 11418864

ATR and ATRIP: partners in checkpoint signaling. PubMed ID: 11721054

ATR regulates fragile site stability. PubMed ID: 12526805

Hypoxia links ATR and p53 through replication arrest. PubMed ID: 11865061

Preferential binding of ATR protein to UV-damaged DNA. PubMed ID: 12011431

ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation. PubMed ID: 12814551

Human claspin is required for replication checkpoint control. PubMed ID: 12766152

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. PubMed ID: 14657349

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. PubMed ID: 12791985

BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint. PubMed ID: 15050919

UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress. PubMed ID: 14742437

Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase. PubMed ID: 14871897

ATR couples FANCD2 monoubiquitination to the DNA-damage response. PubMed ID: 15314022

Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway. PubMed ID: 15496423

Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities. PubMed ID: 14729973

Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. PubMed ID: 15210935

The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR. PubMed ID: 15680327

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. PubMed ID: 15758953

TopBP1 activates the ATR-ATRIP complex. PubMed ID: 16530042

Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. PubMed ID: 18283122

A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. PubMed ID: 12640452

Protein phosphatase 5 is required for ATR-mediated checkpoint activation. PubMed ID: 16260606

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. PubMed ID: 20810650

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. PubMed ID: 20801936

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. PubMed ID: 20427287

Initial characterization of the human central proteome. PubMed ID: 21269460

Protein phosphatase 5 is necessary for ATR-mediated DNA repair. PubMed ID: 21144835

Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase. PubMed ID: 21705319

ATR autophosphorylation as a molecular switch for checkpoint activation. PubMed ID: 21777809

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

ETAA1 acts at stalled replication forks to maintain genome integrity. PubMed ID: 27723720

Activation of the ATR kinase by the RPA-binding protein ETAA1. PubMed ID: 27723717

UV-induced activation of ATR is mediated by UHRF2. PubMed ID: 33848395

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

Germline mutation in ATR in autosomal- dominant oropharyngeal cancer syndrome. PubMed ID: 22341969