Details for: ATR

Gene ID: 545

Symbol: ATR

Ensembl ID: ENSG00000175054

Description: ATR serine/threonine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 233.6298
    Cell Significance Index: -36.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 140.5911
    Cell Significance Index: -35.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 80.0216
    Cell Significance Index: -37.7800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 74.5341
    Cell Significance Index: -30.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.4506
    Cell Significance Index: -35.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.8201
    Cell Significance Index: -30.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.8226
    Cell Significance Index: -36.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.3826
    Cell Significance Index: -35.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.9846
    Cell Significance Index: -36.8100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.7245
    Cell Significance Index: -25.6600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.3587
    Cell Significance Index: -36.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.6447
    Cell Significance Index: 70.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.6029
    Cell Significance Index: 378.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1404
    Cell Significance Index: 429.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.7379
    Cell Significance Index: 76.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.6947
    Cell Significance Index: 64.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6325
    Cell Significance Index: 91.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6206
    Cell Significance Index: 45.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6203
    Cell Significance Index: 321.5600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.2752
    Cell Significance Index: 11.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2305
    Cell Significance Index: 94.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1909
    Cell Significance Index: 427.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1580
    Cell Significance Index: 22.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0597
    Cell Significance Index: 26.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.0246
    Cell Significance Index: 29.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0018
    Cell Significance Index: 67.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7811
    Cell Significance Index: 705.3200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.7127
    Cell Significance Index: 10.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6281
    Cell Significance Index: 102.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6246
    Cell Significance Index: 67.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6171
    Cell Significance Index: 426.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6141
    Cell Significance Index: 36.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6070
    Cell Significance Index: 109.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5590
    Cell Significance Index: 68.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4233
    Cell Significance Index: 12.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3614
    Cell Significance Index: 35.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2764
    Cell Significance Index: 12.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2418
    Cell Significance Index: 14.8600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2078
    Cell Significance Index: 3.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1819
    Cell Significance Index: 115.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1782
    Cell Significance Index: 335.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1588
    Cell Significance Index: 3.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1557
    Cell Significance Index: 287.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1553
    Cell Significance Index: 3.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1550
    Cell Significance Index: 84.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1458
    Cell Significance Index: 224.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1430
    Cell Significance Index: 19.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1291
    Cell Significance Index: 58.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1193
    Cell Significance Index: 13.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1152
    Cell Significance Index: 5.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0998
    Cell Significance Index: 44.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0883
    Cell Significance Index: 16.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0864
    Cell Significance Index: 1.4800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0675
    Cell Significance Index: 0.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0561
    Cell Significance Index: 6.6200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0542
    Cell Significance Index: 0.7800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0463
    Cell Significance Index: 0.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0398
    Cell Significance Index: 54.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0225
    Cell Significance Index: 1.0500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0159
    Cell Significance Index: 0.2000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0130
    Cell Significance Index: -0.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0315
    Cell Significance Index: -0.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0330
    Cell Significance Index: -24.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0343
    Cell Significance Index: -1.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0416
    Cell Significance Index: -30.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0477
    Cell Significance Index: -36.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0513
    Cell Significance Index: -2.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0536
    Cell Significance Index: -3.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0552
    Cell Significance Index: -9.4200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0629
    Cell Significance Index: -0.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0632
    Cell Significance Index: -35.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0654
    Cell Significance Index: -40.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0837
    Cell Significance Index: -2.9400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1088
    Cell Significance Index: -2.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1116
    Cell Significance Index: -32.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1405
    Cell Significance Index: -9.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1622
    Cell Significance Index: -16.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1771
    Cell Significance Index: -22.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1778
    Cell Significance Index: -20.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1815
    Cell Significance Index: -38.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1959
    Cell Significance Index: -4.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1980
    Cell Significance Index: -2.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2169
    Cell Significance Index: -4.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2220
    Cell Significance Index: -23.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2314
    Cell Significance Index: -29.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2350
    Cell Significance Index: -5.0100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2588
    Cell Significance Index: -3.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3021
    Cell Significance Index: -4.4600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.3321
    Cell Significance Index: -3.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3357
    Cell Significance Index: -23.7400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3673
    Cell Significance Index: -4.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3956
    Cell Significance Index: -10.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3965
    Cell Significance Index: -29.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4080
    Cell Significance Index: -32.3100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4734
    Cell Significance Index: -2.8600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.5127
    Cell Significance Index: -7.8000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5234
    Cell Significance Index: -4.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5272
    Cell Significance Index: -11.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5453
    Cell Significance Index: -28.6300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5467
    Cell Significance Index: -6.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Serine/threonine kinase activity**: ATR has kinase activity, which allows it to phosphorylate and regulate downstream targets. 2. **DNA damage response**: ATR is activated in response to DNA damage and integrates signals from various pathways to regulate cellular responses. 3. **Cell cycle checkpoint**: ATR regulates the cell cycle checkpoint, preventing cells from entering S phase until DNA damage is repaired. 4. **DNA repair**: ATR regulates DNA repair pathways, including homologous recombination repair (HRR) and non-homologous end joining (NHEJ). 5. **Stress response**: ATR is activated in response to various forms of cellular stress, including heat shock, UV radiation, and oxidative stress. **Pathways and Functions** 1. **Activation of ATR in response to replication stress**: ATR is activated in response to replication stress, which is a major cause of DNA damage. 2. **Atp binding**: ATR binds to ATP, which is necessary for its kinase activity. 3. **ATR-ATRIP complex**: ATR forms a complex with ATRIP, which is necessary for its function. 4. **Cell cycle checkpoint**: ATR regulates the cell cycle checkpoint, preventing cells from entering S phase until DNA damage is repaired. 5. **DNA damage response**: ATR integrates signals from various pathways to regulate cellular responses to DNA damage. 6. **Homologous recombination repair**: ATR regulates HRR, which is a major pathway for repairing DNA double-strand breaks. 7. **Non-homologous end joining**: ATR regulates NHEJ, which is another pathway for repairing DNA double-strand breaks. **Clinical Significance** 1. **Ataxia-Telangiectasia**: Mutations in the ATR gene are associated with ataxia-telangiectasia, a genetic disorder characterized by impaired DNA repair and increased susceptibility to cancer. 2. **Cancer**: ATR is overexpressed in many types of cancer, including breast, lung, and colon cancer. 3. **Neurodegenerative diseases**: ATR is implicated in neurodegenerative diseases, including Alzheimer's and Parkinson's disease. 4. **Radiosensitivity**: ATR is a target for radiation therapy, as mutations in the ATR gene can increase radiosensitivity. 5. **Telomere maintenance**: ATR regulates telomere maintenance, which is critical for preventing cancer and promoting healthy aging. In conclusion, the ATR gene is a critical regulator of genomic stability and DNA damage response. Its dysregulation is associated with various diseases, including ataxia-telangiectasia, cancer, and neurodegenerative diseases. Understanding the function of ATR is essential for developing new therapies for these diseases.

Genular Protein ID: 3921141468

Symbol: ATR_HUMAN

Name: Serine/threonine-protein kinase ATR

UniProtKB Accession Codes:

Q13535 Q59HB2 Q7KYL3 Q93051 Q9BXK4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CPTC 1 CTD 1 CarbonylDB 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 5 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 44 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 11 RefSeq 2 Rhea 8 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8978690

Title: The Schizosaccharomyces pombe rad3 checkpoint gene.

PubMed ID: 8978690

DOI: 10.1002/j.1460-2075.1996.tb01054.x

PubMed ID: 8610130

Title: cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.

PubMed ID: 8610130

DOI: 10.1073/pnas.93.7.2850

PubMed ID: 11470508

Title: Evidence for alternate splicing within the mRNA transcript encoding the DNA damage response kinase ATR.

PubMed ID: 11470508

DOI: 10.1016/s0378-1119(01)00543-1

PubMed ID: 8843195

Title: The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.

PubMed ID: 8843195

DOI: 10.1101/gad.10.19.2423

PubMed ID: 9766667

Title: Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

PubMed ID: 9766667

PubMed ID: 9427750

Title: Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.

PubMed ID: 9427750

DOI: 10.1093/emboj/17.1.159

PubMed ID: 9636169

Title: Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control.

PubMed ID: 9636169

DOI: 10.1073/pnas.95.13.7445

PubMed ID: 10545197

Title: Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.

PubMed ID: 10545197

DOI: 10.1021/bi991614n

PubMed ID: 9925639

Title: A role for ATR in the DNA damage-induced phosphorylation of p53.

PubMed ID: 9925639

DOI: 10.1101/gad.13.2.152

PubMed ID: 10608806

Title: Substrate specificities and identification of putative substrates of ATM kinase family members.

PubMed ID: 10608806

DOI: 10.1074/jbc.274.53.37538

PubMed ID: 10597277

Title: ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

PubMed ID: 10597277

DOI: 10.1038/sj.onc.1203077

PubMed ID: 10859164

Title: Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.

PubMed ID: 10859164

PubMed ID: 11114888

Title: Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

PubMed ID: 11114888

DOI: 10.1101/gad.851000

PubMed ID: 11673449

Title: Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.

PubMed ID: 11673449

DOI: 10.1074/jbc.c100569200

PubMed ID: 11418864

Title: ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.

PubMed ID: 11418864

DOI: 10.1038/35082110

PubMed ID: 11721054

Title: ATR and ATRIP: partners in checkpoint signaling.

PubMed ID: 11721054

DOI: 10.1126/science.1065521

PubMed ID: 12526805

Title: ATR regulates fragile site stability.

PubMed ID: 12526805

DOI: 10.1016/s0092-8674(02)01113-3

PubMed ID: 11865061

Title: Hypoxia links ATR and p53 through replication arrest.

PubMed ID: 11865061

DOI: 10.1128/mcb.22.6.1834-1843.2002

PubMed ID: 12011431

Title: Preferential binding of ATR protein to UV-damaged DNA.

PubMed ID: 12011431

DOI: 10.1073/pnas.102167799

PubMed ID: 12814551

Title: ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation.

PubMed ID: 12814551

DOI: 10.1016/s0960-9822(03)00376-2

PubMed ID: 12766152

Title: Human claspin is required for replication checkpoint control.

PubMed ID: 12766152

DOI: 10.1074/jbc.m301136200

PubMed ID: 14657349

Title: MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation.

PubMed ID: 14657349

DOI: 10.1073/pnas.2536810100

PubMed ID: 12791985

Title: Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

PubMed ID: 12791985

DOI: 10.1126/science.1083430

PubMed ID: 15050919

Title: BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint.

PubMed ID: 15050919

DOI: 10.1016/s1535-6108(04)00056-x

PubMed ID: 14742437

Title: UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress.

PubMed ID: 14742437

DOI: 10.1074/jbc.c300554200

PubMed ID: 14871897

Title: Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase.

PubMed ID: 14871897

DOI: 10.1074/jbc.m314212200

PubMed ID: 15314022

Title: ATR couples FANCD2 monoubiquitination to the DNA-damage response.

PubMed ID: 15314022

DOI: 10.1101/gad.1196104

PubMed ID: 15496423

Title: Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway.

PubMed ID: 15496423

DOI: 10.1093/hmg/ddh335

PubMed ID: 14729973

Title: Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities.

PubMed ID: 14729973

DOI: 10.1128/mcb.24.3.1292-1300.2003

PubMed ID: 15210935

Title: Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.

PubMed ID: 15210935

DOI: 10.1073/pnas.0403410101

PubMed ID: 15680327

Title: The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR.

PubMed ID: 15680327

DOI: 10.1016/j.cell.2004.11.054

PubMed ID: 15758953

Title: Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.

PubMed ID: 15758953

DOI: 10.1038/nature03442

PubMed ID: 16530042

Title: TopBP1 activates the ATR-ATRIP complex.

PubMed ID: 16530042

DOI: 10.1016/j.cell.2005.12.041

PubMed ID: 18283122

Title: Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.

PubMed ID: 18283122

DOI: 10.1101/gad.1627708

PubMed ID: 12640452

Title: A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome.

PubMed ID: 12640452

DOI: 10.1038/ng1129

PubMed ID: 16260606

Title: Protein phosphatase 5 is required for ATR-mediated checkpoint activation.

PubMed ID: 16260606

DOI: 10.1128/mcb.25.22.9910-9919.2005

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20810650

Title: A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

PubMed ID: 20810650

DOI: 10.1101/gad.1934210

PubMed ID: 20801936

Title: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.

PubMed ID: 20801936

DOI: 10.1101/gad.1956410

PubMed ID: 20427287

Title: Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

PubMed ID: 20427287

DOI: 10.1074/jbc.m110.121699

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21144835

Title: Protein phosphatase 5 is necessary for ATR-mediated DNA repair.

PubMed ID: 21144835

DOI: 10.1016/j.bbrc.2010.12.005

PubMed ID: 21705319

Title: Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.

PubMed ID: 21705319

DOI: 10.1074/jbc.m111.248914

PubMed ID: 21777809

Title: ATR autophosphorylation as a molecular switch for checkpoint activation.

PubMed ID: 21777809

DOI: 10.1016/j.molcel.2011.06.019

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23273981

Title: Activation of DSB processing requires phosphorylation of CtIP by ATR.

PubMed ID: 23273981

DOI: 10.1016/j.molcel.2012.11.020

PubMed ID: 25083873

Title: ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress.

PubMed ID: 25083873

DOI: 10.1016/j.cell.2014.05.046

PubMed ID: 27723720

Title: ETAA1 acts at stalled replication forks to maintain genome integrity.

PubMed ID: 27723720

DOI: 10.1038/ncb3415

PubMed ID: 27723717

Title: Activation of the ATR kinase by the RPA-binding protein ETAA1.

PubMed ID: 27723717

DOI: 10.1038/ncb3422

PubMed ID: 30139873

Title: An intrinsic S/G2 checkpoint enforced by ATR.

PubMed ID: 30139873

DOI: 10.1126/science.aap9346

PubMed ID: 33848395

Title: UV-induced activation of ATR is mediated by UHRF2.

PubMed ID: 33848395

DOI: 10.1111/gtc.12851

PubMed ID: 37788673

Title: ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei.

PubMed ID: 37788673

DOI: 10.1016/j.molcel.2023.09.003

PubMed ID: 37832547

Title: DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C.

PubMed ID: 37832547

DOI: 10.1016/j.molcel.2023.09.023

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 22341969

Title: Germline mutation in ATR in autosomal- dominant oropharyngeal cancer syndrome.

PubMed ID: 22341969

DOI: 10.1016/j.ajhg.2012.01.007

Sequence Information:

  • Length: 2644
  • Mass: 301367
  • Checksum: 11BC22297FB9A802
  • Sequence:
    • MGEHGLELAS MIPALRELGS ATPEEYNTVV QKPRQILCQF IDRILTDVNV VAVELVKKTD 
SQPTSVMLLD FIQHIMKSSP LMFVNVSGSH EAKGSCIEFS NWIITRLLRI AATPSCHLLH 
KKICEVICSL LFLFKSKSPA IFGVLTKELL QLFEDLVYLH RRNVMGHAVE WPVVMSRFLS 
QLDEHMGYLQ SAPLQLMSMQ NLEFIEVTLL MVLTRIIAIV FFRRQELLLW QIGCVLLEYG 
SPKIKSLAIS FLTELFQLGG LPAQPASTFF SSFLELLKHL VEMDTDQLKL YEEPLSKLIK 
TLFPFEAEAY RNIEPVYLNM LLEKLCVMFE DGVLMRLKSD LLKAALCHLL QYFLKFVPAG 
YESALQVRKV YVRNICKALL DVLGIEVDAE YLLGPLYAAL KMESMEIIEE IQCQTQQENL 
SSNSDGISPK RRRLSSSLNP SKRAPKQTEE IKHVDMNQKS ILWSALKQKA ESLQISLEYS 
GLKNPVIEML EGIAVVLQLT ALCTVHCSHQ NMNCRTFKDC QHKSKKKPSV VITWMSLDFY 
TKVLKSCRSL LESVQKLDLE ATIDKVVKIY DALIYMQVNS SFEDHILEDL CGMLSLPWIY 
SHSDDGCLKL TTFAANLLTL SCRISDSYSP QAQSRCVFLL TLFPRRIFLE WRTAVYNWAL 
QSSHEVIRAS CVSGFFILLQ QQNSCNRVPK ILIDKVKDDS DIVKKEFASI LGQLVCTLHG 
MFYLTSSLTE PFSEHGHVDL FCRNLKATSQ HECSSSQLKA SVCKPFLFLL KKKIPSPVKL 
AFIDNLHHLC KHLDFREDET DVKAVLGTLL NLMEDPDKDV RVAFSGNIKH ILESLDSEDG 
FIKELFVLRM KEAYTHAQIS RNNELKDTLI LTTGDIGRAA KGDLVPFALL HLLHCLLSKS 
ASVSGAAYTE IRALVAAKSV KLQSFFSQYK KPICQFLVES LHSSQMTALP NTPCQNADVR 
KQDVAHQREM ALNTLSEIAN VFDFPDLNRF LTRTLQVLLP DLAAKASPAA SALIRTLGKQ 
LNVNRREILI NNFKYIFSHL VCSCSKDELE RALHYLKNET EIELGSLLRQ DFQGLHNELL 
LRIGEHYQQV FNGLSILASF ASSDDPYQGP RDIISPELMA DYLQPKLLGI LAFFNMQLLS 
SSVGIEDKKM ALNSLMSLMK LMGPKHVSSV RVKMMTTLRT GLRFKDDFPE LCCRAWDCFV 
RCLDHACLGS LLSHVIVALL PLIHIQPKET AAIFHYLIIE NRDAVQDFLH EIYFLPDHPE 
LKKIKAVLQE YRKETSESTD LQTTLQLSMK AIQHENVDVR IHALTSLKET LYKNQEKLIK 
YATDSETVEP IISQLVTVLL KGCQDANSQA RLLCGECLGE LGAIDPGRLD FSTTETQGKD 
FTFVTGVEDS SFAYGLLMEL TRAYLAYADN SRAQDSAAYA IQELLSIYDC REMETNGPGH 
QLWRRFPEHV REILEPHLNT RYKSSQKSTD WSGVKKPIYL SKLGSNFAEW SASWAGYLIT 
KVRHDLASKI FTCCSIMMKH DFKVTIYLLP HILVYVLLGC NQEDQQEVYA EIMAVLKHDD 
QHTINTQDIA SDLCQLSTQT VFSMLDHLTQ WARHKFQALK AEKCPHSKSN RNKVDSMVST 
VDYEDYQSVT RFLDLIPQDT LAVASFRSKA YTRAVMHFES FITEKKQNIQ EHLGFLQKLY 
AAMHEPDGVA GVSAIRKAEP SLKEQILEHE SLGLLRDATA CYDRAIQLEP DQIIHYHGVV 
KSMLGLGQLS TVITQVNGVH ANRSEWTDEL NTYRVEAAWK LSQWDLVENY LAADGKSTTW 
SVRLGQLLLS AKKRDITAFY DSLKLVRAEQ IVPLSAASFE RGSYQRGYEY IVRLHMLCEL 
EHSIKPLFQH SPGDSSQEDS LNWVARLEMT QNSYRAKEPI LALRRALLSL NKRPDYNEMV 
GECWLQSARV ARKAGHHQTA YNALLNAGES RLAELYVERA KWLWSKGDVH QALIVLQKGV 
ELCFPENETP PEGKNMLIHG RAMLLVGRFM EETANFESNA IMKKYKDVTA CLPEWEDGHF 
YLAKYYDKLM PMVTDNKMEK QGDLIRYIVL HFGRSLQYGN QFIYQSMPRM LTLWLDYGTK 
AYEWEKAGRS DRVQMRNDLG KINKVITEHT NYLAPYQFLT AFSQLISRIC HSHDEVFVVL 
MEIIAKVFLA YPQQAMWMMT AVSKSSYPMR VNRCKEILNK AIHMKKSLEK FVGDATRLTD 
KLLELCNKPV DGSSSTLSMS THFKMLKKLV EEATFSEILI PLQSVMIPTL PSILGTHANH 
ASHEPFPGHW AYIAGFDDMV EILASLQKPK KISLKGSDGK FYIMMCKPKD DLRKDCRLME 
FNSLINKCLR KDAESRRREL HIRTYAVIPL NDECGIIEWV NNTAGLRPIL TKLYKEKGVY 
MTGKELRQCM LPKSAALSEK LKVFREFLLP RHPPIFHEWF LRTFPDPTSW YSSRSAYCRS 
TAVMSMVGYI LGLGDRHGEN ILFDSLTGEC VHVDFNCLFN KGETFEVPEI VPFRLTHNMV 
NGMGPMGTEG LFRRACEVTM RLMRDQREPL MSVLKTFLHD PLVEWSKPVK GHSKAPLNET 
GEVVNEKAKT HVLDIEQRLQ GVIKTRNRVT GLPLSIEGHV HYLIQEATDE NLLCQMYLGW 
TPYM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.