EXOSC4 | ENSG00000178896 | NCBI 54512

Details for: EXOSC4

Gene ID: 54512

Symbol: EXOSC4

Ensembl ID: ENSG00000178896

Description: exosome component 4

Associated with

Atf4 activates genes in response to endoplasmic reticulum stress
(R-HSA-380994)
Butyrate response factor 1 (brf1) binds and destabilizes mrna
(R-HSA-450385)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Deadenylation-dependent mrna decay
(R-HSA-429914)
Ksrp (khsrp) binds and destabilizes mrna
(R-HSA-450604)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism of rna
(R-HSA-8953854)
Mrna decay by 3' to 5' exoribonuclease
(R-HSA-429958)
Perk regulates gene expression
(R-HSA-381042)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Tristetraprolin (ttp, zfp36) binds and destabilizes mrna
(R-HSA-450513)
Unfolded protein response (upr)
(R-HSA-381119)
3'-5'-rna exonuclease activity
(GO:0000175)
Cytoplasm
(GO:0005737)
Cytoplasmic exosome (rnase complex)
(GO:0000177)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Dna deamination
(GO:0045006)
Euchromatin
(GO:0000791)
Exosome (rnase complex)
(GO:0000178)
Histone mrna catabolic process
(GO:0071044)
Intracellular membrane-bounded organelle
(GO:0043231)
Maturation of 5.8s rrna
(GO:0000460)
Mrna 3'-utr au-rich region binding
(GO:0035925)
Nuclear-transcribed mrna catabolic process
(GO:0000956)
Nuclear-transcribed mrna catabolic process, exonucleolytic, 3'-5'
(GO:0034427)
Nuclear exosome (rnase complex)
(GO:0000176)
Nuclear mrna surveillance
(GO:0071028)
Nucleolar exosome (rnase complex)
(GO:0101019)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Polyadenylation-dependent snorna 3'-end processing
(GO:0071051)
Positive regulation of cell growth
(GO:0030307)
Protein binding
(GO:0005515)
Rna catabolic process
(GO:0006401)
Rna exonuclease activity
(GO:0004532)
Rna processing
(GO:0006396)
Rrna catabolic process
(GO:0016075)
Rrna processing
(GO:0006364)
U4 snrna 3'-end processing
(GO:0034475)

Other Information

Proteins

Exosome complex component RRP41

Genular Protein ID: 2654356359

Symbol: EXOS4_HUMAN

Name: Exosome complex component RRP41

UniProtKB Accession Codes:

Q9NPD3

Database IDs:

Citations:

PubMed ID: 11110791

Title: Three novel components of the human exosome.

PubMed ID: 11110791

DOI: 10.1074/jbc.m007603200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10465791

Title: The yeast exosome and human PM-Scl are related complexes of 3'-->5' exonucleases.

PubMed ID: 10465791

DOI: 10.1101/gad.13.16.2148

PubMed ID: 11719186

Title: AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.

PubMed ID: 11719186

DOI: 10.1016/s0092-8674(01)00578-5

PubMed ID: 16912217

Title: Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome.

PubMed ID: 16912217

DOI: 10.1261/rna.144606

PubMed ID: 17545563

Title: Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways.

PubMed ID: 17545563

DOI: 10.1261/rna.575107

PubMed ID: 18172165

Title: Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.

PubMed ID: 18172165

DOI: 10.1101/gad.1622708

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20531389

Title: Dis3-like 1: a novel exoribonuclease associated with the human exosome.

PubMed ID: 20531389

DOI: 10.1038/emboj.2010.122

PubMed ID: 20368444

Title: Addition of poly(A) and poly(A)-rich tails during RNA degradation in the cytoplasm of human cells.

PubMed ID: 20368444

DOI: 10.1073/pnas.0910621107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21255825

Title: The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.

PubMed ID: 21255825

DOI: 10.1016/j.cell.2011.01.001

PubMed ID: 21791617

Title: DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling.

PubMed ID: 21791617

DOI: 10.1128/mcb.01368-10

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 17174896

Title: Reconstitution, activities, and structure of the eukaryotic RNA exosome.

PubMed ID: 17174896

DOI: 10.1016/j.cell.2006.10.037

PubMed ID: 36912080

Title: The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

PubMed ID: 36912080

DOI: 10.1093/nar/gkad140

PubMed ID: 29906447

Title: Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex.

PubMed ID: 29906447

DOI: 10.1016/j.cell.2018.05.041

Sequence Information:

Length: 245
Mass: 26383
Checksum: 7A24E97897DAF313
Sequence:

MAGLELLSDQ GYRVDGRRAG ELRKIQARMG VFAQADGSAY IEQGNTKALA VVYGPHEIRG 
SRARALPDRA LVNCQYSSAT FSTGERKRRP HGDRKSCEMG LQLRQTFEAA ILTQLHPRSQ 
IDIYVQVLQA DGGTYAACVN AATLAVLDAG IPMRDFVCAC SAGFVDGTAL ADLSHVEEAA 
GGPQLALALL PASGQIALLE MDARLHEDHL ERVLEAAAQA ARDVHTLLDR VVRQHVREAS 
ILLGD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: EXOSC4

Associated with

Other Information

Three novel components of the human exosome. PubMed ID: 11110791

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The yeast exosome and human PM-Scl are related complexes of 3'--&gt;5' exonucleases. PubMed ID: 10465791

AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. PubMed ID: 11719186

Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome. PubMed ID: 16912217

Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. PubMed ID: 17545563

Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. PubMed ID: 18172165

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Dis3-like 1: a novel exoribonuclease associated with the human exosome. PubMed ID: 20531389

Addition of poly(A) and poly(A)-rich tails during RNA degradation in the cytoplasm of human cells. PubMed ID: 20368444

Initial characterization of the human central proteome. PubMed ID: 21269460

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. PubMed ID: 21255825

DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling. PubMed ID: 21791617

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Reconstitution, activities, and structure of the eukaryotic RNA exosome. PubMed ID: 17174896

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing. PubMed ID: 36912080

Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex. PubMed ID: 29906447