DDIT4 | ENSG00000168209 | NCBI 54541

Details for: DDIT4

Gene ID: 54541

Symbol: DDIT4

Ensembl ID: ENSG00000168209

Description: DNA damage inducible transcript 4

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Rna polymerase ii transcription
(R-HSA-73857)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
14-3-3 protein binding
(GO:0071889)
Apoptotic process
(GO:0006915)
Brain development
(GO:0007420)
Cellular response to dexamethasone stimulus
(GO:0071549)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Intracellular signal transduction
(GO:0035556)
Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
(GO:0042771)
Mitochondrion
(GO:0005739)
Negative regulation of glycolytic process
(GO:0045820)
Negative regulation of tor signaling
(GO:0032007)
Neuron differentiation
(GO:0030182)
Neuron migration
(GO:0001764)
Neurotrophin trk receptor signaling pathway
(GO:0048011)
Protein-containing complex disassembly
(GO:0032984)
Protein binding
(GO:0005515)
Reactive oxygen species metabolic process
(GO:0072593)
Response to hypoxia
(GO:0001666)

Other Information

Proteins

DNA damage-inducible transcript 4 protein

Genular Protein ID: 4284655485

Symbol: DDIT4_HUMAN

Name: DNA damage-inducible transcript 4 protein

UniProtKB Accession Codes:

Q9NX09 Q9H0S3

Database IDs:

Citations:

PubMed ID: 12453409

Title: REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species.

PubMed ID: 12453409

DOI: 10.1016/s1097-2765(02)00706-2

PubMed ID: 11884613

Title: Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.

PubMed ID: 11884613

DOI: 10.1128/mcb.22.7.2283-2293.2002

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14646594

Title: Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: involvement of RTP801 in amyloid beta-peptide toxicity.

PubMed ID: 14646594

DOI: 10.1038/emm.2003.53

PubMed ID: 15545625

Title: Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.

PubMed ID: 15545625

DOI: 10.1101/gad.1256804

PubMed ID: 15751966

Title: Induction of a cell stress response gene RTP801 by DNA damaging agent methyl methanesulfonate through CCAAT/enhancer binding protein.

PubMed ID: 15751966

DOI: 10.1021/bi047574r

PubMed ID: 15632201

Title: The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway.

PubMed ID: 15632201

DOI: 10.1074/jbc.c400557200

PubMed ID: 15988001

Title: Regulation of mTOR and cell growth in response to energy stress by REDD1.

PubMed ID: 15988001

DOI: 10.1128/mcb.25.14.5834-5845.2005

PubMed ID: 15592522

Title: REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase.

PubMed ID: 15592522

DOI: 10.1038/sj.onc.1208236

PubMed ID: 17005863

Title: RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation.

PubMed ID: 17005863

DOI: 10.1523/jneurosci.3292-06.2006

PubMed ID: 17379067

Title: RTP801 is a novel retinoic acid-responsive gene associated with myeloid differentiation.

PubMed ID: 17379067

DOI: 10.1016/j.exphem.2007.01.049

PubMed ID: 19557001

Title: REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase.

PubMed ID: 19557001

DOI: 10.1038/embor.2009.93

PubMed ID: 21460850

Title: TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1.

PubMed ID: 21460850

DOI: 10.1038/onc.2011.102

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 20166753

Title: Structural analysis and functional implications of the negative mTORC1 regulator REDD1.

PubMed ID: 20166753

DOI: 10.1021/bi902135e

Sequence Information:

Length: 232
Mass: 25371
Checksum: 774E941EBDD08198
Sequence:

MPSLWDRFSS SSTSSSPSSL PRTPTPDRPP RSAWGSATRE EGFDRSTSLE SSDCESLDSS 
NSGFGPEEDT AYLDGVSLPD FELLSDPEDE HLCANLMQLL QESLAQARLG SRRPARLLMP 
SQLVSQVGKE LLRLAYSEPC GLRGALLDVC VEQGKSCHSV GQLALDPSLV PTFQLTLVLR 
LDSRLWPKIQ GLFSSANSPF LPGFSQSLTL STGFRVIKKK LYSSEQLLIE EC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: DDIT4

Associated with

Other Information

REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. PubMed ID: 12453409

Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. PubMed ID: 11884613

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: involvement of RTP801 in amyloid beta-peptide toxicity. PubMed ID: 14646594

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. PubMed ID: 15545625

Induction of a cell stress response gene RTP801 by DNA damaging agent methyl methanesulfonate through CCAAT/enhancer binding protein. PubMed ID: 15751966

The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. PubMed ID: 15632201

Regulation of mTOR and cell growth in response to energy stress by REDD1. PubMed ID: 15988001

REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase. PubMed ID: 15592522

RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation. PubMed ID: 17005863

RTP801 is a novel retinoic acid-responsive gene associated with myeloid differentiation. PubMed ID: 17379067

REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase. PubMed ID: 19557001

TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1. PubMed ID: 21460850

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Structural analysis and functional implications of the negative mTORC1 regulator REDD1. PubMed ID: 20166753