RNF186 | ENSG00000178828 | NCBI 54546

Details for: RNF186

Gene ID: 54546

Symbol: RNF186

Ensembl ID: ENSG00000178828

Description: ring finger protein 186

Associated with

Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
(GO:0070059)
Metal ion binding
(GO:0046872)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein autoubiquitination
(GO:0051865)
Protein binding
(GO:0005515)
Protein k29-linked ubiquitination
(GO:0035519)
Protein k63-linked ubiquitination
(GO:0070534)
Protein localization to mitochondrion
(GO:0070585)
Regulation of autophagosome assembly
(GO:2000785)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase activity
(GO:0061630)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

RN186_HUMAN

Genular Protein ID: 2363655884

Symbol: RN186_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NXI6 Q53GE0

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23896122

Title: A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1.

PubMed ID: 23896122

DOI: 10.1016/j.cellsig.2013.07.016

PubMed ID: 31586034

Title: The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing.

PubMed ID: 31586034

DOI: 10.1074/jbc.ac119.010671

PubMed ID: 33280498

Title: RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.

PubMed ID: 33280498

DOI: 10.1080/15548627.2020.1851496

PubMed ID: 34623328

Title: Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response.

PubMed ID: 34623328

DOI: 10.1172/jci145472

Sequence Information:

Length: 227
Mass: 24145
Checksum: B856398C3C73DE3A
Sequence:

MACTKTLQQS QPISAGATTT TTAVAPAGGH SGSTECDLEC LVCREPYSCP RLPKLLACQH 
AFCAICLKLL LCVQDNTWSI TCPLCRKVTA VPGGLICSLR DHEAVVGQLA QPCTEVSLCP 
QGLVDPADLA AGHPSLVGED GQDEVSANHV AARRLAAHLL LLALLIILIG PFIYPGVLRW 
VLTFIIALAL LMSTLFCCLP STRGSCWPSS RTLFCREQKH SHISSIA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RNF186

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1. PubMed ID: 23896122

The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing. PubMed ID: 31586034

RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis. PubMed ID: 33280498

Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response. PubMed ID: 34623328