DLL4 | ENSG00000128917 | NCBI 54567

Details for: DLL4

Gene ID: 54567

Symbol: DLL4

Ensembl ID: ENSG00000128917

Description: delta like canonical Notch ligand 4

Associated with

Activated notch1 transmits signal to the nucleus
(R-HSA-2122948)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 hd domain mutants
(R-HSA-2691232)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Constitutive signaling by notch1 t(7;9)(notch1:m1580_k2555) translocation mutant
(R-HSA-2660826)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Notch2 activation and transmission of signal to the nucleus
(R-HSA-2979096)
Notch3 activation and transmission of signal to the nucleus
(R-HSA-9013507)
Notch4 activation and transmission of signal to the nucleus
(R-HSA-9013700)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 hd domain mutants in cancer
(R-HSA-2691230)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by notch1 t(7;9)(notch1:m1580_k2555) translocation mutant
(R-HSA-2660825)
Signaling by notch2
(R-HSA-1980145)
Signaling by notch3
(R-HSA-9012852)
Signaling by notch4
(R-HSA-9013694)
Angiogenesis
(GO:0001525)
Aortic valve morphogenesis
(GO:0003180)
Blood vessel lumenization
(GO:0072554)
Blood vessel remodeling
(GO:0001974)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Calcium ion binding
(GO:0005509)
Cardiac atrium morphogenesis
(GO:0003209)
Cardiac ventricle morphogenesis
(GO:0003208)
Cellular response to fibroblast growth factor stimulus
(GO:0044344)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Dorsal aorta morphogenesis
(GO:0035912)
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:1903588)
Negative regulation of cell migration involved in sprouting angiogenesis
(GO:0090051)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of endothelial cell migration
(GO:0010596)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of notch signaling pathway
(GO:0045746)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notch binding
(GO:0005112)
Notch signaling pathway
(GO:0007219)
Pericardium morphogenesis
(GO:0003344)
Plasma membrane
(GO:0005886)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of neural precursor cell proliferation
(GO:2000179)
Positive regulation of notch signaling pathway
(GO:0045747)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Regulation of neural retina development
(GO:0061074)
Regulation of neurogenesis
(GO:0050767)
Signal transduction
(GO:0007165)
T cell differentiation
(GO:0030217)
Ventral spinal cord interneuron fate commitment
(GO:0060579)
Ventricular trabecula myocardium morphogenesis
(GO:0003222)
Visual perception
(GO:0007601)

Other Information

Proteins

Delta-like protein 4

Genular Protein ID: 1603663440

Symbol: DLL4_HUMAN

Name: Delta-like protein 4

UniProtKB Accession Codes:

Q9NR61 Q3KP23 Q9NQT9

Database IDs:

Citations:

PubMed ID: 10837024

Title: Dll4, a novel Notch ligand expressed in arterial endothelium.

PubMed ID: 10837024

PubMed ID: 11134954

Title: Molecular cloning of Delta-4, a new mouse and human Notch ligand.

PubMed ID: 11134954

DOI: 10.1093/oxfordjournals.jbchem.a002832

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 17728344

Title: A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool.

PubMed ID: 17728344

DOI: 10.1242/dev.005868

PubMed ID: 20616313

Title: Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis.

PubMed ID: 20616313

DOI: 10.1161/circresaha.110.217257

PubMed ID: 26299364

Title: Heterozygous loss-of-function mutations in DLL4 cause Adams-Oliver syndrome.

PubMed ID: 26299364

DOI: 10.1016/j.ajhg.2015.07.015

Sequence Information:

Length: 685
Mass: 74605
Checksum: 6CF89D3C220ACC89
Sequence:

MAAASRSASG WALLLLVALW QQRAAGSGVF QLQLQEFINE RGVLASGRPC EPGCRTFFRV 
CLKHFQAVVS PGPCTFGTVS TPVLGTNSFA VRDDSSGGGR NPLQLPFNFT WPGTFSLIIE 
AWHAPGDDLR PEALPPDALI SKIAIQGSLA VGQNWLLDEQ TSTLTRLRYS YRVICSDNYY 
GDNCSRLCKK RNDHFGHYVC QPDGNLSCLP GWTGEYCQQP ICLSGCHEQN GYCSKPAECL 
CRPGWQGRLC NECIPHNGCR HGTCSTPWQC TCDEGWGGLF CDQDLNYCTH HSPCKNGATC 
SNSGQRSYTC TCRPGYTGVD CELELSECDS NPCRNGGSCK DQEDGYHCLC PPGYYGLHCE 
HSTLSCADSP CFNGGSCRER NQGANYACEC PPNFTGSNCE KKVDRCTSNP CANGGQCLNR 
GPSRMCRCRP GFTGTYCELH VSDCARNPCA HGGTCHDLEN GLMCTCPAGF SGRRCEVRTS 
IDACASSPCF NRATCYTDLS TDTFVCNCPY GFVGSRCEFP VGLPPSFPWV AVSLGVGLAV 
LLVLLGMVAV AVRQLRLRRP DDGSREAMNN LSDFQKDNLI PAAQLKNTNQ KKELEVDCGL 
DKSNCGKQQN HTLDYNLAPG PLGRGTMPGK FPHSDKSLGE KAPLRLHSEK PECRISAICS 
PRDSMYQSVC LISEERNECV IATEV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: DLL4

Associated with

Other Information

Dll4, a novel Notch ligand expressed in arterial endothelium. PubMed ID: 10837024

Molecular cloning of Delta-4, a new mouse and human Notch ligand. PubMed ID: 11134954

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool. PubMed ID: 17728344

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis. PubMed ID: 20616313

Heterozygous loss-of-function mutations in DLL4 cause Adams-Oliver syndrome. PubMed ID: 26299364