Details for: UGT1A8
Associated with
Other Information
Genular Protein ID: 3024977555
Symbol: UD18_HUMAN
Name: UDP-glucuronosyltransferase 1-8
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9535849
Title: Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8.
PubMed ID: 9535849
PubMed ID: 11434514
Title: Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.
PubMed ID: 11434514
PubMed ID: 12042666
Title: Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3.
PubMed ID: 12042666
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 12181437
Title: Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38).
PubMed ID: 12181437
DOI: 10.1124/mol.62.3.608
PubMed ID: 15472229
Title: Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium.
PubMed ID: 15472229
DOI: 10.1210/jc.2004-0331
PubMed ID: 15470161
Title: Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism.
PubMed ID: 15470161
PubMed ID: 16595710
Title: Human UDP-glucuronosyltransferase, UGT1A8, glucuronidates dihydrotestosterone to a monoglucuronide and further to a structurally novel diglucuronide.
PubMed ID: 16595710
PubMed ID: 17179145
Title: Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation.
PubMed ID: 17179145
PubMed ID: 18052087
Title: Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms.
PubMed ID: 18052087
DOI: 10.1021/mp700135a
PubMed ID: 18004212
Title: Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity.
PubMed ID: 18004212
PubMed ID: 18674515
Title: The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan.
PubMed ID: 18674515
PubMed ID: 18719240
Title: The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.
PubMed ID: 18719240
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19545173
Title: Structure and concentration changes affect characterization of UGT isoform-specific metabolism of isoflavones.
PubMed ID: 19545173
DOI: 10.1021/mp8002557
PubMed ID: 20610558
Title: Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.
PubMed ID: 20610558
PubMed ID: 23288867
Title: Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.
PubMed ID: 23288867
PubMed ID: 19204906
Title: Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population.
PubMed ID: 19204906
DOI: 10.1002/humu.20946
Sequence Information:
- Length: 530
- Mass: 59742
- Checksum: AD838436940F4190
- Sequence:
MARTGWTSPI PLCVSLLLTC GFAEAGKLLV VPMDGSHWFT MQSVVEKLIL RGHEVVVVMP EVSWQLGKSL NCTVKTYSTS YTLEDLDREF MDFADAQWKA QVRSLFSLFL SSSNGFFNLF FSHCRSLFND RKLVEYLKES SFDAVFLDPF DACGLIVAKY FSLPSVVFAR GIACHYLEEG AQCPAPLSYV PRILLGFSDA MTFKERVRNH IMHLEEHLFC QYFSKNALEI ASEILQTPVT AYDLYSHTSI WLLRTDFVLD YPKPVMPNMI FIGGINCHQG KPLPMEFEAY INASGEHGIV VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK WLPQNDLLGH PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR METKGAGVTL NVLEMTSEDL ENALKAVIND KSYKENIMRL SSLHKDRPVE PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW YQYHSLDVIG FLLAVVLTVA FITFKCCAYG YRKCLGKKGR VKKAHKSKTH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.