Details for: UGT1A7
Associated with
Other Information
Genular Protein ID: 868435736
Symbol: UD17_HUMAN
Name: UDP-glucuronosyltransferase 1-7
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9271343
Title: Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue.
PubMed ID: 9271343
DOI: 10.1124/mol.52.2.212
PubMed ID: 11434514
Title: Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.
PubMed ID: 11434514
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 12181437
Title: Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38).
PubMed ID: 12181437
DOI: 10.1124/mol.62.3.608
PubMed ID: 15470161
Title: Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism.
PubMed ID: 15470161
PubMed ID: 17179145
Title: Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation.
PubMed ID: 17179145
PubMed ID: 18052087
Title: Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms.
PubMed ID: 18052087
DOI: 10.1021/mp700135a
PubMed ID: 18004212
Title: Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity.
PubMed ID: 18004212
PubMed ID: 18674515
Title: The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan.
PubMed ID: 18674515
PubMed ID: 18719240
Title: The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.
PubMed ID: 18719240
PubMed ID: 20610558
Title: Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.
PubMed ID: 20610558
PubMed ID: 23360619
Title: The relative protein abundance of UGT1A alternative splice variants as a key determinant of glucuronidation activity in vitro.
PubMed ID: 23360619
PubMed ID: 11037804
Title: Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene.
PubMed ID: 11037804
PubMed ID: 19204906
Title: Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population.
PubMed ID: 19204906
DOI: 10.1002/humu.20946
Sequence Information:
- Length: 530
- Mass: 59819
- Checksum: 7D759A382AE871D3
- Sequence:
MARAGWTGLL PLYVCLLLTC GFAKAGKLLV VPMDGSHWFT MQSVVEKLIL RGHEVVVVMP EVSWQLGRSL NCTVKTYSTS YTLEDQDREF MVFADARWTA PLRSAFSLLT SSSNGIFDLF FSNCRSLFND RKLVEYLKES CFDAVFLDPF DACGLIVAKY FSLPSVVFAR GIFCHYLEEG AQCPAPLSYV PRLLLGFSDA MTFKERVWNH IMHLEEHLFC PYFFKNVLEI ASEILQTPVT AYDLYSHTSI WLLRTDFVLE YPKPVMPNMI FIGGINCHQG KPVPMEFEAY INASGEHGIV VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK WLPQNDLLGH PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR METKGAGVTL NVLEMTSEDL ENALKAVIND KSYKENIMRL SSLHKDRPVE PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW YQYHSLDVIG FLLAVVLTVA FITFKCCAYG YRKCLGKKGR VKKAHKSKTH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.