INO80 | ENSG00000128908 | NCBI 54617

Details for: INO80

Gene ID: 54617

Symbol: INO80

Ensembl ID: ENSG00000128908

Description: INO80 complex ATPase subunit

Associated with

Deubiquitination
(R-HSA-5688426)
Dna damage recognition in gg-ner
(R-HSA-5696394)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Metabolism of proteins
(R-HSA-392499)
Nucleotide excision repair
(R-HSA-5696398)
Post-translational protein modification
(R-HSA-597592)
Uch proteinases
(R-HSA-5689603)
Actin binding
(GO:0003779)
Alpha-tubulin binding
(GO:0043014)
Atp-dependent activity, acting on dna
(GO:0008094)
Atp-dependent chromatin remodeler activity
(GO:0140658)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cell division
(GO:0051301)
Cellular response to ionizing radiation
(GO:0071479)
Cellular response to uv
(GO:0034644)
Chromatin remodeling
(GO:0006338)
Cytosol
(GO:0005829)
Dna-templated transcription
(GO:0006351)
Dna binding
(GO:0003677)
Dna repair
(GO:0006281)
Double-strand break repair
(GO:0006302)
Double-strand break repair via homologous recombination
(GO:0000724)
Histone binding
(GO:0042393)
Ino80 complex
(GO:0031011)
Microtubule
(GO:0005874)
Mitotic sister chromatid segregation
(GO:0000070)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna repair
(GO:0045739)
Positive regulation of nuclear cell cycle dna replication
(GO:0010571)
Positive regulation of telomere maintenance in response to dna damage
(GO:1904507)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of cell cycle
(GO:0051726)
Regulation of chromosome organization
(GO:0033044)
Regulation of dna repair
(GO:0006282)
Regulation of dna replication
(GO:0006275)
Regulation of dna strand elongation
(GO:0060382)
Regulation of embryonic development
(GO:0045995)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Spindle
(GO:0005819)
Spindle assembly
(GO:0051225)
Telomere maintenance
(GO:0000723)
Uv-damage excision repair
(GO:0070914)

Other Information

Proteins

INO80 complex subunit A

Genular Protein ID: 3904909307

Symbol: INO80_HUMAN

Name: INO80 complex subunit A

UniProtKB Accession Codes:

Q9ULG1 A6H8X4 Q9NTG6

Database IDs:

Citations:

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16230350

Title: A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex.

PubMed ID: 16230350

DOI: 10.1074/jbc.m509128200

PubMed ID: 16298340

Title: Characterization of a human SWI2/SNF2 like protein hINO80: demonstration of catalytic and DNA binding activity.

PubMed ID: 16298340

DOI: 10.1016/j.bbrc.2005.10.206

PubMed ID: 17721549

Title: YY1 functions with INO80 to activate transcription.

PubMed ID: 17721549

DOI: 10.1038/nsmb1276

PubMed ID: 18026119

Title: A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair.

PubMed ID: 18026119

DOI: 10.1038/nsmb1332

PubMed ID: 18922472

Title: Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex.

PubMed ID: 18922472

DOI: 10.1016/j.molcel.2008.08.027

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20971067

Title: The mammalian INO80 complex is recruited to DNA damage sites in an ARP8 dependent manner.

PubMed ID: 20971067

DOI: 10.1016/j.bbrc.2010.10.066

PubMed ID: 20687897

Title: Human INO80 chromatin-remodelling complex contributes to DNA double-strand break repair via the expression of Rad54B and XRCC3 genes.

PubMed ID: 20687897

DOI: 10.1042/bj20100988

PubMed ID: 20237820

Title: Roles of human INO80 chromatin remodeling enzyme in DNA replication and chromosome segregation suppress genome instability.

PubMed ID: 20237820

DOI: 10.1007/s00018-010-0337-3

PubMed ID: 20855601

Title: INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway.

PubMed ID: 20855601

DOI: 10.1073/pnas.1008388107

PubMed ID: 21303910

Title: Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.

PubMed ID: 21303910

DOI: 10.1074/jbc.m111.222505

PubMed ID: 27939641

Title: Loss-of-function mutations in YY1AP1 lead to Grange Syndrome and a fibromuscular dysplasia-like vascular disease.

PubMed ID: 27939641

DOI: 10.1016/j.ajhg.2016.11.008

PubMed ID: 30926617

Title: BZLF1 interacts with chromatin remodelers promoting escape from latent infections with EBV.

PubMed ID: 30926617

DOI: 10.26508/lsa.201800108

Sequence Information:

Length: 1556
Mass: 176753
Checksum: 712A1EEA26D6A720
Sequence:

MASELGARDD GGCTELAKPL YLQYLERALR LDHFLRQTSA IFNRNISSDD SEDGLDDSNP 
LLPQSGDPLI QVKEEPPNSL LGETSGAGSS GMLNTYSLNG VLQSESKCDK GNLYNFSKLK 
KSRKWLKSIL LSDESSEADS QSEDDDEEEL NLSREELHNM LRLHKYKKLH QNKYSKDKEL 
QQYQYYSAGL LSTYDPFYEQ QRHLLGPKKK KFKEEKKLKA KLKKVKKKRR RDEELSSEES 
PRRHHHQTKV FAKFSHDAPP PGTKKKHLSI EQLNARRRKV WLSIVKKELP KANKQKASAR 
NLFLTNSRKL AHQCMKEVRR AALQAQKNCK ETLPRARRLT KEMLLYWKKY EKVEKEHRKR 
AEKEALEQRK LDEEMREAKR QQRKLNFLIT QTELYAHFMS RKRDMGHDGI QEEILRKLED 
SSTQRQIDIG GGVVVNITQE DYDSNHFKAQ ALKNAENAYH IHQARTRSFD EDAKESRAAA 
LRAANKSGTG FGESYSLANP SIRAGEDIPQ PTIFNGKLKG YQLKGMNWLA NLYEQGINGI 
LADEMGLGKT VQSIALLAHL AERENIWGPF LIISPASTLN NWHQEFTRFV PKFKVLPYWG 
NPHDRKVIRR FWSQKTLYTQ DAPFHVVITS YQLVVQDVKY FQRVKWQYMV LDEAQALKSS 
SSVRWKILLQ FQCRNRLLLT GTPIQNTMAE LWALLHFIMP TLFDSHEEFN EWFSKDIESH 
AENKSAIDEN QLSRLHMILK PFMLRRIKKD VENELSDKIE ILMYCQLTSR QKLLYQALKN 
KISIEDLLQS SMGSTQQAQN TTSSLMNLVM QFRKVCNHPE LFERQETWSP FHISLKPYHI 
SKFIYRHGQI RVFNHSRDRW LRVLSPFAPD YIQRSLFHRK GINEESCFSF LRFIDISPAE 
MANLMLQGLL ARWLALFLSL KASYRLHQLR SWGAPEGESH QRYLRNKDFL LGVNFPLSFP 
NLCSCPLLKS LVFSSHCKAV SGYSDQVVHQ RRSATSSLRR CLLTELPSFL CVASPRVTAV 
PLDSYCNDRS AEYERRVLKE GGSLAAKQCL LNGAPELAAD WLNRRSQFFP EPAGGLWSIR 
PQNGWSFIRI PGKESLITDS GKLYALDVLL TRLKSQGHRV LIYSQMTRMI DLLEEYMVYR 
KHTYMRLDGS SKISERRDMV ADFQNRNDIF VFLLSTRAGG LGINLTAADT VIFYDSDWNP 
TVDQQAMDRA HRLGQTKQVT VYRLICKGTI EERILQRAKE KSEIQRMVIS GGNFKPDTLK 
PKEVVSLLLD DEELEKKLRL RQEEKRQQEE TNRVKERKRK REKYAEKKKK EDELDGKRRK 
EGVNLVIPFV PSADNSNLSA DGDDSFISVD SAMPSPFSEI SISSELHTGS IPLDESSSDM 
LVIVDDPASS APQSRATNSP ASITGSVSDT VNGISIQEMP AAGRGHSARS RGRPKGSGST 
AKGAGKGRSR KSTAGSAAAM AGAKAGAAAA SAAAYAAYGY NVSKGISASS PLQTSLVRPA 
GLADFGPSSA SSPLSSPLSK GNNVPGNPKN LHMTSSLAPD SLVRKQGKGT NPSGGR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: INO80

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10574462

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. PubMed ID: 16230350

Characterization of a human SWI2/SNF2 like protein hINO80: demonstration of catalytic and DNA binding activity. PubMed ID: 16298340

YY1 functions with INO80 to activate transcription. PubMed ID: 17721549

A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. PubMed ID: 18026119

Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. PubMed ID: 18922472

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

The mammalian INO80 complex is recruited to DNA damage sites in an ARP8 dependent manner. PubMed ID: 20971067

Human INO80 chromatin-remodelling complex contributes to DNA double-strand break repair via the expression of Rad54B and XRCC3 genes. PubMed ID: 20687897

Roles of human INO80 chromatin remodeling enzyme in DNA replication and chromosome segregation suppress genome instability. PubMed ID: 20237820

INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway. PubMed ID: 20855601

Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. PubMed ID: 21303910

Loss-of-function mutations in YY1AP1 lead to Grange Syndrome and a fibromuscular dysplasia-like vascular disease. PubMed ID: 27939641

BZLF1 interacts with chromatin remodelers promoting escape from latent infections with EBV. PubMed ID: 30926617