Details for: PAF1

Gene ID: 54623

Symbol: PAF1

Ensembl ID: ENSG00000006712

Description: PAF1 homolog, Paf1/RNA polymerase II complex component

Associated with

Other Information

Genular Protein ID: 3061174906

Symbol: PAF1_HUMAN

Name: RNA polymerase II-associated factor 1 homolog

UniProtKB Accession Codes:

Q8N7H5 M0QX35 O75239 Q9H166 Q9NUU9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 20 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 9 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16491129

Title: The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis.

PubMed ID: 16491129

DOI: 10.1038/sj.onc.1209353

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16024656

Title: The human PAF complex coordinates transcription with events downstream of RNA synthesis.

PubMed ID: 16024656

DOI: 10.1101/gad.1292105

PubMed ID: 16307923

Title: Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.

PubMed ID: 16307923

DOI: 10.1016/j.molcel.2005.09.025

PubMed ID: 15923622

Title: The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II.

PubMed ID: 15923622

DOI: 10.1128/mcb.25.12.5052-5060.2005

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19410543

Title: RAD6-mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells.

PubMed ID: 19410543

DOI: 10.1016/j.cell.2009.02.027

PubMed ID: 19952111

Title: DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation.

PubMed ID: 19952111

DOI: 10.1101/gad.1834709

PubMed ID: 20541477

Title: The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis.

PubMed ID: 20541477

DOI: 10.1016/j.ccr.2010.04.012

PubMed ID: 20178742

Title: The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.

PubMed ID: 20178742

DOI: 10.1016/j.cell.2009.12.050

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21329879

Title: Transcriptional activators enhance polyadenylation of mRNA precursors.

PubMed ID: 21329879

DOI: 10.1016/j.molcel.2011.01.022

PubMed ID: 22419161

Title: Suppression of the antiviral response by an influenza histone mimic.

PubMed ID: 22419161

DOI: 10.1038/nature10892

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30550790

Title: Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.

PubMed ID: 30550790

DOI: 10.1016/j.cell.2018.11.028

PubMed ID: 30367041

Title: A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma.

PubMed ID: 30367041

DOI: 10.1038/s41467-018-06862-2

Sequence Information:

  • Length: 531
  • Mass: 59976
  • Checksum: 756F800AA64255D6
  • Sequence:
    • MAPTIQTQAQ REDGHRPNSH RTLPERSGVV CRVKYCNSLP DIPFDPKFIT YPFDQNRFVQ 
YKATSLEKQH KHDLLTEPDL GVTIDLINPD TYRIDPNVLL DPADEKLLEE EIQAPTSSKR 
SQQHAKVVPW MRKTEYISTE FNRYGISNEK PEVKIGVSVK QQFTEEEIYK DRDSQITAIE 
KTFEDAQKSI SQHYSKPRVT PVEVMPVFPD FKMWINPCAQ VIFDSDPAPK DTSGAAALEM 
MSQAMIRGMM DEEGNQFVAY FLPVEETLKK RKRDQEEEMD YAPDDVYDYK IAREYNWNVK 
NKASKGYEEN YFFIFREGDG VYYNELETRV RLSKRRAKAG VQSGTNALLV VKHRDMNEKE 
LEAQEARKAQ LENHEPEEEE EEEMETEEKE AGGSDEEQEK GSSSEKEGSE DEHSGSESER 
EEGDRDEASD KSGSGEDESS EDEARAARDK EEIFGSDADS EDDADSDDED RGQAQGGSDN 
DSDSGSNGGG QRSRSHSRSA SPFPSGSEHS AQEDGSEAAA SDSSEADSDS D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.