Details for: MINDY2

Gene ID: 54629

Symbol: MINDY2

Ensembl ID: ENSG00000128923

Description: MINDY lysine 48 deubiquitinase 2

Associated with

  • Biological_process
    (GO:0008150)
  • Cysteine-type carboxypeptidase activity
    (GO:0016807)
  • Cysteine-type deubiquitinase activity
    (GO:0004843)
  • K6-linked polyubiquitin modification-dependent protein binding
    (GO:0071796)
  • K11-linked polyubiquitin modification-dependent protein binding
    (GO:0071795)
  • K48-linked deubiquitinase activity
    (GO:1990380)
  • K48-linked polyubiquitin modification-dependent protein binding
    (GO:0036435)
  • K63-linked polyubiquitin modification-dependent protein binding
    (GO:0070530)
  • Nucleoplasm
    (GO:0005654)
  • Protein k48-linked deubiquitination
    (GO:0071108)
  • Proteolysis
    (GO:0006508)

Other Information

Genular Protein ID: 3656361139

Symbol: MINY2_HUMAN

Name: Protein FAM63B

UniProtKB Accession Codes:

Q8NBR6 B2RTT8 Q9ULQ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SASBDB 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10574461

Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.

PubMed ID: 10574461

DOI: 10.1093/dnares/6.5.329

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27292798

Title: MINDY-1 is a member of an evolutionarily conserved and structurally distinct new family of deubiquitinating enzymes.

PubMed ID: 27292798

DOI: 10.1016/j.molcel.2016.05.009

PubMed ID: 28082312

Title: A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains.

PubMed ID: 28082312

DOI: 10.15252/embr.201643205

Sequence Information:

  • Length: 621
  • Mass: 67106
  • Checksum: ED97D0BBCA6DC421
  • Sequence:
    • MESSPESLQP LEHGVAAGPA SGTGSSQEGL QETRLAAGDG PGVWAAETSG GNGLGAAAAR 
RSLPDSASPA GSPEVPGPCS SSAGLDLKDS GLESPAAAEA PLRGQYKVTA SPETAVAGVG 
HELGTAGDAG ARPDLAGTCQ AELTAAGSEE PSSAGGLSSS CSDPSPPGES PSLDSLESFS 
NLHSFPSSCE FNSEEGAENR VPEEEEGAAV LPGAVPLCKE EEGEETAQVL AASKERFPGQ 
SVYHIKWIQW KEENTPIITQ NENGPCPLLA ILNVLLLAWK VKLPPMMEII TAEQLMEYLG 
DYMLDAKPKE ISEIQRLNYE QNMSDAMAIL HKLQTGLDVN VRFTGVRVFE YTPECIVFDL 
LDIPLYHGWL VDPQIDDIVK AVGNCSYNQL VEKIISCKQS DNSELVSEGF VAEQFLNNTA 
TQLTYHGLCE LTSTVQEGEL CVFFRNNHFS TMTKYKGQLY LLVTDQGFLT EEKVVWESLH 
NVDGDGNFCD SEFHLRPPSD PETVYKGQQD QIDQDYLMAL SLQQEQQSQE INWEQIPEGI 
SDLELAKKLQ EEEDRRASQY YQEQEQAAAA AAAASTQAQQ GQPAQASPSS GRQSGNSERK 
RKEPREKDKE KEKEKNSCVI L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.