Details for: Nphs1

Gene ID: 54631

Symbol: Nphs1

Ensembl ID: ENSMUSG00000006649

Description: nephrosis 1, nephrin

Associated with

Other Information

Genular Protein ID: 3425432899

Symbol: NPHN_MOUSE

Name: Nephrin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10504499

Title: Nephrin localizes to the slit pore of the glomerular epithelial cell.

PubMed ID: 10504499

DOI: 10.1046/j.1523-1755.1999.00719.x

PubMed ID: 10820162

Title: Primary structure of mouse and rat nephrin cDNA and structure and expression of the mouse gene.

PubMed ID: 10820162

DOI: 10.1681/asn.v116991

PubMed ID: 12039968

Title: Determinants of vascular permeability in the kidney glomerulus.

PubMed ID: 12039968

DOI: 10.1074/jbc.m204806200

PubMed ID: 19887377

Title: Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system.

PubMed ID: 19887377

DOI: 10.1074/jbc.m109.060657

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 12538735

Title: Alternatively used promoters and distinct elements direct tissue-specific expression of nephrin.

PubMed ID: 12538735

DOI: 10.1097/01.asn.0000043081.65110.c4

PubMed ID: 11733379

Title: CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain.

PubMed ID: 11733379

DOI: 10.1016/s0002-9440(10)63080-5

PubMed ID: 11136707

Title: The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death.

PubMed ID: 11136707

DOI: 10.1093/hmg/10.1.1

PubMed ID: 11733557

Title: Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin.

PubMed ID: 11733557

DOI: 10.1172/jci12849

PubMed ID: 12424224

Title: NEPH1 defines a novel family of podocin interacting proteins.

PubMed ID: 12424224

DOI: 10.1096/fj.02-0242fje

PubMed ID: 12660326

Title: Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1.

PubMed ID: 12660326

DOI: 10.1097/01.asn.0000057853.05686.89

PubMed ID: 15843475

Title: NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases.

PubMed ID: 15843475

DOI: 10.1681/asn.2004060439

PubMed ID: 17537921

Title: Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes.

PubMed ID: 17537921

DOI: 10.1073/pnas.0700917104

PubMed ID: 18752272

Title: Expression of kin of irregular chiasm-like 3/mKirre in proprioceptive neurons of the dorsal root ganglia and its interaction with nephrin in muscle spindles.

PubMed ID: 18752272

DOI: 10.1002/cne.21838

PubMed ID: 19470472

Title: A role for nephrin, a renal protein, in vertebrate skeletal muscle cell fusion.

PubMed ID: 19470472

DOI: 10.1073/pnas.0904398106

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 1256
  • Mass: 136336
  • Checksum: 339A670F2AF000A2
  • Sequence:
  • MGAKEATVRG PGASPVHRTC HLIPLLLAGM LTTGLAQSPV PTSAPRGFWA LSENLTVVEG 
    STVKLWCGVR APGSVVQWAK DGLLLGPNPK IPGFPRYSLE GDSAKGEFHL LIEACDLSDD 
    AEYECQVGRS ELGPELVSPS VILSILVSPK VLQLTPEAGS TVTWVAGQEY VVTCVSGDAK 
    PAPDIIFIQG GRTVEDVSSS VNEGSEEKLF FTEAEARVTP QSSDNGQLLV CEGSNPALAT 
    PIKASFTMNI LFPPGPPVID WPGLNEGHVR AGENLELPCI ARGGNPPATL QWLKNGKPVS 
    IAWGTEHAQA VAHSVLVMTV RPEDHGARLS CQSYNSVSAE TQERSITLQV TFPPSAVTIL 
    GSTSQSENKN VTLCCLTKSS RPRVLLRWWL GGRQLLPTDE TVMDGLHGGH ISMSNLTLLV 
    KREDNGLSLT CEAFSDAFSK ETFKKSLTLN VKYPAQKLWI EGPPEGQSIR TGTRVRLVCL 
    AIGGNPEPSL TWLKDSRPVN DPRQSQEPRR VQLGSVEKSG STFSRELVLI IGPPDNLAKF 
    SCKAGQLSAS TQLVVQFPPT NLTILANSSA LRPGDALNLT CVSISSNPPV NLSLDKEGER 
    LDDVAAKPQS APFKGSAASR SVFLRVSSRD HGHRVTCRAH SEALRETVSS FYRLNVLYPP 
    EFLGEQVRAV TVVEQGQALL PVSVSANPAP EAFNWTFRGY RLSPAGGPRH RILSGGALQL 
    WNVTRADDGF YQLHCQNSEG TAEALLKLDV HYAPTIRALK DPTEVNVGGS VDIVCTVDAN 
    PILPEMFSWE RLGEDEEELN LDDMEKMSKG STGRLRIRQA KLSQAGAYQC IVDNGVAPAA 
    RGLVRLVVRF APQVDHPTPL TKVAAAGDST SSATLHCRAR GVPNIDFTWT KNGVPLDLQD 
    PRYTEHKYHQ GVVHSSLLTI ANVSAAQDYA LFKCTATNAL GSDHTNIQLV SISRPDPPLG 
    LKVVSVSPHS VGLEWKPGFD GGLPQRFQIR YEALESPGFL YMDVLPAQAT TFTLTGLKPS 
    TRYRIWLLAS NALGDSGLTD KGIQVSITTP GLDQAPEDTD QPLPTEQPPG PPRLPLLPVL 
    FAVGGLLLLS NASCVGGLLW RRRLRRLAEE ISEKTEAGSE EDRIRNEYEE SQWTGDRDTR 
    SSTVSTAEVD PHYYSMRDFS PQLPPTLEEV SYRQAFTGIE DEDMAFPGHL YDEVERVYGP 
    PGVWGPLYDE VQMDPYDLRW PEVKYEDPRG IYDQVAADMD AGEPGSLPFE LRGHLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.