Details for: Pdgfc

Gene ID: 54635

Symbol: Pdgfc

Ensembl ID: ENSMUSG00000028019

Description: platelet-derived growth factor, C polypeptide

Associated with

Other Information

Genular Protein ID: 2566674562

Symbol: PDGFC_MOUSE

Name: Platelet-derived growth factor C

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10960785

Title: The mouse Pdgfc gene: dynamic expression in embryonic tissues during organogenesis.

PubMed ID: 10960785

DOI: 10.1016/s0925-4773(00)00425-1

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10806482

Title: PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.

PubMed ID: 10806482

DOI: 10.1038/35010579

PubMed ID: 11297552

Title: Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor.

PubMed ID: 11297552

DOI: 10.1074/jbc.m101056200

PubMed ID: 11313995

Title: PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors.

PubMed ID: 11313995

DOI: 10.1038/sj.onc.1204133

PubMed ID: 11744381

Title: Expression analysis of PDGF-C in adult and developing mouse tissues.

PubMed ID: 11744381

DOI: 10.1016/s0925-4773(01)00560-3

PubMed ID: 12875986

Title: Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy.

PubMed ID: 12875986

DOI: 10.1016/s0002-9440(10)63694-2

PubMed ID: 12972405

Title: Modulation of PDGF-C and PDGF-D expression during bleomycin-induced lung fibrosis.

PubMed ID: 12972405

DOI: 10.1152/ajplung.00083.2003

PubMed ID: 15061151

Title: PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle.

PubMed ID: 15061151

DOI: 10.1161/01.atv.0000120785.82268.8b

PubMed ID: 15207812

Title: PDGF signaling in cells and mice.

PubMed ID: 15207812

DOI: 10.1016/j.cytogfr.2004.03.003

PubMed ID: 15372073

Title: Tissue plasminogen activator is a potent activator of PDGF-CC.

PubMed ID: 15372073

DOI: 10.1038/sj.emboj.7600397

PubMed ID: 15361870

Title: A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling.

PubMed ID: 15361870

DOI: 10.1038/ng1415

PubMed ID: 15757957

Title: Linkage between elevated PDGF-C expression and myocardial fibrogenesis in coxsackievirus B3-induced chronic myocarditis.

PubMed ID: 15757957

DOI: 10.1093/eurheartj/ehi201

PubMed ID: 15911618

Title: Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator.

PubMed ID: 15911618

DOI: 10.1074/jbc.m503388200

PubMed ID: 17066417

Title: PDGF-C controls proliferation and is down-regulated by retinoic acid in mouse embryonic palatal mesenchymal cells.

PubMed ID: 17066417

DOI: 10.1002/bdrb.20094

PubMed ID: 16344272

Title: Aberrant expression of PDGF ligands and receptors in the tumor prone ovary of follitropin receptor knockout (FORKO) mouse.

PubMed ID: 16344272

DOI: 10.1093/carcin/bgi305

PubMed ID: 16443219

Title: Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines.

PubMed ID: 16443219

DOI: 10.1016/j.yexcr.2005.11.035

PubMed ID: 16951379

Title: Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts.

PubMed ID: 16951379

DOI: 10.4049/jimmunol.177.6.4141

PubMed ID: 18184860

Title: PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis.

PubMed ID: 18184860

DOI: 10.1681/asn.2007030290

Sequence Information:

  • Length: 345
  • Mass: 38741
  • Checksum: 3A58A1F701B84EA2
  • Sequence:
  • MLLLGLLLLT SALAGQRTGT RAESNLSSKL QLSSDKEQNG VQDPRHERVV TISGNGSIHS 
    PKFPHTYPRN MVLVWRLVAV DENVRIQLTF DERFGLEDPE DDICKYDFVE VEEPSDGSVL 
    GRWCGSGTVP GKQTSKGNHI RIRFVSDEYF PSEPGFCIHY SIIMPQVTET TSPSVLPPSS 
    LSLDLLNNAV TAFSTLEELI RYLEPDRWQV DLDSLYKPTW QLLGKAFLYG KKSKVVNLNL 
    LKEEVKLYSC TPRNFSVSIR EELKRTDTIF WPGCLLVKRC GGNCACCLHN CNECQCVPRK 
    VTKKYHEVLQ LRPKTGVKGL HKSLTDVALE HHEECDCVCR GNAGG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.