UGT1A4 | ENSG00000244474 | NCBI 54657

Details for: UGT1A4

Gene ID: 54657

Symbol: UGT1A4

Ensembl ID: ENSG00000244474

Description: UDP glucuronosyltransferase family 1 member A4

Associated with

Aspirin adme
(R-HSA-9749641)
Biological oxidations
(R-HSA-211859)
Defective ugt1a4 causes hyperbilirubinemia
(R-HSA-5579016)
Disease
(R-HSA-1643685)
Diseases of metabolism
(R-HSA-5668914)
Drug adme
(R-HSA-9748784)
Glucuronidation
(R-HSA-156588)
Heme degradation
(R-HSA-189483)
Metabolic disorders of biological oxidation enzymes
(R-HSA-5579029)
Metabolism
(R-HSA-1430728)
Metabolism of porphyrins
(R-HSA-189445)
Phase ii - conjugation of compounds
(R-HSA-156580)
Bilirubin conjugation
(GO:0006789)
Cellular glucuronidation
(GO:0052695)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Glucuronosyltransferase activity
(GO:0015020)
Heme catabolic process
(GO:0042167)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Retinoic acid binding
(GO:0001972)
Vitamin d3 metabolic process
(GO:0070640)

Other Information

Proteins

Bilirubin-specific UDPGT isozyme 2

Genular Protein ID: 2594410726

Symbol: UD14_HUMAN

Name: Bilirubin-specific UDPGT isozyme 2

UniProtKB Accession Codes:

P22310 B2R937 B8K288 Q5DT00

Database IDs:

Citations:

PubMed ID: 1898728

Title: Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells.

PubMed ID: 1898728

DOI: 10.1016/s0021-9258(17)35280-8

PubMed ID: 1339448

Title: A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.

PubMed ID: 1339448

DOI: 10.1016/s0021-9258(19)50724-4

PubMed ID: 11434514

Title: Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.

PubMed ID: 11434514

DOI: 10.1097/00008571-200106000-00011

PubMed ID: 14672974

Title: Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.

PubMed ID: 14672974

DOI: 10.1101/gr.1225204

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18004212

Title: Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity.

PubMed ID: 18004212

DOI: 10.1097/fpc.0b013e3282f1f118

PubMed ID: 17179145

Title: Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation.

PubMed ID: 17179145

DOI: 10.1074/jbc.m609417200

PubMed ID: 18177842

Title: Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation.

PubMed ID: 18177842

DOI: 10.1016/j.bcp.2007.11.008

PubMed ID: 18719240

Title: The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.

PubMed ID: 18719240

DOI: 10.1124/dmd.108.022731

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20610558

Title: Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.

PubMed ID: 20610558

DOI: 10.1124/dmd.110.034835

PubMed ID: 23288867

Title: Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.

PubMed ID: 23288867

DOI: 10.1124/dmd.112.049072

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19204906

Title: Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population.

PubMed ID: 19204906

DOI: 10.1002/humu.20946

PubMed ID: 24641623

Title: Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability.

PubMed ID: 24641623

DOI: 10.1210/en.2013-2013

Sequence Information:

Length: 534
Mass: 60025
Checksum: AB745D46F57538BE
Sequence:

MARGLQVPLP RLATGLLLLL SVQPWAESGK VLVVPTDGSP WLSMREALRE LHARGHQAVV 
LTPEVNMHIK EEKFFTLTAY AVPWTQKEFD RVTLGYTQGF FETEHLLKRY SRSMAIMNNV 
SLALHRCCVE LLHNEALIRH LNATSFDVVL TDPVNLCGAV LAKYLSIPAV FFWRYIPCDL 
DFKGTQCPNP SSYIPKLLTT NSDHMTFLQR VKNMLYPLAL SYICHTFSAP YASLASELFQ 
REVSVVDLVS YASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANGKPLSQE FEAYINASGE 
HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT ILVKWLPQND 
LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD NAKRMETKGA GVTLNVLEMT 
SEDLENALKA VINDKSYKEN IMRLSSLHKD RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH 
DLTWYQYHSL DVIGFLLAVV LTVAFITFKC CAYGYRKCLG KKGRVKKAHK SKTH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: UGT1A4

Associated with

Other Information

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells. PubMed ID: 1898728

A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. PubMed ID: 1339448

Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. PubMed ID: 11434514

Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. PubMed ID: 14672974

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity. PubMed ID: 18004212

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. PubMed ID: 17179145

Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation. PubMed ID: 18177842

The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases. PubMed ID: 18719240

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro. PubMed ID: 20610558

Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol. PubMed ID: 23288867

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. PubMed ID: 19204906

Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability. PubMed ID: 24641623