Details for: TMEM106B

Gene ID: 54664

Symbol: TMEM106B

Ensembl ID: ENSG00000106460

Description: transmembrane protein 106B

Associated with

Other Information

Genular Protein ID: 1555004101

Symbol: T106B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NUM4 A4D108 Q53FL9 Q8N4L0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 19 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 40 PDBsum 21 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20154673

Title: Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.

PubMed ID: 20154673

DOI: 10.1038/ng.536

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21178100

Title: TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers.

PubMed ID: 21178100

DOI: 10.1212/wnl.0b013e31820a0e3b

PubMed ID: 22511793

Title: Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration.

PubMed ID: 22511793

DOI: 10.1074/jbc.m112.365098

PubMed ID: 22895706

Title: TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.

PubMed ID: 22895706

DOI: 10.1523/jneurosci.0521-12.2012

PubMed ID: 23136129

Title: The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function.

PubMed ID: 23136129

DOI: 10.1093/hmg/dds475

PubMed ID: 23742080

Title: TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.

PubMed ID: 23742080

DOI: 10.1111/jnc.12329

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24488309

Title: TMEM106B: a strong FTLD disease modifier.

PubMed ID: 24488309

DOI: 10.1007/s00401-014-1249-3

PubMed ID: 24442578

Title: TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.

PubMed ID: 24442578

DOI: 10.1007/s00401-013-1239-x

PubMed ID: 24385136

Title: TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia.

PubMed ID: 24385136

DOI: 10.1007/s00401-013-1240-4

PubMed ID: 24357581

Title: The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes.

PubMed ID: 24357581

DOI: 10.1002/embj.201385857

PubMed ID: 25066864

Title: Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B.

PubMed ID: 25066864

DOI: 10.1016/j.mcn.2014.07.006

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 28728022

Title: Loss of TMEM106B ameliorates lysosomal and frontotemporal dementia-related phenotypes in progranulin-deficient mice.

PubMed ID: 28728022

DOI: 10.1016/j.neuron.2017.06.026

PubMed ID: 33333024

Title: Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses.

PubMed ID: 33333024

DOI: 10.1016/j.cell.2020.12.004

PubMed ID: 33686287

Title: Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2.

PubMed ID: 33686287

DOI: 10.1038/s41588-021-00805-2

PubMed ID: 35247328

Title: Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases.

PubMed ID: 35247328

DOI: 10.1016/j.cell.2022.02.026

PubMed ID: 35344984

Title: Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.

PubMed ID: 35344984

DOI: 10.1038/s41586-022-04670-9

PubMed ID: 35344985

Title: Age-dependent formation of TMEM106B amyloid filaments in human brains.

PubMed ID: 35344985

DOI: 10.1038/s41586-022-04650-z

PubMed ID: 37421949

Title: TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry.

PubMed ID: 37421949

DOI: 10.1016/j.cell.2023.06.005

PubMed ID: 29186371

Title: A recurrent de novo mutation in TMEM106B causes hypomyelinating leukodystrophy.

PubMed ID: 29186371

DOI: 10.1093/brain/awx314

PubMed ID: 29444210

Title: The recurrent mutation in TMEM106B also causes hypomyelinating leukodystrophy in China and is a CpG hotspot.

PubMed ID: 29444210

DOI: 10.1093/brain/awy029

Sequence Information:

  • Length: 274
  • Mass: 31127
  • Checksum: 906C923986DC04E6
  • Sequence:
    • MGKSLSHLPL HSSKEDAYDG VTSENMRNGL VNSEVHNEDG RNGDVSQFPY VEFTGRDSVT 
CPTCQGTGRI PRGQENQLVA LIPYSDQRLR PRRTKLYVMA SVFVCLLLSG LAVFFLFPRS 
IDVKYIGVKS AYVSYDVQKR TIYLNITNTL NITNNNYYSV EVENITAQVQ FSKTVIGKAR 
LNNITIIGPL DMKQIDYTVP TVIAEEMSYM YDFCTLISIK VHNIVLMMQV TVTTTYFGHS 
EQISQERYQY VDCGRNTTYQ LGQSEYLNVL QPQQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.