Atp8b1 | ENSMUSG00000039529 | NCBI 54670

Details for: Atp8b1

Gene ID: 54670

Symbol: Atp8b1

Ensembl ID: ENSMUSG00000039529

Description: ATPase, class I, type 8B, member 1

Associated with

Ion channel transport
(R-MMU-983712)
Ion transport by p-type atpases
(R-MMU-936837)
Transport of small molecules
(R-MMU-382551)
Aminophospholipid flippase activity
(GO:0015247)
Aminophospholipid transport
(GO:0015917)
Apical plasma membrane
(GO:0016324)
Apical protein localization
(GO:0045176)
Atpase-coupled intramembrane lipid transporter activity
(GO:0140326)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Bile acid and bile salt transport
(GO:0015721)
Bile acid metabolic process
(GO:0008206)
Brush border membrane
(GO:0031526)
Cardiolipin binding
(GO:1901612)
Cell projection
(GO:0042995)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Golgi apparatus
(GO:0005794)
Golgi organization
(GO:0007030)
Inner ear receptor cell development
(GO:0060119)
Lipid transport
(GO:0006869)
Lipid transporter activity
(GO:0005319)
Magnesium ion binding
(GO:0000287)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of dna-templated transcription
(GO:0045892)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Organic anion transport
(GO:0015711)
Phosphatidylcholine flippase activity
(GO:0140345)
Phosphatidylserine flippase activity
(GO:0140346)
Phospholipid-translocating atpase complex
(GO:1990531)
Phospholipid translocation
(GO:0045332)
Phospholipid transport
(GO:0015914)
Plasma membrane
(GO:0005886)
Regulation of chloride transport
(GO:2001225)
Regulation of microvillus assembly
(GO:0032534)
Regulation of plasma membrane organization
(GO:1903729)
Sensory perception of sound
(GO:0007605)
Stereocilium
(GO:0032420)
Trans-golgi network
(GO:0005802)
Transporter activity
(GO:0005215)
Vestibulocochlear nerve formation
(GO:0021650)
Xenobiotic transmembrane transport
(GO:0006855)

Other Information

Proteins

ATPase class I type 8B member 1

Genular Protein ID: 973115551

Symbol: AT8B1_MOUSE

Name: ATPase class I type 8B member 1

UniProtKB Accession Codes:

Q148W0 Q3U010 Q6R964

Database IDs:

Citations:

PubMed ID: 14976163

Title: A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion.

PubMed ID: 14976163

DOI: 10.1093/hmg/ddh100

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19478059

Title: ATP8B1 is essential for maintaining normal hearing.

PubMed ID: 19478059

DOI: 10.1073/pnas.0807919106

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20852622

Title: Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia.

PubMed ID: 20852622

DOI: 10.1038/nm.2213

PubMed ID: 20126555

Title: Strain background modifies phenotypes in the ATP8B1-deficient mouse.

PubMed ID: 20126555

DOI: 10.1371/journal.pone.0008984

PubMed ID: 21820390

Title: Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.

PubMed ID: 21820390

DOI: 10.1053/j.gastro.2011.07.042

PubMed ID: 21475228

Title: The flip side of cardiolipin import.

PubMed ID: 21475228

DOI: 10.1038/nm0411-413a

PubMed ID: 26416959

Title: ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization.

PubMed ID: 26416959

DOI: 10.1083/jcb.201505118

PubMed ID: 30018401

Title: Proteomic Analysis and Functional Characterization of P4-ATPase Phospholipid Flippases from Murine Tissues.

PubMed ID: 30018401

DOI: 10.1038/s41598-018-29108-z

Sequence Information:

Length: 1251
Mass: 143798
Checksum: 394920189075875D
Sequence:

MSTERDSETT FDEESQPNDE VVPYSDDETE DELEDQGSTV EPEQNRVNRE AEKKRETFRK 
DCTWQVKAND RKFHEQPHFM NTKFFCIKES KYASNAIKTY KYNGFTFLPM NLFEQFKRAA 
NFYFLILLIL QAIPQISTLA WYTTLVPLLL VLGITAIKDL VDDVARHKMD KEINNRTCEV 
IKDGRFKIIK WKDIQVGDVI RLKKNDFIPA DILLLSSSEP NSLCYVETAE LDGETNLKFK 
MALEITDQYL QIEDNLATFD GFIECEEPNN RLDKFTGTLF WKNQSFPLDA DKILLRGCVI 
RNTDVCHGLV IFAGADTKIM KNSGKTRFKR TKIDYLMNYM VYTIFIVLIL VSAGLAIGHA 
YWEAQVGNYS WYLYDGENAT PSYRGFLNFW GYIIVLNTMV PISLYVSVEV IRLGQSHFIN 
WDLQMYYAEK DTPAKARTTT LNEQLGQIHY IFSDKTGTLT QNIMTFKKCC INGTIYGDHR 
DASQHSHSKI ELVDFSWNTF ADGKLAFYDH YLIEQIQSGK EPEVRQFFFL LSICHTVMVD 
RIDGQINYQA ASPDEGALVN AARNFGFAFL ARTQNTITVS ELGSERTYNV LAILDFNSDR 
KRMSIIVRTP EGSIRLYCKG ADTVIYERLH RMNPTKQETQ DALDIFASET LRTLCLCYKE 
IEEKEFTEWN NKFMAASVAS SNRDEALDKV YEEIEKDLIL LGATAIEDKL QDGVPETISK 
LAKADIKIWV LTGDKKETAE NIGFACELLT EDTTICYGED INSLLHTRME NQRNRGGVSA 
KFAPPVYEPF FPPGENRALI ITGSWLNEIL LEKKTKRSKI LKLKFPRTEE ERRMRSQSRR 
RLEEKKEQRQ KNFVDLACEC SAVICCRVTP KQKAMVVDLV KRYKKAITLA IGDGANDVNM 
IKTAHIGVGI SGQEGMQAVM SSDYSFAQFR YLQRLLLVHG RWSYIRMCKF LRYFFYKNFA 
FTLVHFWYSF FNGYSAQTAY EDWFITLYNV LYSSLPVLLM GLLDQDVSDK LSLRFPGLYV 
VGQRDLLFNY KRFFVSLLHG VLTSMVLFFI PLGAYLQTVG QDGEAPSDYQ SFAVTVASAL 
VITVNFQIGL DTSYWTFVNA FSIFGSIALY FGIMFDFHSA GIHVLFPSAF QFTGTASNAL 
RQPYIWLTII LTVAVCLLPV VAIRFLSMTI WPSESDKIQK HRKRLKAEEQ WKRRQSVFRR 
GVSSRRSAYA FSHQRGYADL ISSGRSIRKK RSPLDAIIAD GTAEYRRTVE S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Atp8b1

Associated with

Other Information

A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion. PubMed ID: 14976163

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

ATP8B1 is essential for maintaining normal hearing. PubMed ID: 19478059

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia. PubMed ID: 20852622

Strain background modifies phenotypes in the ATP8B1-deficient mouse. PubMed ID: 20126555

Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity. PubMed ID: 21820390

The flip side of cardiolipin import. PubMed ID: 21475228

ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization. PubMed ID: 26416959

Proteomic Analysis and Functional Characterization of P4-ATPase Phospholipid Flippases from Murine Tissues. PubMed ID: 30018401