Crtam | ENSMUSG00000032021 | NCBI 54698

Details for: Crtam

Gene ID: 54698

Symbol: Crtam

Ensembl ID: ENSMUSG00000032021

Description: cytotoxic and regulatory T cell molecule

Associated with

Adaptive immune system
(R-MMU-1280218)
Immune system
(R-MMU-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-MMU-198933)
Adaptive immune response
(GO:0002250)
Cell adhesion
(GO:0007155)
Cell recognition
(GO:0008037)
Detection of stimulus
(GO:0051606)
Detection of tumor cell
(GO:0002355)
Establishment of t cell polarity
(GO:0001768)
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0007157)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Immunological synapse
(GO:0001772)
Lymphocyte migration into lymphoid organs
(GO:0097021)
Membrane
(GO:0016020)
Negative regulation of activated t cell proliferation
(GO:0046007)
Plasma membrane
(GO:0005886)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of natural killer cell mediated cytotoxicity
(GO:0045954)
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
(GO:0002860)
Positive regulation of type ii interferon production
(GO:0032729)
Protein binding
(GO:0005515)
Regulation of cd8-positive, alpha-beta t cell activation
(GO:2001185)
Regulation of t cell activation
(GO:0050863)
Regulation of t cell differentiation
(GO:0045580)
Signaling receptor binding
(GO:0005102)

Other Information

Proteins

Cytotoxic and regulatory T-cell molecule

Genular Protein ID: 3144335162

Symbol: CRTAM_MOUSE

Name: Cytotoxic and regulatory T-cell molecule

UniProtKB Accession Codes:

Q149L7 A0A087WPL6 M0QWH9 Q3TQA9 Q9CVZ9 Q9Z151

Database IDs:

Citations:

PubMed ID: 10811014

Title: A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM).

PubMed ID: 10811014

DOI: 10.1002/jlb.67.5.725

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15811952

Title: The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM.

PubMed ID: 15811952

DOI: 10.1182/blood-2005-02-0817

PubMed ID: 15781451

Title: Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule.

PubMed ID: 15781451

DOI: 10.1074/jbc.m502095200

PubMed ID: 18329370

Title: Regulation of a late phase of T cell polarity and effector functions by Crtam.

PubMed ID: 18329370

DOI: 10.1016/j.cell.2008.01.013

PubMed ID: 19752223

Title: CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node.

PubMed ID: 19752223

DOI: 10.4049/jimmunol.0901248

PubMed ID: 24687959

Title: CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection.

PubMed ID: 24687959

DOI: 10.1084/jem.20130904

Sequence Information:

Length: 393
Mass: 43907
Checksum: 74666FFB7844D2B3
Sequence:

MWWGALSLLF WVPVQAAFLK METVTVEEGQ TLTLTCVTSQ TKNVSLQWLA PSGFTIFLNQ 
HPALKSSKYQ LLHHSATQLS ISVSNVTLRE EGVYTCLHYG SSVKTKQVRV TVLVTPFQPT 
VEALVLRRQN GEKSVVLKCS TERSKPPPQI TWLLGEGLEI YGELNHEFEA DGKICNTSSM 
LIARAYGKNS TVHCIIQHEG LHGRKLVAPF QFEDLVADQE TSDQETSDAP EQSSLSSQAL 
QQPTSTVSMM ENSSIPETDK EEKEHATQDP GLSTEASAQH TGLARRKSGI LLLTLVSFLI 
FILFIIVQLF IMKLRKAHVV WKKESEISEQ ALESYRSRSN NEETSSQENS SQAPQSKRCM 
NYITRLYSGA KTKKSAQHWK LGGKHSRVPE SIV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Crtam

Associated with

Other Information

A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM). PubMed ID: 10811014

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. PubMed ID: 15811952

Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. PubMed ID: 15781451

Regulation of a late phase of T cell polarity and effector functions by Crtam. PubMed ID: 18329370

CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node. PubMed ID: 19752223

CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection. PubMed ID: 24687959