Details for: KIF1A

Gene ID: 547

Symbol: KIF1A

Ensembl ID: ENSG00000130294

Description: kinesin family member 1A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 3.8420
    Cell Significance Index: 242.1500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.9541
    Cell Significance Index: 22.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.8937
    Cell Significance Index: 177.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.5973
    Cell Significance Index: 136.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0957
    Cell Significance Index: 420.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7961
    Cell Significance Index: 644.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8819
    Cell Significance Index: 609.9800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7590
    Cell Significance Index: 21.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6487
    Cell Significance Index: 39.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4437
    Cell Significance Index: 400.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.4166
    Cell Significance Index: 566.4200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4128
    Cell Significance Index: 5.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2781
    Cell Significance Index: 6.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2549
    Cell Significance Index: 17.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1323
    Cell Significance Index: 203.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0913
    Cell Significance Index: 9.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0861
    Cell Significance Index: 162.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0323
    Cell Significance Index: 5.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0225
    Cell Significance Index: 41.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0140
    Cell Significance Index: 2.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0012
    Cell Significance Index: 0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0035
    Cell Significance Index: -2.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0162
    Cell Significance Index: -0.5700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0581
    Cell Significance Index: -2.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0586
    Cell Significance Index: -11.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0691
    Cell Significance Index: -51.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0734
    Cell Significance Index: -10.6700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0746
    Cell Significance Index: -1.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0889
    Cell Significance Index: -50.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0890
    Cell Significance Index: -48.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0939
    Cell Significance Index: -68.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0976
    Cell Significance Index: -73.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1154
    Cell Significance Index: -51.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1265
    Cell Significance Index: -79.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1366
    Cell Significance Index: -62.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1899
    Cell Significance Index: -5.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2004
    Cell Significance Index: -7.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2132
    Cell Significance Index: -61.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2241
    Cell Significance Index: -3.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3106
    Cell Significance Index: -33.7900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3264
    Cell Significance Index: -5.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.3402
    Cell Significance Index: -67.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3465
    Cell Significance Index: -72.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.3550
    Cell Significance Index: -64.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3660
    Cell Significance Index: -20.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4955
    Cell Significance Index: -68.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5083
    Cell Significance Index: -65.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.5234
    Cell Significance Index: -64.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5590
    Cell Significance Index: -65.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5976
    Cell Significance Index: -68.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6044
    Cell Significance Index: -16.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6153
    Cell Significance Index: -27.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6155
    Cell Significance Index: -19.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6570
    Cell Significance Index: -68.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6574
    Cell Significance Index: -45.4700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7475
    Cell Significance Index: -18.6400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.7689
    Cell Significance Index: -8.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.8920
    Cell Significance Index: -53.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8964
    Cell Significance Index: -66.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9857
    Cell Significance Index: -75.6400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0436
    Cell Significance Index: -12.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0724
    Cell Significance Index: -22.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.1332
    Cell Significance Index: -24.5500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -1.1425
    Cell Significance Index: -17.0900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.1715
    Cell Significance Index: -23.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.2422
    Cell Significance Index: -64.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3216
    Cell Significance Index: -42.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3293
    Cell Significance Index: -33.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3349
    Cell Significance Index: -43.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.3698
    Cell Significance Index: -64.3800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.4538
    Cell Significance Index: -12.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.5083
    Cell Significance Index: -52.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.5238
    Cell Significance Index: -30.1300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -1.6153
    Cell Significance Index: -19.5800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.6165
    Cell Significance Index: -23.1500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.6167
    Cell Significance Index: -34.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.6405
    Cell Significance Index: -85.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.7028
    Cell Significance Index: -59.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.7030
    Cell Significance Index: -79.4000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.7224
    Cell Significance Index: -41.7200
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.7523
    Cell Significance Index: -16.6100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.7539
    Cell Significance Index: -21.8700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.7998
    Cell Significance Index: -56.9300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.8339
    Cell Significance Index: -19.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.8611
    Cell Significance Index: -47.8400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.8766
    Cell Significance Index: -46.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.9255
    Cell Significance Index: -50.6300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -2.0248
    Cell Significance Index: -35.0100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -2.0521
    Cell Significance Index: -42.8300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -2.2561
    Cell Significance Index: -28.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.2703
    Cell Significance Index: -66.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.2974
    Cell Significance Index: -61.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -2.3001
    Cell Significance Index: -65.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.3632
    Cell Significance Index: -50.3300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -2.3934
    Cell Significance Index: -39.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -2.4212
    Cell Significance Index: -50.2300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -2.4617
    Cell Significance Index: -27.8100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -2.4760
    Cell Significance Index: -32.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -2.4864
    Cell Significance Index: -52.0500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -2.4898
    Cell Significance Index: -16.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** KIF1A is a kinesin-like protein that exhibits plus-end-directed microtubule motor activity, meaning it moves along microtubules towards the plus end. This property allows KIF1A to facilitate anterograde and retrograde transport of cargo along microtubules. KIF1A has a high ATPase activity, which is essential for its motor function. The protein is also involved in regulating dendritic spine development and morphology, suggesting its role in synaptic plasticity and neuronal function. **Pathways and Functions** KIF1A is involved in various cellular pathways, including: 1. **Anterograde axonal transport**: KIF1A facilitates the transport of cargo from the cell body to the axon terminals, a process essential for neuronal communication and synaptic transmission. 2. **Retrograde neuronal dense core vesicle transport**: KIF1A regulates the transport of dense core vesicles, which contain neurotransmitters and other signaling molecules, from the axon terminals back to the cell body. 3. **Membrane trafficking**: KIF1A is involved in the transport of membrane-bound cargo, such as vesicles and organelles, within the cell. 4. **Cytoskeletal motor activity**: KIF1A interacts with microtubules and actin filaments to regulate cytoskeletal dynamics and cellular movement. 5. **Regulation of dendritic spine development**: KIF1A influences the development and morphology of dendritic spines, which are critical structures involved in synaptic plasticity and neuronal communication. **Clinical Significance** Dysregulation of KIF1A has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: Altered expression and function of KIF1A have been linked to neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Neurodevelopmental disorders**: KIF1A dysfunction has been associated with neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. 3. **Cancer**: KIF1A has been implicated in cancer progression and metastasis, particularly in the context of glioblastoma and other brain tumors. 4. **Hemostasis**: KIF1A plays a role in regulating platelet production and function, which is essential for maintaining hemostasis and preventing bleeding disorders. In conclusion, KIF1A is a critical protein involved in various cellular processes, including anterograde and retrograde axonal transport, neuronal dense core vesicle transport, and membrane trafficking. Dysregulation of KIF1A has been implicated in various neurological and cancer disorders, highlighting the importance of this protein in maintaining normal cellular function and preventing disease.

Genular Protein ID: 2608053695

Symbol: KIF1A_HUMAN

Name: Kinesin-like protein KIF1A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8661001

Title: Characterization of a kinesin-related gene ATSV, within the tuberous sclerosis locus (TSC1) candidate region on chromosome 9q34.

PubMed ID: 8661001

DOI: 10.1006/geno.1996.0217

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 21820098

Title: KIF1A, an axonal transporter of synaptic vesicles, is mutated in hereditary sensory and autonomic neuropathy type 2.

PubMed ID: 21820098

DOI: 10.1016/j.ajhg.2011.06.013

PubMed ID: 21376300

Title: Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability.

PubMed ID: 21376300

DOI: 10.1016/j.ajhg.2011.02.001

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 30021165

Title: Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-alpha/TANC2 Recruits DCVs to Postsynaptic Sites.

PubMed ID: 30021165

DOI: 10.1016/j.celrep.2018.06.071

PubMed ID: 25585697

Title: Dominant transmission of de novo KIF1A motor domain variant underlying pure spastic paraplegia.

PubMed ID: 25585697

DOI: 10.1038/ejhg.2014.297

PubMed ID: 26410750

Title: Variants in KIF1A gene in dominant and sporadic forms of hereditary spastic paraparesis.

PubMed ID: 26410750

DOI: 10.1007/s00415-015-7899-9

PubMed ID: 21487076

Title: Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis.

PubMed ID: 21487076

DOI: 10.1101/gr.117143.110

PubMed ID: 22258533

Title: KIF1A missense mutations in SPG30, an autosomal recessive spastic paraplegia: distinct phenotypes according to the nature of the mutations.

PubMed ID: 22258533

DOI: 10.1038/ejhg.2011.261

PubMed ID: 25253658

Title: KIF1A mutation in a patient with progressive neurodegeneration.

PubMed ID: 25253658

DOI: 10.1038/jhg.2014.80

PubMed ID: 26125038

Title: De novo mutations in KIF1A cause progressive encephalopathy and brain atrophy.

PubMed ID: 26125038

DOI: 10.1002/acn3.198

PubMed ID: 26354034

Title: De novo KIF1A mutations cause intellectual deficit, cerebellar atrophy, lower limb spasticity and visual disturbance.

PubMed ID: 26354034

DOI: 10.1038/jhg.2015.108

PubMed ID: 25265257

Title: De novo mutations in the motor domain of KIF1A cause cognitive impairment, spastic paraparesis, axonal neuropathy, and cerebellar atrophy.

PubMed ID: 25265257

DOI: 10.1002/humu.22709

PubMed ID: 26486474

Title: De novo dominant variants affecting the motor domain of KIF1A are a cause of PEHO syndrome.

PubMed ID: 26486474

DOI: 10.1038/ejhg.2015.217

PubMed ID: 27034427

Title: Novel De Novo Mutations in KIF1A as a Cause of Hereditary Spastic Paraplegia With Progressive Central Nervous System Involvement.

PubMed ID: 27034427

DOI: 10.1177/0883073816639718

PubMed ID: 29159194

Title: Multigeneration family with dominant SPG30 hereditary spastic paraplegia.

PubMed ID: 29159194

DOI: 10.1002/acn3.452

PubMed ID: 28832565

Title: Massive sequencing of 70 genes reveals a myriad of missing genes or mechanisms to be uncovered in hereditary spastic paraplegias.

PubMed ID: 28832565

DOI: 10.1038/ejhg.2017.124

PubMed ID: 28834584

Title: A de novo dominant mutation in KIF1A associated with axonal neuropathy, spasticity and autism spectrum disorder.

PubMed ID: 28834584

DOI: 10.1111/jns.12235

PubMed ID: 29934652

Title: Targeted next-generation sequencing improves diagnosis of hereditary spastic paraplegia in Chinese patients.

PubMed ID: 29934652

DOI: 10.1007/s00109-018-1655-4

PubMed ID: 31796088

Title: Long-term follow-up until early adulthood in autosomal dominant, complex SPG30 with a novel KIF1A variant: a case report.

PubMed ID: 31796088

DOI: 10.1186/s13052-019-0752-5

PubMed ID: 31488895

Title: KIF1A variants are a frequent cause of autosomal dominant hereditary spastic paraplegia.

PubMed ID: 31488895

DOI: 10.1038/s41431-019-0497-z

PubMed ID: 32652677

Title: Expansion of the phenotypic spectrum of de novo missense variants in kinesin family member 1A (KIF1A).

PubMed ID: 32652677

DOI: 10.1002/humu.24079

PubMed ID: 32096284

Title: KIF1A-related disorders in children: A wide spectrum of central and peripheral nervous system involvement.

PubMed ID: 32096284

DOI: 10.1111/jns.12368

PubMed ID: 31805580

Title: Mobility characteristics of children with spastic paraplegia due to a mutation in the KIF1A gene.

PubMed ID: 31805580

DOI: 10.1055/s-0039-3400988

PubMed ID: 33880452

Title: Genotype and defects in microtubule-based motility correlate with clinical severity in KIF1A-associated neurological disorder.

PubMed ID: 33880452

DOI: 10.1016/j.xhgg.2021.100026

Sequence Information:

  • Length: 1690
  • Mass: 191064
  • Checksum: FB3CA33B7060AF60
  • Sequence:
  • MAGASVKVAV RVRPFNSREM SRDSKCIIQM SGSTTTIVNP KQPKETPKSF SFDYSYWSHT 
    SPEDINYASQ KQVYRDIGEE MLQHAFEGYN VCIFAYGQTG AGKSYTMMGK QEKDQQGIIP 
    QLCEDLFSRI NDTTNDNMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 
    LSKLAVTSYN DIQDLMDSGN KARTVAATNM NETSSRSHAV FNIIFTQKRH DAETNITTEK 
    VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEMDS GPNKNKKKKK 
    TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIRCNAVI 
    NEDPNNKLIR ELKDEVTRLR DLLYAQGLGD ITDMTNALVG MSPSSSLSAL SSRAASVSSL 
    HERILFAPGS EEAIERLKET EKIIAELNET WEEKLRRTEA IRMEREALLA EMGVAMREDG 
    GTLGVFSPKK TPHLVNLNED PLMSECLLYY IKDGITRVGR EDGERRQDIV LSGHFIKEEH 
    CVFRSDSRGG SEAVVTLEPC EGADTYVNGK KVTEPSILRS GNRIIMGKSH VFRFNHPEQA 
    RQERERTPCA ETPAEPVDWA FAQRELLEKQ GIDMKQEMEQ RLQELEDQYR REREEATYLL 
    EQQRLDYESK LEALQKQMDS RYYPEVNEEE EEPEDEVQWT ERECELALWA FRKWKWYQFT 
    SLRDLLWGNA IFLKEANAIS VELKKKVQFQ FVLLTDTLYS PLPPDLLPPE AAKDRETRPF 
    PRTIVAVEVQ DQKNGATHYW TLEKLRQRLD LMREMYDRAA EVPSSVIEDC DNVVTGGDPF 
    YDRFPWFRLV GRAFVYLSNL LYPVPLVHRV AIVSEKGEVK GFLRVAVQAI SADEEAPDYG 
    SGVRQSGTAK ISFDDQHFEK FQSESCPVVG MSRSGTSQEE LRIVEGQGQG ADVGPSADEV 
    NNNTCSAVPP EGLLLDSSEK AALDGPLDAA LDHLRLGNTF TFRVTVLQAS SISAEYADIF 
    CQFNFIHRHD EAFSTEPLKN TGRGPPLGFY HVQNIAVEVT KSFIEYIKSQ PIVFEVFGHY 
    QQHPFPPLCK DVLSPLRPSR RHFPRVMPLS KPVPATKLST LTRPCPGPCH CKYDLLVYFE 
    ICELEANGDY IPAVVDHRGG MPCMGTFLLH QGIQRRITVT LLHETGSHIR WKEVRELVVG 
    RIRNTPETDE SLIDPNILSL NILSSGYIHP AQDDRTFYQF EAAWDSSMHN SLLLNRVTPY 
    REKIYMTLSA YIEMENCTQP AVVTKDFCMV FYSRDAKLPA SRSIRNLFGS GSLRASESNR 
    VTGVYELSLC HVADAGSPGM QRRRRRVLDT SVAYVRGEEN LAGWRPRSDS LILDHQWELE 
    KLSLLQEVEK TRHYLLLREK LETAQRPVPE ALSPAFSEDS ESHGSSSASS PLSAEGRPSP 
    LEAPNERQRE LAVKCLRLLT HTFNREYTHS HVCVSASESK LSEMSVTLLR DPSMSPLGVA 
    TLTPSSTCPS LVEGRYGATD LRTPQPCSRP ASPEPELLPE ADSKKLPSPA RATETDKEPQ 
    RLLVPDIQEI RVSPIVSKKG YLHFLEPHTS GWARRFVVVR RPYAYMYNSD KDTVERFVLN 
    LATAQVEYSE DQQAMLKTPN TFAVCTEHRG ILLQAASDKD MHDWLYAFNP LLAGTIRSKL 
    SRRRSAQMRV

Genular Protein ID: 1111105731

Symbol: A0A3B3ITE5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 1724
  • Mass: 194556
  • Checksum: 038AE5CE2C4B2BFE
  • Sequence:
  • MAGASVKVAV RVRPFNSREM SRDSKCIIQM SGSTTTIVNP KQPKETPKSF SFDYSYWSHT 
    SPEDINYASQ KQVYRDIGEE MLQHAFEGYN VCIFAYGQTG AGKSYTMMGK QEKDQQGIIP 
    QLCEDLFSRI NDTTNDNMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 
    LSKLAVTSYN DIQDLMDSGN KARTVAATNM NETSSRSHAV FNIIFTQKRH DAETNITTEK 
    VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEMDS GPNKNKKKKK 
    TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIRCNAVI 
    NEDPNNKLIR ELKDEVTRLR DLLYAQGLGD ITDTNTVPGG PKYVSDLENN NLNRGGTVNE 
    APDPLSTVTN ALVGMSPSSS LSALSSRAAS VSSLHERILF APGSEEAIER LKETEKIIAE 
    LNETWEEKLR RTEAIRMERE ALLAEMGVAM REDGGTLGVF SPKKTPHLVN LNEDPLMSEC 
    LLYYIKDGIT RVGREDGERR QDIVLSGHFI KEEHCVFRSD SRGGSEAVVT LEPCEGADTY 
    VNGKKVTEPS ILRSGNRIIM GKSHVFRFNH PEQARQERER TPCAETPAEP VDWAFAQREL 
    LEKQGIDMKQ EMEQRLQELE DQYRREREEA TYLLEQQRLD YESKLEALQK QMDSRYYPEV 
    NEEEEEPEDE VQWTERECEL ALWAFRKWKW YQFTSLRDLL WGNAIFLKEA NAISVELKKK 
    VQFQFVLLTD TLYSPLPPDL LPPEAAKDRE TRPFPRTIVA VEVQDQKNGA THYWTLEKLR 
    QRLDLMREMY DRAAEVPSSV IEDCDNVVTG GDPFYDRFPW FRLVGRAFVY LSNLLYPVPL 
    VHRVAIVSEK GEVKGFLRVA VQAISADEEA PDYGSGVRQS GTAKISFDDQ HFEKFQSESC 
    PVVGMSRSGT SQEELRIVEG QGQGADVGPS ADEVNNNTCS AVPPEGLLLD SSEKAALDGP 
    LDAALDHLRL GNTFTFRVTV LQASSISAEY ADIFCQFNFI HRHDEAFSTE PLKNTGRGPP 
    LGFYHVQNIA VEVTKSFIEY IKSQPIVFEV FGHYQQHPFP PLCKDVLSPL RPSRRHFPRV 
    MPLSKPVPAT KLSTLTRPCP GPCHCKYDLL VYFEICELEA NGDYIPAVVD HRGGMPCMGT 
    FLLHQGIQRR ITVTLLHETG SHIRWKEVRE LVVGRIRNTP ETDESLIDPN ILSLNILSSG 
    YIHPAQDDRT FYQFEAAWDS SMHNSLLLNR VTPYREKIYM TLSAYIEMEN CTQPAVVTKD 
    FCMVFYSRDA KLPASRSIRN LFGSGSLRAS ESNRVTGVYE LSLCHVADAG SPGMQRRRRR 
    VLDTSVAYVR GEENLAGWRP RSDSLILDHQ WELEKLSLLQ EVEKTRHYLL LREKLETAQR 
    PVPEALSPAF SEDSESHGSS SASSPLSAEG RPSPLEAPNE RQRELAVKCL RLLTHTFNRE 
    YTHSHVCVSA SESKLSEMSV TLLRDPSMSP LGVATLTPSS TCPSLVEGRY GATDLRTPQP 
    CSRPASPEPE LLPEADSKKL PSPARATETD KEPQRLLVPD IQEIRVSPIV SKKGYLHFLE 
    PHTSGWARRF VVVRRPYAYM YNSDKDTVER FVLNLATAQV EYSEDQQAML KTPNTFAVCT 
    EHRGILLQAA SDKDMHDWLY AFNPLLAGTI RSKLSRRRSA QMRV

Genular Protein ID: 432755203

Symbol: A0A3B3IT28_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 1708
  • Mass: 192970
  • Checksum: 1704D8FC2783AD21
  • Sequence:
  • MAGASVKVAV RVRPFNSREM SRDSKCIIQM SGSTTTIVNP KQPKETPKSF SFDYSYWSHT 
    SPEDINYASQ KQVYRDIGEE MLQHAFEGYN VCIFAYGQTG AGKSYTMMGK QEKDQQGIIP 
    QLCEDLFSRI NDTTNDNMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 
    LSKLAVTSYN DIQDLMDSGN KARTVAATNM NETSSRSHAV FNIIFTQKRH DAETNITTEK 
    VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEMDS GPNKNKKKKK 
    TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIRCNAVI 
    NEDPNNKLIR ELKDEVTRLR DLLYAQGLGD ITDTNTVPGG PKLTNALVGM SPSSSLSALS 
    SRAASVSSLH ERILFAPGSE EAIERLKETE KIIAELNETW EEKLRRTEAI RMEREALLAE 
    MGVAMREDGG TLGVFSPKKT PHLVNLNEDP LMSECLLYYI KDGITRVGRE DGERRQDIVL 
    SGHFIKEEHC VFRSDSRGGS EAVVTLEPCE GADTYVNGKK VTEPSILRSG NRIIMGKSHV 
    FRFNHPEQAR QERERTPCAE TPAEPVDWAF AQRELLEKQG IDMKQEMEQR LQELEDQYRR 
    EREEATYLLE QQRLDYESKL EALQKQMDSR YYPEVNEEEE EPEDEVQWTE RECELALWAF 
    RKWKWYQFTS LRDLLWGNAI FLKEANAISV ELKKKVQFQF VLLTDTLYSP LPPDLLPPEA 
    AKDRETRPFP RTIVAVEVQD QKNGATHYWT LEKLRQRLDL MREMYDRAAE VPSSVIEDCD 
    NVVTGGDPFY DRFPWFRLVG RAFVYLSNLL YPVPLVHRVA IVSEKGEVKG FLRVAVQAIS 
    ADEEAPDYGS GVRQSGTAKI SFDDQHFEKF QSESCPVVGM SRSGTSQEEL RIVEGQGQGA 
    DVGPSADEVN NNTCSAVPPE GLLLDSSEKA ALDGPLDAAL DHLRLGNTFT FRVTVLQASS 
    ISAEYADIFC QFNFIHRHDE AFSTEPLKNT GRGPPLGFYH VQNIAVEVTK SFIEYIKSQP 
    IVFEVFGHYQ QHPFPPLCKD VLSPLRPSRR HFPRVMPLSK PVPATKLSTL TRPCPGPCHC 
    KYDLLVYFEI CELEANGDYI PAVVDHRGGM PCMGTFLLHQ GIQRRITVTL LHETGSHIRW 
    KEVRELVVGR IRNTPETDES LIDPNILSLN ILSSGYIHPA QDDRQFLDSD IPRTFYQFEA 
    AWDSSMHNSL LLNRVTPYRE KIYMTLSAYI EMENCTQPAV VTKDFCMVFY SRDAKLPASR 
    SIRNLFGSGS LRASESNRVT GVYELSLCHV ADAGSPGMQR RRRRVLDTSV AYVRGEENLA 
    GWRPRSDSLI LDHQWELEKL SLLQEVEKTR HYLLLREKLE TAQRPVPEAL SPAFSEDSES 
    HGSSSASSPL SAEGRPSPLE APNERQRELA VKCLRLLTHT FNREYTHSHV CVSASESKLS 
    EMSVTLLRDP SMSPLGVATL TPSSTCPSLV EGRYGATDLR TPQPCSRPAS PEPELLPEAD 
    SKKLPSPARA TETDKEPQRL LVPDIQEIRV SPIVSKKGYL HFLEPHTSGW ARRFVVVRRP 
    YAYMYNSDKD TVERFVLNLA TAQVEYSEDQ QAMLKTPNTF AVCTEHRGIL LQAASDKDMH 
    DWLYAFNPLL AGTIRSKLSR RRSAQMRV

Genular Protein ID: 2508115858

Symbol: A0A3B3IU40_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 1699
  • Mass: 191898
  • Checksum: D1FE33C15470BDA8
  • Sequence:
  • MAGASVKVAV RVRPFNSREM SRDSKCIIQM SGSTTTIVNP KQPKETPKSF SFDYSYWSHT 
    SPEDINYASQ KQVYRDIGEE MLQHAFEGYN VCIFAYGQTG AGKSYTMMGK QEKDQQGIIP 
    QLCEDLFSRI NDTTNDNMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 
    LSKLAVTSYN DIQDLMDSGN KARTVAATNM NETSSRSHAV FNIIFTQKRH DAETNITTEK 
    VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEMDS GPNKNKKKKK 
    TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIRCNAVI 
    NEDPNNKLIR ELKDEVTRLR DLLYAQGLGD ITDTNTVPGG PKLTNALVGM SPSSSLSALS 
    SRAASVSSLH ERILFAPGSE EAIERLKETE KIIAELNETW EEKLRRTEAI RMEREALLAE 
    MGVAMREDGG TLGVFSPKKT PHLVNLNEDP LMSECLLYYI KDGITRVGRE DGERRQDIVL 
    SGHFIKEEHC VFRSDSRGGS EAVVTLEPCE GADTYVNGKK VTEPSILRSG NRIIMGKSHV 
    FRFNHPEQAR QERERTPCAE TPAEPVDWAF AQRELLEKQG IDMKQEMEQR LQELEDQYRR 
    EREEATYLLE QQRLDYESKL EALQKQMDSR YYPEVNEEEE EPEDEVQWTE RECELALWAF 
    RKWKWYQFTS LRDLLWGNAI FLKEANAISV ELKKKVQFQF VLLTDTLYSP LPPDLLPPEA 
    AKDRETRPFP RTIVAVEVQD QKNGATHYWT LEKLRQRLDL MREMYDRAAE VPSSVIEDCD 
    NVVTGGDPFY DRFPWFRLVG RAFVYLSNLL YPVPLVHRVA IVSEKGEVKG FLRVAVQAIS 
    ADEEAPDYGS GVRQSGTAKI SFDDQHFEKF QSESCPVVGM SRSGTSQEEL RIVEGQGQGA 
    DVGPSADEVN NNTCSAVPPE GLLLDSSEKA ALDGPLDAAL DHLRLGNTFT FRVTVLQASS 
    ISAEYADIFC QFNFIHRHDE AFSTEPLKNT GRGPPLGFYH VQNIAVEVTK SFIEYIKSQP 
    IVFEVFGHYQ QHPFPPLCKD VLSPLRPSRR HFPRVMPLSK PVPATKLSTL TRPCPGPCHC 
    KYDLLVYFEI CELEANGDYI PAVVDHRGGM PCMGTFLLHQ GIQRRITVTL LHETGSHIRW 
    KEVRELVVGR IRNTPETDES LIDPNILSLN ILSSGYIHPA QDDRTFYQFE AAWDSSMHNS 
    LLLNRVTPYR EKIYMTLSAY IEMENCTQPA VVTKDFCMVF YSRDAKLPAS RSIRNLFGSG 
    SLRASESNRV TGVYELSLCH VADAGSPGMQ RRRRRVLDTS VAYVRGEENL AGWRPRSDSL 
    ILDHQWELEK LSLLQEVEKT RHYLLLREKL ETAQRPVPEA LSPAFSEDSE SHGSSSASSP 
    LSAEGRPSPL EAPNERQREL AVKCLRLLTH TFNREYTHSH VCVSASESKL SEMSVTLLRD 
    PSMSPLGVAT LTPSSTCPSL VEGRYGATDL RTPQPCSRPA SPEPELLPEA DSKKLPSPAR 
    ATETDKEPQR LLVPDIQEIR VSPIVSKKGY LHFLEPHTSG WARRFVVVRR PYAYMYNSDK 
    DTVERFVLNL ATAQVEYSED QQAMLKTPNT FAVCTEHRGI LLQAASDKDM HDWLYAFNPL 
    LAGTIRSKLS RRRSAQMRV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.