SLC6A20 | ENSG00000163817 | NCBI 54716

Details for: SLC6A20

Gene ID: 54716

Symbol: SLC6A20

Ensembl ID: ENSG00000163817

Description: solute carrier family 6 member 20

Associated with

Amino acid transport across the plasma membrane
(R-HSA-352230)
Disease
(R-HSA-1643685)
Disorders of transmembrane transporters
(R-HSA-5619115)
Na+/cl- dependent neurotransmitter transporters
(R-HSA-442660)
Slc-mediated transmembrane transport
(R-HSA-425407)
Slc transporter disorders
(R-HSA-5619102)
Transport of bile salts and organic acids, metal ions and amine compounds
(R-HSA-425366)
Transport of inorganic cations/anions and amino acids/oligopeptides
(R-HSA-425393)
Transport of small molecules
(R-HSA-382551)
Variant slc6a20 contributes towards hyperglycinuria (hg) and iminoglycinuria (ig)
(R-HSA-5660686)
Amino-acid betaine transmembrane transporter activity
(GO:0015199)
Amino-acid betaine transport
(GO:0015838)
Amino acid import across plasma membrane
(GO:0089718)
Amino acid transmembrane transporter activity
(GO:0015171)
Amino acid transport
(GO:0006865)
Apical plasma membrane
(GO:0016324)
Glycine import across plasma membrane
(GO:1903804)
Glycine transport
(GO:0015816)
L-isoleucine import across plasma membrane
(GO:1903806)
L-isoleucine transmembrane transporter activity
(GO:0015188)
L-proline import across plasma membrane
(GO:1904271)
L-proline transmembrane transporter activity
(GO:0015193)
Neutral l-amino acid transmembrane transporter activity
(GO:0015175)
Plasma membrane
(GO:0005886)
Proline:sodium symporter activity
(GO:0005298)
Proline import across plasma membrane
(GO:1905647)
Proline transport
(GO:0015824)
Protein binding
(GO:0005515)
Sodium ion transmembrane transport
(GO:0035725)
Solute:sodium symporter activity
(GO:0015370)
Transport across blood-brain barrier
(GO:0150104)

Other Information

Proteins

Solute carrier family 6 member 20

Genular Protein ID: 3234154233

Symbol: S6A20_HUMAN

Name: Solute carrier family 6 member 20

UniProtKB Accession Codes:

Q9NP91 A1A4F2 O75590 Q8TF10 Q9NPQ2 Q9NQ77

Database IDs:

Citations:

PubMed ID: 11352561

Title: The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3.

PubMed ID: 11352561

DOI: 10.1006/geno.2000.6498

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9932288

Title: Cloning, gene structure, and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms.

PubMed ID: 9932288

PubMed ID: 15632147

Title: Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino.

PubMed ID: 15632147

DOI: 10.1074/jbc.m413027200

PubMed ID: 33428810

Title: SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function.

PubMed ID: 33428810

DOI: 10.15252/emmm.202012632

PubMed ID: 19033659

Title: Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters.

PubMed ID: 19033659

DOI: 10.1172/jci36625

Sequence Information:

Length: 592
Mass: 65914
Checksum: AF6E94E19895377F
Sequence:

MEKARPLWAN SLQFVFACIS YAVGLGNVWR FPYLCQMYGG GSFLVPYIIM LIVEGMPLLY 
LELAVGQRMR QGSIGAWRTI SPYLSGVGVA SVVVSFFLSM YYNVINAWAF WYLFHSFQDP 
LPWSVCPLNG NHTGYDEECE KASSTQYFWY RKTLNISPSL QENGGVQWEP ALCLLLAWLV 
VYLCILRGTE STGKVVYFTA SLPYCVLIIY LIRGLTLHGA TNGLMYMFTP KIEQLANPKA 
WINAATQIFF SLGLGFGSLI AFASYNEPSN NCQKHAIIVS LINSFTSIFA SIVTFSIYGF 
KATFNYENCL KKVSLLLTNT FDLEDGFLTA SNLEQVKGYL ASAYPSKYSE MFPQIKNCSL 
ESELDTAVQG TGLAFIVYTE AIKNMEVSQL WSVLYFFMLL MLGIGSMLGN TAAILTPLTD 
SKIISSHLPK EAISGLVCLV NCAIGMVFTM EAGNYWFDIF NDYAATLSLL LIVLVETIAV 
CYVYGLRRFE SDLKAMTGRA VSWYWKVMWA GVSPLLIVSL FVFYLSDYIL TGTLKYQAWD 
ASQGQLVTKD YPAYALAVIG LLVASSTMCI PLAALGTFVQ RRLKRGDADP VA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SLC6A20

Associated with

Other Information

The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3. PubMed ID: 11352561

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning, gene structure, and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms. PubMed ID: 9932288

Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino. PubMed ID: 15632147

SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function. PubMed ID: 33428810