Details for: Tyk2

Gene ID: 54721

Symbol: Tyk2

Ensembl ID: ENSMUSG00000032175

Description: tyrosine kinase 2

Associated with

Other Information

Genular Protein ID: 3352227101

Symbol: TYK2_MOUSE

Name: Non-receptor tyrosine-protein kinase TYK2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11070173

Title: Partial impairment of cytokine responses in Tyk2-deficient mice.

PubMed ID: 11070173

DOI: 10.1016/s1074-7613(00)00054-6

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11070174

Title: Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function.

PubMed ID: 11070174

DOI: 10.1016/s1074-7613(00)00055-8

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22859374

Title: Docking protein Gab2 regulates mucin expression and goblet cell hyperplasia through TYK2/STAT6 pathway.

PubMed ID: 22859374

DOI: 10.1096/fj.12-211755

PubMed ID: 22995073

Title: Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor.

PubMed ID: 22995073

DOI: 10.1186/1472-6807-12-22

Sequence Information:

  • Length: 1184
  • Mass: 133315
  • Checksum: 2B42052073463AC8
  • Sequence:
  • MVGTMPLCGR RAILEDSKAD GTEAQPLVPT GCLMVLLHWP GPEGGEPWVT FSQTSLTAEE 
    VCIHIAHKVG ITPPCLNLFA LYNAQAKVWL PPNHILDTSQ DMNLYFRMRF YFRNWHGMNP 
    QEPAVYRCGF PGAETSSDRA EQGVQLLDSA SFEYLFEQGK HEFMNDVVSL RDLSSEEEIH 
    HFKNESLGMA FLHLCHLALS RGVPLEEMAR EISFKNCIPH SFRQHIRQHN VLTRLRLHRV 
    FRRFLRAFRP GHLSQQVVMV KYLATLERLA PRFGSERIPV CHLEVLAQPE RDPCYIQNSG 
    QTAGDPGPEL PSGPPTHEVL VTGTGGIQWH PLQTQESERG NSRGNPHGSR SGKKPKAPKA 
    GEHLTESPQE PPWTYFCDFQ DISHVVLKER RVHIHLQDNK CLLLCLCSQA EALSFVALVD 
    GYFRLTADSS HYLCHEVAPP RLVTSIQNGI HGPLMDPFVQ AKLWPEDGLY LIQWSTSHLH 
    RLILTVAHRN PAFSNGPRGL RLRKFPITQQ PGAFVLDGWG RSFASLGDLR LALQGCSLRA 
    GDDCFPLHHC CLPRPREISN LVIMRGSRAH TRPLNLSQLS FHRVHQDEIT QLSHLGQGTR 
    TNVYEGLLRV GGPDEGKVDN GCPPEPGGTS GQQLRVVLKV LDPSHHDIAL AFYETASLMS 
    QVSHMHLAFL HGVCVRGSEN IIVTEFVEHG PLDVWLRRQR GQVPMTWKMV VAQQLASALS 
    YLEDKNLVHG NVCGRNILLA RLGLEEGTNP FIKLSDPGVG QGALSREERV ERIPWTAPEC 
    LSGGTSSLGT ATDMWGFGAT LLEICFDGEA PLQGRGPSEK ERFYTKKHQL PEPSSPELAT 
    LTRQCLTYEP AQRPSFRTIL RDLTRLQPQN LVGTSAVNSD SPASDPTVFH KRYLKKIRDL 
    GEGHFGKVSL YCYDPTNDGT GEMVAVKALK EGCGPQLRSG WQREIEILRT LYHEHIVKYK 
    GCCEDQGEKS VQLVMEYVPL GSLRDYLPRH CVGLAQLLLF AQQICEGMAY LHAQHYIHRD 
    LAARNVLLDN DRLVKIGDFG LAKAVPEGHE YYRVREDGDS PVFWYAPECL KECKFYYASD 
    VWSFGVTLYE LLTYCDSNQS PHMKFTELIG HTQGQMTVLR LTELLERGER LPRPDRCPCE 
    IYHLMKNCWE TEASFRPTFQ NLVPILQTAQ EKYQGQVPSV FSVC

Genular Protein ID: 2812324451

Symbol: E9QJS1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 1207
  • Mass: 135901
  • Checksum: 7207FF710AC80CE1
  • Sequence:
  • MVGTMPLCGR RAILEDSKAD GTEAQPLVPT GCLMVLLHWP GPEGGEPWVT FSQTSLTAEE 
    VCIHIAHKVG ITPPCLNLFA LYNAQAKVWL PPNHILDTSQ DMNLYFRMRF YFRNWHGMNP 
    QEPAVYRCGF PGAETSSDRA EQGVQLLDSA SFEYLFEQGW YVGNRAKSSH TSFSIHRSTP 
    QGKHEFMNDV VSLRDLSSEE EIHHFKNESL GMAFLHLCHL ALSRGVPLEE MAREISFKNC 
    IPHSFRQHIR QHNVLTRLRL HRVFRRFLRA FRPGHLSQQV VMVKYLATLE RLAPRFGSER 
    IPVCHLEVLA QPERDPCYIQ NSGQTAGDPG PELPSGPPTH EVLVTGTGGI QWHPLQTQES 
    ERGNSRGNPH GSRSGKKPKA PKAGEHLTES PQEPPWTYFC DFQDISHVVL KERRVHIHLQ 
    DNKCLLLCLC SQAEALSFVA LVDGYFRLTA DSSHYLCHEV APPRLVTSIQ NGIHGPLMDP 
    FVQAKLWPED GLYLIQWSTS HLHRLILTVA HRNPAFSNGP RGLRLRKFPI TQQPGAFVLD 
    GWGRSFASLG DLRLALQGCS LRAGDDCFPL HHCCLPRPRE ISNLVIMRGS RAHTRPLNLS 
    QLSFHRVHQD EITQLSHLGQ GTRTNVYEGL LRVGGPDEGK VDNGCPPEPG GTSGQQLRVV 
    LKVLDPSHHD IALAFYETAS LMSQVSHMHL AFLHGVCVRG SENIIVTEFV EHGPLDVWLR 
    RQRGQVPMTW KMVVAQQLAS ALSYLEDKNL VHGNVCGRNI LLARLGLEEG TNPFIKLSDP 
    GVGQGALSRE ERVERIPWTA PECLSGGTSS LGTATDMWGF GATLLEICFD GEAPLQGRGP 
    SEKERFYTKK HQLPEPSSPE LATLTRQCLT YEPAQRPSFR TILRDLTRLQ PQNLVGTSAV 
    NSDSPASDPT VFHKRYLKKI RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK ALKEGCGPQL 
    RSGWQREIEI LRTLYHEHIV KYKGCCEDQG EKSVQLVMEY VPLGSLRDYL PRHCVGLAQL 
    LLFAQQICEG MAYLHAQHYI HRDLAARNVL LDNDRLVKIG DFGLAKAVPE GHEYYRVRED 
    GDSPVFWYAP ECLKECKFYY ASDVWSFGVT LYELLTYCDS NQSPHMKFTE LIGHTQGQMT 
    VLRLTELLER GERLPRPDRC PCEIYHLMKN CWETEASFRP TFQNLVPILQ TAQEKYQGQV 
    PSVFSVC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.