Gsdme | ENSMUSG00000029821 | NCBI 54722

Details for: Gsdme

Gene ID: 54722

Symbol: Gsdme

Ensembl ID: ENSMUSG00000029821

Description: gasdermin E

Associated with

Apoptosis
(R-MMU-109581)
Apoptotic factor-mediated response
(R-MMU-111471)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Intrinsic pathway for apoptosis
(R-MMU-109606)
Regulated necrosis
(R-MMU-5218859)
Regulation of tlr by endogenous ligand
(R-MMU-5686938)
Release of apoptotic factors from the mitochondria
(R-MMU-111457)
Toll-like receptor cascades
(R-MMU-168898)
Cardiolipin binding
(GO:1901612)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular response to virus
(GO:0098586)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Granzyme-mediated programmed cell death signaling pathway
(GO:0140507)
Inner ear auditory receptor cell differentiation
(GO:0042491)
Membrane
(GO:0016020)
Negative regulation of cell population proliferation
(GO:0008285)
Phosphatidylinositol-4,5-bisphosphate binding
(GO:0005546)
Plasma membrane
(GO:0005886)
Positive regulation of immune response to tumor cell
(GO:0002839)
Positive regulation of intrinsic apoptotic signaling pathway
(GO:2001244)
Positive regulation of mapk cascade
(GO:0043410)
Programmed cell death
(GO:0012501)
Pyroptosis
(GO:0070269)
Sensory perception of sound
(GO:0007605)
Wide pore channel activity
(GO:0022829)

Other Information

Proteins

GSDME_MOUSE

Genular Protein ID: 184656232

Symbol: GSDME_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9Z2D3

Database IDs:

Citations:

PubMed ID: 9771715

Title: Nonsyndromic hearing impairment is associated with a mutation in DFNA5.

PubMed ID: 9771715

DOI: 10.1038/2503

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 28459430

Title: Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.

PubMed ID: 28459430

DOI: 10.1038/nature22393

PubMed ID: 28045099

Title: Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death.

PubMed ID: 28045099

DOI: 10.1038/ncomms14128

PubMed ID: 32188940

Title: Gasdermin E suppresses tumour growth by activating anti-tumour immunity.

PubMed ID: 32188940

DOI: 10.1038/s41586-020-2071-9

PubMed ID: 33852854

Title: Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases.

PubMed ID: 33852854

DOI: 10.1016/j.celrep.2021.108998

Sequence Information:

Length: 512
Mass: 56631
Checksum: 13AFB8627773C4A5
Sequence:

MFAKATRNFL KEVDAGGDLI SVSHLNDSDK LQLLSLVTKK KRYWCWQRPK YQILSATLED 
VLTEGHCLSP VVVESDFVKY ESKCENHKSG AIGTVVGKVK LNVGGKGVVE SHSSFGTLRK 
QEVDVQQLIQ DAVKRTVNMD NLVLQQVLES RNEVLCVLTQ KIMTTQKCVI SEHVQSEETC 
GGMVGIQTKT IQVSATEDGT VTTDTNVVLE IPAATTIAYG IMELFVKQDG QFEFCLLQGK 
HGGFEHERKL DSVYLDPLAY REFAFLDMLD GGQGISSQDG PLRVVKQATL HLERSFHPFA 
VLPAQQQRAL FCVLQKILFD EELLRALEQV CDDVAGGLWS SQAVLAMEEL TDSQQQDLTA 
FLQLVGYRIQ GEHPGPQDEV SNQKLFATAY FLVSALAEMP DNATVFLGTC CKLHVISSLC 
CLLHALSDDS VCDFHNPTLA PLRDTERFGI VQRLFASADI ALERMQFSAK ATILKDSCIF 
PLILHITLSG LSTLSKEHEE ELCQSGHATG QD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gsdme

Associated with

Other Information

Nonsyndromic hearing impairment is associated with a mutation in DFNA5. PubMed ID: 9771715

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. PubMed ID: 28459430

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. PubMed ID: 28045099

Gasdermin E suppresses tumour growth by activating anti-tumour immunity. PubMed ID: 32188940

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases. PubMed ID: 33852854