Details for: XAF1

Gene ID: 54739

Symbol: XAF1

Ensembl ID: ENSG00000132530

Description: XIAP associated factor 1

Associated with

Other Information

Genular Protein ID: 3603024598

Symbol: XAF1_HUMAN

Name: XIAP-associated factor 1

UniProtKB Accession Codes:

Q6GPH4 A2T931 A2T932 A8K2L1 A8K9Y3 D3DTM6 Q6MZE8 Q8N557 Q99982

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 4 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11175744

Title: Identification of XAF1 as an antagonist of XIAP anti-Caspase activity.

PubMed ID: 11175744

DOI: 10.1038/35055027

PubMed ID: 17570219

Title: Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses.

PubMed ID: 17570219

DOI: 10.1053/j.gastro.2007.04.024

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12029096

Title: Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis.

PubMed ID: 12029096

DOI: 10.1074/jbc.m204851200

PubMed ID: 16343440

Title: Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1.

PubMed ID: 16343440

DOI: 10.1016/j.bbrc.2005.11.128

PubMed ID: 16432762

Title: Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP.

PubMed ID: 16432762

DOI: 10.1007/s11010-005-9094-2

PubMed ID: 17613533

Title: Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex.

PubMed ID: 17613533

DOI: 10.1074/jbc.m700776200

PubMed ID: 17329253

Title: XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway.

PubMed ID: 17329253

DOI: 10.1074/jbc.m609038200

PubMed ID: 23645206

Title: ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).

PubMed ID: 23645206

DOI: 10.1038/cdd.2013.33

Sequence Information:

  • Length: 301
  • Mass: 34626
  • Checksum: FC9D48BD07BE541D
  • Sequence:
    • MEGDFSVCRN CKRHVVSANF TLHEAYCLRF LVLCPECEEP VPKETMEEHC KLEHQQVGCT 
MCQQSMQKSS LEFHKANECQ ERPVECKFCK LDMQLSKLEL HESYCGSRTE LCQGCGQFIM 
HRMLAQHRDV CRSEQAQLGK GERISAPERE IYCHYCNQMI PENKYFHHMG KCCPDSEFKK 
HFPVGNPEIL PSSLPSQAAE NQTSTMEKDV RPKTRSINRF PLHSESSSKK APRSKNKTLD 
PLLMSEPKPR TSSPRGDKAA YDILRRCSQC GILLPLPILN QHQEKCRWLA SSKGKQVRNF 
S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.