RNF111 | ENSG00000157450 | NCBI 54778

Details for: RNF111

Gene ID: 54778

Symbol: RNF111

Ensembl ID: ENSG00000157450

Description: ring finger protein 111

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Dna repair
(R-HSA-73894)
Downregulation of smad2/3:smad4 transcriptional activity
(R-HSA-2173795)
Formation of incision complex in gg-ner
(R-HSA-5696395)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Immune system
(R-HSA-168256)
Nucleotide excision repair
(R-HSA-5696398)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-HSA-2173796)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Global genome nucleotide-excision repair
(GO:0070911)
Metal ion binding
(GO:0046872)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pattern specification process
(GO:0007389)
Pml body
(GO:0016605)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of transforming growth factor beta receptor signaling pathway
(GO:0030511)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein polyubiquitination
(GO:0000209)
Protein ubiquitination
(GO:0016567)
Smad binding
(GO:0046332)
Sumo polymer binding
(GO:0032184)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

RN111_HUMAN

Genular Protein ID: 4089809680

Symbol: RN111_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6ZNA4 C9JUS4 H0YN55 Q6P9A4 Q6ZMU2 Q7L428 Q7Z346 Q8N1P9 Q8WUA3 Q9NSR1

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14657019

Title: Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7.

PubMed ID: 14657019

DOI: 10.1093/emboj/cdg632

PubMed ID: 16601693

Title: Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.

PubMed ID: 16601693

DOI: 10.1038/sj.emboj.7601057

PubMed ID: 17591695

Title: Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.

PubMed ID: 17591695

DOI: 10.1128/mcb.00664-07

PubMed ID: 23086935

Title: PolySUMO-binding proteins identified through a string search.

PubMed ID: 23086935

DOI: 10.1074/jbc.m112.410985

PubMed ID: 23751493

Title: RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.

PubMed ID: 23751493

DOI: 10.1083/jcb.201212075

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 26656854

Title: Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity.

PubMed ID: 26656854

DOI: 10.1038/nsmb.3142

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 22411132

Title: NMR-based insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub ligase.

PubMed ID: 22411132

DOI: 10.1002/prot.24048

Sequence Information:

Length: 994
Mass: 108862
Checksum: 7E387321E5F61FAB
Sequence:

MSQWTPEYNE LYTLKVDMKS EIPSDAPKTQ ESLKGILLHP EPIGAAKSFP AGVEMINSKV 
GNEFSHLCDD SQKQEKEMNG NQQEQEKSLV VRKKRKSQQA GPSYVQNCVK ENQGILGLRQ 
HLGTPSDEDN DSSFSDCLSS PSSSLHFGDS DTVTSDEDKE VSVRHSQTIL NAKSRSHSAR 
SHKWPRTETE SVSGLLMKRP CLHGSSLRRL PCRKRFVKNN SSQRTQKQKE RILMQRKKRE 
VLARRKYALL PSSSSSSEND LSSESSSSSS TEGEEDLFVS ASENHQNNPA VPSGSIDEDV 
VVIEASSTPQ VTANEEINVT STDSEVEIVT VGESYRSRST LGHSRSHWSQ GSSSHASRPQ 
EPRNRSRIST VIQPLRQNAA EVVDLTVDED EPTVVPTTSA RMESQATSAS INNSNPSTSE 
QASDTASAVT SSQPSTVSET SATLTSNSTT GTSIGDDSRR TTSSAVTETG PPAMPRLPSC 
CPQHSPCGGS SQNHHALGHP HTSCFQQHGH HFQHHHHHHH TPHPAVPVSP SFSDPACPVE 
RPPQVQAPCG ANSSSGTSYH EQQALPVDLS NSGIRSHGSG SFHGASAFDP CCPVSSSRAA 
IFGHQAAAAA PSQPLSSIDG YGSSMVAQPQ PQPPPQPSLS SCRHYMPPPY ASLTRPLHHQ 
ASACPHSHGN PPPQTQPPPQ VDYVIPHPVH AFHSQISSHA TSHPVAPPPP THLASTAAPI 
PQHLPPTHQP ISHHIPATAP PAQRLHPHEV MQRMEVQRRR MMQHPTRAHE RPPPHPHRMH 
PNYGHGHHIH VPQTMSSHPR QAPERSAWEL GIEAGVTAAT YTPGALHPHL AHYHAPPRLH 
HLQLGALPLM VPDMAGYPHI RYISSGLDGT SFRGPFRGNF EELIHLEERL GNVNRGASQG 
TIERCTYPHK YKKVTTDWFS QRKLHCKQDG EEGTEEDTEE KCTICLSILE EGEDVRRLPC 
MHLFHQVCVD QWLITNKKCP ICRVDIEAQL PSES

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RNF111

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Analysis of the DNA sequence and duplication history of human chromosome 15. PubMed ID: 16572171

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7. PubMed ID: 14657019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. PubMed ID: 16601693

Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. PubMed ID: 17591695

PolySUMO-binding proteins identified through a string search. PubMed ID: 23086935

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response. PubMed ID: 23751493

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity. PubMed ID: 26656854

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

NMR-based insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub ligase. PubMed ID: 22411132