TRPM4 | ENSG00000130529 | NCBI 54795

Details for: TRPM4

Gene ID: 54795

Symbol: TRPM4

Ensembl ID: ENSG00000130529

Description: transient receptor potential cation channel subfamily M member 4

Associated with

Ion channel transport
(R-HSA-983712)
Sensory perception
(R-HSA-9709957)
Sensory perception of sweet, bitter, and umami (glutamate) taste
(R-HSA-9717207)
Sensory perception of taste
(R-HSA-9717189)
Stimuli-sensing channels
(R-HSA-2672351)
Transport of small molecules
(R-HSA-382551)
Trp channels
(R-HSA-3295583)
Adaptive immune response
(GO:0002250)
Atp binding
(GO:0005524)
Calcium-activated cation channel activity
(GO:0005227)
Calcium-mediated signaling
(GO:0019722)
Calcium ion binding
(GO:0005509)
Calcium ion transmembrane transport
(GO:0070588)
Calmodulin binding
(GO:0005516)
Cellular response to atp
(GO:0071318)
Cytosol
(GO:0005829)
Dendritic cell chemotaxis
(GO:0002407)
Endoplasmic reticulum
(GO:0005783)
Golgi apparatus
(GO:0005794)
Inorganic cation transmembrane transport
(GO:0098662)
Ligand-gated calcium channel activity
(GO:0099604)
Membrane
(GO:0016020)
Membrane depolarization during av node cell action potential
(GO:0086045)
Membrane depolarization during bundle of his cell action potential
(GO:0086048)
Membrane depolarization during purkinje myocyte cell action potential
(GO:0086047)
Negative regulation of bone mineralization
(GO:0030502)
Negative regulation of osteoblast differentiation
(GO:0045668)
Neuronal cell body
(GO:0043025)
Nucleoplasm
(GO:0005654)
Plasma membrane
(GO:0005886)
Positive regulation of adipose tissue development
(GO:1904179)
Positive regulation of atrial cardiac muscle cell action potential
(GO:1903949)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of heart rate
(GO:0010460)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0035774)
Positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
(GO:1904199)
Positive regulation of vasoconstriction
(GO:0045907)
Protein binding
(GO:0005515)
Protein homotetramerization
(GO:0051289)
Protein sumoylation
(GO:0016925)
Regulation of heart rate by cardiac conduction
(GO:0086091)
Regulation of t cell cytokine production
(GO:0002724)
Regulation of ventricular cardiac muscle cell action potential
(GO:0098911)
Sodium channel activity
(GO:0005272)
Sodium channel complex
(GO:0034706)
Sodium ion import across plasma membrane
(GO:0098719)

Other Information

Proteins

Transient receptor potential cation channel subfamily M member 4
B4DIX5_HUMAN

Genular Protein ID: 56953232

Symbol: TRPM4_HUMAN

Name: Transient receptor potential cation channel subfamily M member 4

UniProtKB Accession Codes:

Q8TD43 A2RU25 Q7Z5D9 Q96L84 Q9NXV1

Database IDs:

Citations:

PubMed ID: 11535825

Title: Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform.

PubMed ID: 11535825

DOI: 10.1073/pnas.191360198

PubMed ID: 12015988

Title: TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization.

PubMed ID: 12015988

DOI: 10.1016/s0092-8674(02)00719-5

PubMed ID: 12842017

Title: TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel.

PubMed ID: 12842017

DOI: 10.1016/s0960-9822(03)00431-7

PubMed ID: 12799367

Title: Voltage dependence of the Ca2+-activated cation channel TRPM4.

PubMed ID: 12799367

DOI: 10.1074/jbc.m305127200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15472118

Title: Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries.

PubMed ID: 15472118

DOI: 10.1161/01.res.0000147311.54833.03

PubMed ID: 15121803

Title: Functional characterization of a Ca(2+)-activated non-selective cation channel in human atrial cardiomyocytes.

PubMed ID: 15121803

DOI: 10.1113/jphysiol.2004.063974

PubMed ID: 15331675

Title: Decavanadate modulates gating of TRPM4 cation channels.

PubMed ID: 15331675

DOI: 10.1113/jphysiol.2004.070839

PubMed ID: 14758478

Title: Intracellular nucleotides and polyamines inhibit the Ca2+-activated cation channel TRPM4b.

PubMed ID: 14758478

DOI: 10.1007/s00424-003-1221-x

PubMed ID: 15550671

Title: TRPM4 regulates calcium oscillations after T cell activation.

PubMed ID: 15550671

DOI: 10.1126/science.1098845

PubMed ID: 15590641

Title: Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4.

PubMed ID: 15590641

DOI: 10.1074/jbc.m411089200

PubMed ID: 15845551

Title: The selectivity filter of the cation channel TRPM4.

PubMed ID: 15845551

DOI: 10.1074/jbc.m501686200

PubMed ID: 16186107

Title: Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitization.

PubMed ID: 16186107

DOI: 10.1074/jbc.m506965200

PubMed ID: 16806463

Title: TRPM4 controls insulin secretion in pancreatic beta-cells.

PubMed ID: 16806463

DOI: 10.1016/j.ceca.2006.04.032

PubMed ID: 16424899

Title: The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate.

PubMed ID: 16424899

DOI: 10.1038/sj.emboj.7600963

PubMed ID: 16777713

Title: Tissue distribution profiles of the human TRPM cation channel family.

PubMed ID: 16777713

DOI: 10.1080/10799890600637506

PubMed ID: 16407466

Title: A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity.

PubMed ID: 16407466

DOI: 10.1124/mol.105.021154

PubMed ID: 19945433

Title: Cloning and characterization of rat transient receptor potential-melastatin 4 (TRPM4).

PubMed ID: 19945433

DOI: 10.1016/j.bbrc.2009.11.142

PubMed ID: 20625999

Title: TRPM4 enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.

PubMed ID: 20625999

DOI: 10.1002/jcp.22310

PubMed ID: 20656926

Title: Trpm4 differentially regulates Th1 and th2 function by altering calcium signaling and NFAT localization.

PubMed ID: 20656926

DOI: 10.4049/jimmunol.1000880

PubMed ID: 29211723

Title: Electron cryo-microscopy structure of a human TRPM4 channel.

PubMed ID: 29211723

DOI: 10.1038/nature24674

PubMed ID: 29217581

Title: Structure of the human TRPM4 ion channel in a lipid nanodisc.

PubMed ID: 29217581

DOI: 10.1126/science.aar4510

PubMed ID: 19726882

Title: Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I.

PubMed ID: 19726882

DOI: 10.1172/jci38292

PubMed ID: 20562447

Title: Gain-of-function mutations in TRPM4 cause autosomal dominant isolated cardiac conduction disease.

PubMed ID: 20562447

DOI: 10.1161/circgenetics.109.930867

PubMed ID: 21887725

Title: Mutational spectrum in the Ca(2+) -activated cation channel gene TRPM4 in patients with cardiac conductance disturbances.

PubMed ID: 21887725

DOI: 10.1002/humu.21599

PubMed ID: 30528822

Title: Gain-of-Function Mutations in TRPM4 Activation Gate Cause Progressive Symmetric Erythrokeratodermia.

PubMed ID: 30528822

DOI: 10.1016/j.jid.2018.10.044

Sequence Information:

Length: 1214
Mass: 134301
Checksum: 76ADA452690ED8F5
Sequence:

MVVPEKEQSW IPKIFKKKTC TTFIVDSTDP GGTLCQCGRP RTAHPAVAME DAFGAAVVTV 
WDSDAHTTEK PTDAYGELDF TGAGRKHSNF LRLSDRTDPA AVYSLVTRTW GFRAPNLVVS 
VLGGSGGPVL QTWLQDLLRR GLVRAAQSTG AWIVTGGLHT GIGRHVGVAV RDHQMASTGG 
TKVVAMGVAP WGVVRNRDTL INPKGSFPAR YRWRGDPEDG VQFPLDYNYS AFFLVDDGTH 
GCLGGENRFR LRLESYISQQ KTGVGGTGID IPVLLLLIDG DEKMLTRIEN ATQAQLPCLL 
VAGSGGAADC LAETLEDTLA PGSGGARQGE ARDRIRRFFP KGDLEVLQAQ VERIMTRKEL 
LTVYSSEDGS EEFETIVLKA LVKACGSSEA SAYLDELRLA VAWNRVDIAQ SELFRGDIQW 
RSFHLEASLM DALLNDRPEF VRLLISHGLS LGHFLTPMRL AQLYSAAPSN SLIRNLLDQA 
SHSAGTKAPA LKGGAAELRP PDVGHVLRML LGKMCAPRYP SGGAWDPHPG QGFGESMYLL 
SDKATSPLSL DAGLGQAPWS DLLLWALLLN RAQMAMYFWE MGSNAVSSAL GACLLLRVMA 
RLEPDAEEAA RRKDLAFKFE GMGVDLFGEC YRSSEVRAAR LLLRRCPLWG DATCLQLAMQ 
ADARAFFAQD GVQSLLTQKW WGDMASTTPI WALVLAFFCP PLIYTRLITF RKSEEEPTRE 
ELEFDMDSVI NGEGPVGTAD PAEKTPLGVP RQSGRPGCCG GRCGGRRCLR RWFHFWGAPV 
TIFMGNVVSY LLFLLLFSRV LLVDFQPAPP GSLELLLYFW AFTLLCEELR QGLSGGGGSL 
ASGGPGPGHA SLSQRLRLYL ADSWNQCDLV ALTCFLLGVG CRLTPGLYHL GRTVLCIDFM 
VFTVRLLHIF TVNKQLGPKI VIVSKMMKDV FFFLFFLGVW LVAYGVATEG LLRPRDSDFP 
SILRRVFYRP YLQIFGQIPQ EDMDVALMEH SNCSSEPGFW AHPPGAQAGT CVSQYANWLV 
VLLLVIFLLV ANILLVNLLI AMFSYTFGKV QGNSDLYWKA QRYRLIREFH SRPALAPPFI 
VISHLRLLLR QLCRRPRSPQ PSSPALEHFR VYLSKEAERK LLTWESVHKE NFLLARARDK 
RESDSERLKR TSQKVDLALK QLGHIREYEQ RLKVLEREVQ QCSRVLGWVA EALSRSALLP 
PGGPPPPDLP GSKD

Genular Protein ID: 2917764426

Symbol: B4DIX5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DIX5

Database IDs:

Sequence Information:

Length: 860
Mass: 95588
Checksum: 02179DE1685F6A92
Sequence:

MLTRIENATQ AQLPCLLVAG SGGAADCLAE TLEDTLAPGS GGARQGEARD RIRRFFPKGD 
LEVLQAQSFH LEASLMDALL NDRPEFVRLL ISHGLSLGHF LTPMRLAQLY SAAPSNSLIR 
NLLDQASHSA GTKAPALKGG AAELRPPDVG HVLRMLLGKM CAPRYPSGGA WDPHPGQGFG 
ESMYLLSDKA TSPLSLDAGL GQAPWSDLLL WALLLNRAQM AMYFWEMGSN AVSSALGACL 
LLRVMARLEP DAEEAARRKD LAFKFEGMGV DLFGECYRSS EVRAARLLLR RCPLWGDATC 
LQLAMQADAR AFFAQDGVQS LLTQKWWGDM ASTTPIWALV LAFFCPPLIY TRLITFRKSE 
EEPTREELEF DMDSVINGEG PVGTADPAEK TPLGVPRQSG RPGCCGGRCG GRRCLRRWFH 
FWGAPVTIFM GNVVSYLLFL LLFSRVLLVD FQPAPPGSLE LLLYFWAFTL LCEELRQGLS 
GGGGSLASGG PGPGHASLSQ RLRLYLADSW NQCDLVALTC FLLGVGCRLT PGLYHLGRTV 
LCIDFMVFTV RLLHIFTVNK QLGPKIVIVS KMMKDVFFFL FFLGVWLVAY GVATEGLLRP 
RDSDFPSILR RVFYRPYLQI FGQIPQEDMD VALMEHSNCS SEPGFWAHPP GAQAGTCVSQ 
YANWLVVLLL VIFLLVANIL LVNLLIAMFS YTFGKVQGNS DLYWKAQRYR LIREFHSRPA 
LAPPFIVISH LRLLLRQLCR RPRSPQPSSP ALEHFRVYLS KEAERKLLTW ESVHKENFLL 
ARARDKRESD SERLKRTSQK VDLALKQLGH IREYEQRLKV LEREVQQCSR VLGWVAEALS 
RSALLPPGGP PPPDLPGSKD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TRPM4

Associated with

Other Information

Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform. PubMed ID: 11535825

TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization. PubMed ID: 12015988

TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel. PubMed ID: 12842017

Voltage dependence of the Ca2+-activated cation channel TRPM4. PubMed ID: 12799367

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries. PubMed ID: 15472118

Functional characterization of a Ca(2+)-activated non-selective cation channel in human atrial cardiomyocytes. PubMed ID: 15121803

Decavanadate modulates gating of TRPM4 cation channels. PubMed ID: 15331675

Intracellular nucleotides and polyamines inhibit the Ca2+-activated cation channel TRPM4b. PubMed ID: 14758478

TRPM4 regulates calcium oscillations after T cell activation. PubMed ID: 15550671

Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. PubMed ID: 15590641

The selectivity filter of the cation channel TRPM4. PubMed ID: 15845551

Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitization. PubMed ID: 16186107

TRPM4 controls insulin secretion in pancreatic beta-cells. PubMed ID: 16806463

The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate. PubMed ID: 16424899

Tissue distribution profiles of the human TRPM cation channel family. PubMed ID: 16777713

A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity. PubMed ID: 16407466

Cloning and characterization of rat transient receptor potential-melastatin 4 (TRPM4). PubMed ID: 19945433

TRPM4 enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. PubMed ID: 20625999

Trpm4 differentially regulates Th1 and th2 function by altering calcium signaling and NFAT localization. PubMed ID: 20656926

Electron cryo-microscopy structure of a human TRPM4 channel. PubMed ID: 29211723

Structure of the human TRPM4 ion channel in a lipid nanodisc. PubMed ID: 29217581

Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I. PubMed ID: 19726882

Gain-of-function mutations in TRPM4 cause autosomal dominant isolated cardiac conduction disease. PubMed ID: 20562447

Mutational spectrum in the Ca(2+) -activated cation channel gene TRPM4 in patients with cardiac conductance disturbances. PubMed ID: 21887725

Gain-of-Function Mutations in TRPM4 Activation Gate Cause Progressive Symmetric Erythrokeratodermia. PubMed ID: 30528822