Details for: TRIT1

Gene ID: 54802

Symbol: TRIT1

Ensembl ID: ENSG00000043514

Description: tRNA isopentenyltransferase 1

Associated with

Other Information

Genular Protein ID: 2994220501

Symbol: MOD5_HUMAN

Name: tRNA dimethylallyltransferase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11111046

Title: Cloning of a human tRNA isopentenyl transferase.

PubMed ID: 11111046

DOI: 10.1016/s0378-1119(00)00421-2

PubMed ID: 15870694

Title: Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer.

PubMed ID: 15870694

DOI: 10.1038/sj.onc.1208687

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11560893

Title: Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria.

PubMed ID: 11560893

DOI: 10.1093/genetics/159.1.147

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24126054

Title: Human cells have a limited set of tRNA anticodon loop substrates of the tRNA isopentenyltransferase TRIT1 tumor suppressor.

PubMed ID: 24126054

DOI: 10.1128/mcb.01041-13

PubMed ID: 24901367

Title: Defective i6A37 modification of mitochondrial and cytosolic tRNAs results from pathogenic mutations in TRIT1 and its substrate tRNA.

PubMed ID: 24901367

DOI: 10.1371/journal.pgen.1004424

PubMed ID: 32088416

Title: Expansion of the phenotype of biallelic variants in TRIT1.

PubMed ID: 32088416

DOI: 10.1016/j.ejmg.2020.103882

PubMed ID: 34774131

Title: Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs.

PubMed ID: 34774131

DOI: 10.1016/j.molcel.2021.10.018

PubMed ID: 28185376

Title: Matchmaking facilitates the diagnosis of an autosomal-recessive mitochondrial disease caused by biallelic mutation of the tRNA isopentenyltransferase (TRIT1) gene.

PubMed ID: 28185376

DOI: 10.1002/humu.23196

PubMed ID: 32948376

Title: The first Korean cases of combined oxidative phosphorylation deficiency 35 with two novel TRIT1 mutations in two siblings confirmed by clinical and molecular investigation.

PubMed ID: 32948376

DOI: 10.1016/j.braindev.2020.08.016

Sequence Information:

  • Length: 467
  • Mass: 52725
  • Checksum: 634469919D7F56A5
  • Sequence:
  • MASVAAARAV PVGSGLRGLQ RTLPLVVILG ATGTGKSTLA LQLGQRLGGE IVSADSMQVY 
    EGLDIITNKV SAQEQRICRH HMISFVDPLV TNYTVVDFRN RATALIEDIF ARDKIPIVVG 
    GTNYYIESLL WKVLVNTKPQ EMGTEKVIDR KVELEKEDGL VLHKRLSQVD PEMAAKLHPH 
    DKRKVARSLQ VFEETGISHS EFLHRQHTEE GGGPLGGPLK FSNPCILWLH ADQAVLDERL 
    DKRVDDMLAA GLLEELRDFH RRYNQKNVSE NSQDYQHGIF QSIGFKEFHE YLITEGKCTL 
    ETSNQLLKKG IEALKQVTKR YARKQNRWVK NRFLSRPGPI VPPVYGLEVS DVSKWEESVL 
    EPALEIVQSF IQGHKPTATP IKMPYNEAEN KRSYHLCDLC DRIIIGDREW AAHIKSKSHL 
    NQLKKRRRLD SDAVNTIESQ SVSPDHNKEP KEKGSPGQND QELKCSV

Genular Protein ID: 3437265805

Symbol: Q3T7C7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15870694

Title: Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer.

PubMed ID: 15870694

DOI: 10.1038/sj.onc.1208687

Sequence Information:

  • Length: 411
  • Mass: 47257
  • Checksum: 93636766D89E1273
  • Sequence:
  • MQVYEGLDII TNKVSAQEQR ICRHHMISFV DPLVTNYTVV DFRNRATALI EDIFARDKIP 
    IVVGGTNYYI ESLLWKVLVN TKPQEMGTEK VIDRKVELEK EDGLVLHKRL SQVDPEMAAK 
    LHPHDKRKVA RSLQVFEETG ISHSEFLHRQ HTEEGGGPLG GPLKFSNPCI LWLHADQAVL 
    DERLDKRVDD MLAAGLLEEL RDFHRRYNQK NVSENSQDYQ HGIFQSIGFK EFHEYLITEG 
    KCTLETSNQL LKKGIEALKQ VTKRYARKQN RWVKNRFLSR PGPIVPPVYG LEVSDVSKWE 
    ESVLEPALEI VQSFIQGHKP TATPIKMPYN EAENKRSYHL CDLCDRIIIG DREWAAHIKS 
    KSHLNQLKKR RRLDSDAVNT IESQSVSPDH NKEPKEKGSP GQNDQELKCS V

Genular Protein ID: 2535423492

Symbol: Q53F11_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 467
  • Mass: 52728
  • Checksum: 634469943D7F56A5
  • Sequence:
  • MASVAAARAV PVGSGLRGLQ RTLPLVVILG ATGTGKSTLA LQLGQRLGGE IVSADSMQVY 
    EGLDIITNKV SAQEQRICRH HMISFVDPLV TNYTVVDFRN RATALIEDIF ARDKIPIVVG 
    GTNYYIESLL WKVLVNTKPQ EMGTEKVIDR KVELEKEDGL VLHKRLSQVD PEMAAKLHPH 
    DKRKVARSLQ VFEETGISHS EFLHRQHTEE GGGPLGGPLK FSNPCILWLH ADQAVLDERL 
    DKRVDDMLAA GLLEELRDFH RRYNQKNVSE NSQDYQHGIF QSIGFKEFHE YLITEGKCTL 
    ETSNQLLKKG IEALKQVTKR YARKQNRWVK NRFLSRPGPI VPPVYGLEVS DVSKWEESVL 
    EPALEIVQSF IQGHKPTATP IKMPYNEAEN KRSYHLCDLC DRIIIGDREW AAHIKSKSHL 
    NQLKKRRRLD SDAVNTIESQ SVSPDHNKEP KEKGSPGQND QELMCSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.