NDE1 | ENSG00000072864 | NCBI 54820

Details for: NDE1

Gene ID: 54820

Symbol: NDE1

Ensembl ID: ENSG00000072864

Description: nudE neurodevelopment protein 1

Associated with

Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Aurka activation by tpx2
(R-HSA-8854518)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Centrosome maturation
(R-HSA-380287)
Cilium assembly
(R-HSA-5617833)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
G2/m transition
(R-HSA-69275)
Loss of nlp from mitotic centrosomes
(R-HSA-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-HSA-380284)
Mitotic anaphase
(R-HSA-68882)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Recruitment of mitotic centrosome proteins and complexes
(R-HSA-380270)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Cell division
(GO:0051301)
Cell migration
(GO:0016477)
Centrosome
(GO:0005813)
Centrosome duplication
(GO:0051298)
Centrosome localization
(GO:0051642)
Cerebral cortex development
(GO:0021987)
Chromosome segregation
(GO:0007059)
Cleavage furrow
(GO:0032154)
Cytosol
(GO:0005829)
Establishment of chromosome localization
(GO:0051303)
Establishment of mitotic spindle orientation
(GO:0000132)
Identical protein binding
(GO:0042802)
Kinesin complex
(GO:0005871)
Kinetochore
(GO:0000776)
Membrane
(GO:0016020)
Microtubule
(GO:0005874)
Microtubule binding
(GO:0008017)
Microtubule nucleation
(GO:0007020)
Mitotic centrosome separation
(GO:0007100)
Neuroblast proliferation
(GO:0007405)
Neuron migration
(GO:0001764)
Protein binding
(GO:0005515)
Spindle pole centrosome
(GO:0031616)
Synapse
(GO:0045202)
Vesicle transport along microtubule
(GO:0047496)

Other Information

Proteins

Nuclear distribution protein nudE homolog 1
X5DP35_HUMAN

Genular Protein ID: 2047366915

Symbol: NDE1_HUMAN

Name: Nuclear distribution protein nudE homolog 1

UniProtKB Accession Codes:

Q9NXR1 Q49AQ2

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12556484

Title: Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.

PubMed ID: 12556484

DOI: 10.1128/mcb.23.4.1239-1250.2003

PubMed ID: 16291865

Title: Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly.

PubMed ID: 16291865

DOI: 10.1091/mbc.e05-04-0360

PubMed ID: 16682949

Title: Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation.

PubMed ID: 16682949

DOI: 10.1038/sj.onc.1209637

PubMed ID: 17600710

Title: Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes.

PubMed ID: 17600710

DOI: 10.1016/j.cub.2007.05.077

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19927128

Title: Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity.

PubMed ID: 19927128

DOI: 10.1038/emboj.2009.325

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21529752

Title: The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis.

PubMed ID: 21529752

DOI: 10.1016/j.ajhg.2011.03.019

PubMed ID: 21529751

Title: Human mutations in NDE1 cause extreme microcephaly with lissencephaly.

PubMed ID: 21529751

DOI: 10.1016/j.ajhg.2011.04.003

PubMed ID: 22526350

Title: Novel NDE1 homozygous mutation resulting in microhydranencephaly and not microlyssencephaly.

PubMed ID: 22526350

DOI: 10.1007/s10048-012-0326-9

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 335
Mass: 37721
Checksum: FC0BDD8BB90324B8
Sequence:

MEDSGKTFSS EEEEANYWKD LAMTYKQRAE NTQEELREFQ EGSREYEAEL ETQLQQIETR 
NRDLLSENNR LRMELETIKE KFEVQHSEGY RQISALEDDL AQTKAIKDQL QKYIRELEQA 
NDDLERAKRA TIMSLEDFEQ RLNQAIERNA FLESELDEKE NLLESVQRLK DEARDLRQEL 
AVQQKQEKPR TPMPSSVEAE RTDTAVQATG SVPSTPIAHR GPSSSLNTPG SFRRGLDDST 
GGTPLTPAAR ISALNIVGDL LRKVGALESK LASCRNLVYD QSPNRTGGPA SGRSSKNRDG 
GERRPSSTSV PLGDKGLDTS CRWLSKSTTR SSSSC

Genular Protein ID: 1544718943

Symbol: X5DP35_HUMAN

Name: N/A

UniProtKB Accession Codes:

X5DP35

Database IDs:

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

Length: 339
Mass: 39153
Checksum: AAB8C2BE071459B8
Sequence:

MEDSGKTFSS EEEEANYWKD LAMTYKQRAE NTQEELREFQ EGSREYEAEL ETQLQQIETR 
NRDLLSENNR LRMELETIKE KFEVQHSEGY RQISALEDDL AQTKAIKDQL QKYIRELEQA 
NDDLERAKRA TIMSLEDFEQ RLNQAIERNA FLESELDEKE NLLESVQRLK DEARDLRQEL 
AVQQKQEKPR TPMPSSVEAE RTDTAVQATG SVPSTPIAHR GPSSSLNTPG SFRRGLDDST 
GGTPLTPAAR ISALNIVGDL LRKVGRFNKV NQRVKDSRSG FPTSYKRSWI IGTGVQTRFL 
PEPRVRSVPK PNRWPSLWAE QQEQRWRGET AKQHQRAFG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NDE1

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle. PubMed ID: 12556484

Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. PubMed ID: 16291865

Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation. PubMed ID: 16682949

Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes. PubMed ID: 17600710

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity. PubMed ID: 19927128

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis. PubMed ID: 21529752

Human mutations in NDE1 cause extreme microcephaly with lissencephaly. PubMed ID: 21529751

Novel NDE1 homozygous mutation resulting in microhydranencephaly and not microlyssencephaly. PubMed ID: 22526350

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. PubMed ID: 24722188