Details for: NSUN2

Gene ID: 54888

Symbol: NSUN2

Ensembl ID: ENSG00000037474

Description: NOP2/Sun RNA methyltransferase 2

Associated with

Other Information

Genular Protein ID: 1179492170

Symbol: NSUN2_HUMAN

Name: mRNA cytosine C(5)-methyltransferase

UniProtKB Accession Codes:

Q08J23 A8K529 B2RNR4 B3KP09 B4DQW2 G3V1R4 Q9BVN4 Q9H858 Q9NXD9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 1 CTD 1 ChEBI 29 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 20 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 17215513

Title: Aurora-B regulates RNA methyltransferase NSUN2.

PubMed ID: 17215513

DOI: 10.1091/mbc.e06-11-1021

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17071714

Title: Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA).

PubMed ID: 17071714

DOI: 10.1093/nar/gkl765

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19596847

Title: The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability.

PubMed ID: 19596847

DOI: 10.1083/jcb.200810180

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22541559

Title: Mutations in NSUN2 cause autosomal-recessive intellectual disability.

PubMed ID: 22541559

DOI: 10.1016/j.ajhg.2012.03.021

PubMed ID: 22395603

Title: The tRNA methyltransferase NSun2 stabilizes p16INK[4] mRNA by methylating the 3'-untranslated region of p16.

PubMed ID: 22395603

DOI: 10.1038/ncomms1692

PubMed ID: 22995836

Title: The human tRNA m (5) C methyltransferase Misu is multisite-specific.

PubMed ID: 22995836

DOI: 10.4161/rna.22180

PubMed ID: 23871666

Title: NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs.

PubMed ID: 23871666

DOI: 10.1016/j.celrep.2013.06.029

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28418038

Title: 5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m5C reader.

PubMed ID: 28418038

DOI: 10.1038/cr.2017.55

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31358969

Title: 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs.

PubMed ID: 31358969

DOI: 10.1038/s41556-019-0361-y

PubMed ID: 31186410

Title: Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation.

PubMed ID: 31186410

DOI: 10.1038/s41467-019-10020-7

PubMed ID: 31276587

Title: NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs.

PubMed ID: 31276587

DOI: 10.1093/nar/gkz559

PubMed ID: 31287866

Title: Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs.

PubMed ID: 31287866

DOI: 10.1093/nar/gkz575

PubMed ID: 31199786

Title: Cytosine-5 RNA methylation links protein synthesis to cell metabolism.

PubMed ID: 31199786

DOI: 10.1371/journal.pbio.3000297

PubMed ID: 34556860

Title: Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation.

PubMed ID: 34556860

DOI: 10.1038/s41589-021-00874-8

PubMed ID: 22541562

Title: Mutation in NSUN2, which encodes an RNA methyltransferase, causes autosomal-recessive intellectual disability.

PubMed ID: 22541562

DOI: 10.1016/j.ajhg.2012.03.023

Sequence Information:

  • Length: 767
  • Mass: 86471
  • Checksum: FE4B34309978A8D2
  • Sequence:
    • MGRRSRGRRL QQQQRPEDAE DGAEGGGKRG EAGWEGGYPE IVKENKLFEH YYQELKIVPE 
GEWGQFMDAL REPLPATLRI TGYKSHAKEI LHCLKNKYFK ELEDLEVDGQ KVEVPQPLSW 
YPEELAWHTN LSRKILRKSP HLEKFHQFLV SETESGNISR QEAVSMIPPL LLNVRPHHKI 
LDMCAAPGSK TTQLIEMLHA DMNVPFPEGF VIANDVDNKR CYLLVHQAKR LSSPCIMVVN 
HDASSIPRLQ IDVDGRKEIL FYDRILCDVP CSGDGTMRKN IDVWKKWTTL NSLQLHGLQL 
RIATRGAEQL AEGGRMVYST CSLNPIEDEA VIASLLEKSE GALELADVSN ELPGLKWMPG 
ITQWKVMTKD GQWFTDWDAV PHSRHTQIRP TMFPPKDPEK LQAMHLERCL RILPHHQNTG 
GFFVAVLVKK SSMPWNKRQP KLQGKSAETR ESTQLSPADL TEGKPTDPSK LESPSFTGTG 
DTEIAHATED LENNGSKKDG VCGPPPSKKM KLFGFKEDPF VFIPEDDPLF PPIEKFYALD 
PSFPRMNLLT RTTEGKKRQL YMVSKELRNV LLNNSEKMKV INTGIKVWCR NNSGEEFDCA 
FRLAQEGIYT LYPFINSRII TVSMEDVKIL LTQENPFFRK LSSETYSQAK DLAKGSIVLK 
YEPDSANPDA LQCPIVLCGW RGKASIRTFV PKNERLHYLR MMGLEVLGEK KKEGVILTNE 
SAASTGQPDN DVTEGQRAGE PNSPDAEEAN SPDVTAGCDP AGVHPPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.