Details for: AUH

Gene ID: 549

Symbol: AUH

Ensembl ID: ENSG00000148090

Description: AU RNA binding methylglutaconyl-CoA hydratase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 272.9110
    Cell Significance Index: -42.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 169.1745
    Cell Significance Index: -42.9100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 103.7511
    Cell Significance Index: -42.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 87.0960
    Cell Significance Index: -41.1200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 82.8047
    Cell Significance Index: -33.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.2975
    Cell Significance Index: -33.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.0884
    Cell Significance Index: -43.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.7223
    Cell Significance Index: -36.7600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.2543
    Cell Significance Index: -40.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.6605
    Cell Significance Index: -25.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.1352
    Cell Significance Index: -43.9400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.9553
    Cell Significance Index: 35.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.8312
    Cell Significance Index: 158.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.2484
    Cell Significance Index: 57.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.1784
    Cell Significance Index: 167.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0934
    Cell Significance Index: 419.9400
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.9807
    Cell Significance Index: 12.2200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.9374
    Cell Significance Index: 24.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.9055
    Cell Significance Index: 45.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9036
    Cell Significance Index: 682.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.8994
    Cell Significance Index: 37.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8958
    Cell Significance Index: 376.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6714
    Cell Significance Index: 165.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5329
    Cell Significance Index: 94.2200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.5190
    Cell Significance Index: 32.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.3896
    Cell Significance Index: 93.4400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.1758
    Cell Significance Index: 28.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0389
    Cell Significance Index: 62.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9722
    Cell Significance Index: 27.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9216
    Cell Significance Index: 34.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8216
    Cell Significance Index: 36.3400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8025
    Cell Significance Index: 22.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7123
    Cell Significance Index: 19.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6577
    Cell Significance Index: 29.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6450
    Cell Significance Index: 40.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.5678
    Cell Significance Index: 9.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5200
    Cell Significance Index: 979.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4928
    Cell Significance Index: 5.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4445
    Cell Significance Index: 401.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4017
    Cell Significance Index: 5.4800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3877
    Cell Significance Index: 6.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3844
    Cell Significance Index: 11.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3777
    Cell Significance Index: 239.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3248
    Cell Significance Index: 8.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2842
    Cell Significance Index: 7.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2730
    Cell Significance Index: 12.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2104
    Cell Significance Index: 95.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1878
    Cell Significance Index: 35.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1805
    Cell Significance Index: 12.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1660
    Cell Significance Index: 90.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1604
    Cell Significance Index: 28.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1529
    Cell Significance Index: 282.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1524
    Cell Significance Index: 234.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1327
    Cell Significance Index: 16.3200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1307
    Cell Significance Index: 1.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1275
    Cell Significance Index: 173.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1107
    Cell Significance Index: 3.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0772
    Cell Significance Index: 4.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0738
    Cell Significance Index: 32.6200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0383
    Cell Significance Index: 0.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0335
    Cell Significance Index: 24.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0131
    Cell Significance Index: 1.8000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0053
    Cell Significance Index: -0.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0196
    Cell Significance Index: -2.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0276
    Cell Significance Index: -4.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0399
    Cell Significance Index: -29.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0434
    Cell Significance Index: -2.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0455
    Cell Significance Index: -34.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0648
    Cell Significance Index: -4.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0666
    Cell Significance Index: -8.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0673
    Cell Significance Index: -37.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0697
    Cell Significance Index: -43.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0795
    Cell Significance Index: -8.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1159
    Cell Significance Index: -2.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1218
    Cell Significance Index: -14.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1290
    Cell Significance Index: -37.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1325
    Cell Significance Index: -16.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1655
    Cell Significance Index: -19.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1879
    Cell Significance Index: -19.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1961
    Cell Significance Index: -41.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2083
    Cell Significance Index: -4.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2171
    Cell Significance Index: -24.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2365
    Cell Significance Index: -15.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2528
    Cell Significance Index: -20.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3558
    Cell Significance Index: -9.6900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3797
    Cell Significance Index: -5.6100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3930
    Cell Significance Index: -4.9000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.4586
    Cell Significance Index: -7.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4638
    Cell Significance Index: -32.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4739
    Cell Significance Index: -9.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5112
    Cell Significance Index: -16.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5256
    Cell Significance Index: -27.3800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.5297
    Cell Significance Index: -6.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5437
    Cell Significance Index: -17.8000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5530
    Cell Significance Index: -6.9800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5743
    Cell Significance Index: -11.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5819
    Cell Significance Index: -15.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5892
    Cell Significance Index: -17.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5996
    Cell Significance Index: -12.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The AUH gene exhibits several key characteristics that highlight its significance in metabolic pathways: 1. **RNA binding protein:** The AUH gene encodes for an RNA binding protein that specifically interacts with RNA, suggesting its role in regulating gene expression. 2. **Methylglutaconyl-CoA hydratase activity:** The enzyme catalyzes the hydration of methylglutaconyl-CoA, a key intermediate in the breakdown of branched-chain amino acids and fatty acids. 3. **Significant tissue expression:** The AUH gene is significantly expressed in various tissues, including alveolar type 2 fibroblasts, basal epithelial cells of prostatic ducts, and renal principal cells, highlighting its importance in maintaining tissue homeostasis. 4. **Pathway involvement:** The AUH gene is involved in several metabolic pathways, including branched-chain amino acid catabolism, fatty acid beta-oxidation, and itaconyl-CoA hydratase activity. **Pathways and Functions:** The AUH gene plays a critical role in several metabolic pathways, including: 1. **Branched-chain amino acid catabolism:** The AUH gene is involved in the breakdown of branched-chain amino acids, such as leucine, which is essential for maintaining protein homeostasis. 2. **Fatty acid beta-oxidation:** The AUH gene is also involved in the breakdown of fatty acids, which is essential for energy production and maintaining energy homeostasis. 3. **Itaconyl-CoA hydratase activity:** The AUH gene is involved in the hydration of itaconyl-CoA, a key intermediate in the breakdown of branched-chain amino acids and fatty acids. 4. **Mitochondrial matrix:** The AUH gene is expressed in the mitochondrial matrix, highlighting its role in regulating mitochondrial function and energy production. **Clinical Significance:** Dysregulation of the AUH gene has been implicated in various diseases, including: 1. **Metabolic disorders:** Dysregulation of the AUH gene has been linked to metabolic disorders, such as diabetic ketoacidosis and fatty acid oxidation disorders. 2. **Neurodegenerative diseases:** The AUH gene has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, highlighting its role in regulating gene expression and maintaining neuronal function. 3. **Cancer:** The AUH gene has been linked to cancer, highlighting its role in regulating cell growth and proliferation. In conclusion, the AUH gene is a critical regulator of metabolic pathways, particularly in the catabolism of branched-chain amino acids and fatty acids. Its dysregulation has been implicated in various diseases, highlighting the importance of maintaining AUH gene expression and function. Further research is needed to fully elucidate the role of the AUH gene in human health and disease.

Genular Protein ID: 3145388715

Symbol: AUHM_HUMAN

Name: AU-specific RNA-binding enoyl-CoA hydratase

UniProtKB Accession Codes:

Q13825 B1ALV7 B1ALV8 Q8WUE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 Ensembl 2 EvolutionaryTrace 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 8 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7892223

Title: AUH, a gene encoding an AU-specific RNA binding protein with intrinsic enoyl-CoA hydratase activity.

PubMed ID: 7892223

DOI: 10.1073/pnas.92.6.2051

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12434311

Title: 3-methylglutaconic aciduria type I is caused by mutations in AUH.

PubMed ID: 12434311

DOI: 10.1086/344712

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16640564

Title: Biochemical characterization of human 3-methylglutaconyl-CoA hydratase and its role in leucine metabolism.

PubMed ID: 16640564

DOI: 10.1111/j.1742-4658.2006.05218.x

PubMed ID: 29056341

Title: The human knockout gene CLYBL connects itaconate to vitamin B12.

PubMed ID: 29056341

DOI: 10.1016/j.cell.2017.09.051

PubMed ID: 11738050

Title: Crystal structure of human AUH protein, a single-stranded RNA binding homolog of enoyl-CoA hydratase.

PubMed ID: 11738050

DOI: 10.1016/s0969-2126(01)00686-4

PubMed ID: 12655555

Title: Mutations in the AUH gene cause 3-methylglutaconic aciduria type I.

PubMed ID: 12655555

DOI: 10.1002/humu.10202

Sequence Information:

  • Length: 339
  • Mass: 35609
  • Checksum: E04FEB95933FB30B
  • Sequence:
    • MAAAVAAAPG ALGSLHAGGA RLVAACSAWL CPGLRLPGSL AGRRAGPAIW AQGWVPAAGG 
PAPKRGYSSE MKTEDELRVR HLEEENRGIV VLGINRAYGK NSLSKNLIKM LSKAVDALKS 
DKKVRTIIIR SEVPGIFCAG ADLKERAKMS SSEVGPFVSK IRAVINDIAN LPVPTIAAID 
GLALGGGLEL ALACDIRVAA SSAKMGLVET KLAIIPGGGG TQRLPRAIGM SLAKELIFSA 
RVLDGKEAKA VGLISHVLEQ NQEGDAAYRK ALDLAREFLP QGPVAMRVAK LAINQGMEVD 
LVTGLAIEEA CYAQTIPTKD RLEGLLAFKE KRPPRYKGE

Genular Protein ID: 3725633119

Symbol: B4DYI6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DYI6

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 IntAct 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 255
  • Mass: 26335
  • Checksum: 07D5F5EDE1273C7A
  • Sequence:
    • MAAAVAAAPG ALGSLHAGGA RLVAACSAWL CPGLRLPGSL AGRRAGPAIW AQGWVPAAGG 
PAPKRGYSSE MKTEDELRVR HLEEENRGIV VLGINRAYGK NSLSKNLIKM LSKAVDALKS 
DKKVRTIIIR SEVPGIFCAG ADLKERAKMS SSEVGPFVSK IRAVINDIAN LPVPTIAAID 
GLALGGGLEL ALACDIRVAA SSAKMGLVET KLAIIPGGVT SSTEVLNPSK SSMKIGIIIF 
QTPVNIDILA SSHES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.