Details for: MKS1

Gene ID: 54903

Symbol: MKS1

Ensembl ID: ENSG00000011143

Description: MKS transition zone complex subunit 1

Associated with

Other Information

Genular Protein ID: 1375619551

Symbol: MKS1_HUMAN

Name: Meckel syndrome type 1 protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16415886

Title: MKS1, encoding a component of the flagellar apparatus basal body proteome, is mutated in Meckel syndrome.

PubMed ID: 16415886

DOI: 10.1038/ng1714

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17185389

Title: The Meckel-Gruber syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation.

PubMed ID: 17185389

DOI: 10.1093/hmg/ddl459

PubMed ID: 19515853

Title: Ciliary and centrosomal defects associated with mutation and depletion of the Meckel syndrome genes MKS1 and MKS3.

PubMed ID: 19515853

DOI: 10.1093/hmg/ddp272

PubMed ID: 19208769

Title: Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins.

PubMed ID: 19208769

DOI: 10.1242/jcs.028621

PubMed ID: 22121117

Title: A meckelin-filamin A interaction mediates ciliogenesis.

PubMed ID: 22121117

DOI: 10.1093/hmg/ddr557

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26595381

Title: TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome.

PubMed ID: 26595381

DOI: 10.1038/ncb3273

PubMed ID: 18327255

Title: Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome.

PubMed ID: 18327255

DOI: 10.1038/ng.97

PubMed ID: 19466712

Title: Mutation spectrum of Meckel syndrome genes: one group of syndromes or several distinct groups?

PubMed ID: 19466712

DOI: 10.1002/humu.21057

PubMed ID: 24886560

Title: Mutations in B9D1 and MKS1 cause mild Joubert syndrome: expanding the genetic overlap with the lethal ciliopathy Meckel syndrome.

PubMed ID: 24886560

DOI: 10.1186/1750-1172-9-72

PubMed ID: 27377014

Title: MKS1 mutations cause Joubert syndrome with agenesis of the corpus callosum.

PubMed ID: 27377014

DOI: 10.1016/j.ejmg.2016.06.007

PubMed ID: 26490104

Title: MKS1 regulates ciliary INPP5E levels in Joubert syndrome.

PubMed ID: 26490104

DOI: 10.1136/jmedgenet-2015-103250

Sequence Information:

  • Length: 559
  • Mass: 64528
  • Checksum: 3E4EBFDAFA8FB39D
  • Sequence:
  • MAETVWSTDT GEAVYRSRDP VRNLRLRVHL QRITSSNFLH YQPAAELGKD LIDLATFRPQ 
    PTASGHRPEE DEEEEIVIGW QEKLFSQFEV DLYQNETACQ SPLDYQYRQE ILKLENSGGK 
    KNRRIFTYTD SDRYTNLEEH CQRMTTAASE VPSFLVERMA NVRRRRQDRR GMEGGILKSR 
    IVTWEPSEEF VRNNHVINTP LQTMHIMADL GPYKKLGYKK YEHVLCTLKV DSNGVITVKP 
    DFTGLKGPYR IETEGEKQEL WKYTIDNVSP HAQPEEEERE RRVFKDLYGR HKEYLSSLVG 
    TDFEMTVPGA LRLFVNGEVV SAQGYEYDNL YVHFFVELPT AHWSSPAFQQ LSGVTQTCTT 
    KSLAMDKVAH FSYPFTFEAF FLHEDESSDA LPEWPVLYCE VLSLDFWQRY RVEGYGAVVL 
    PATPGSHTLT VSTWRPVELG TVAELRRFFI GGSLELEDLS YVRIPGSFKG ERLSRFGLRT 
    ETTGTVTFRL HCLQQSRAFM ESSSLQKRMR SVLDRLEGFS QQSSIHNVLE AFRRARRRMQ 
    EARESLPQDL VSPSGTLVS

Genular Protein ID: 1478080360

Symbol: A0A7I2V2M0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 561
  • Mass: 63648
  • Checksum: B830CBC9789505F6
  • Sequence:
  • MAETVWSTDT GEAVYRSRDP VRNLRLRVHL QRITSSNFLH YQPAAELGKD LIDLATFRPQ 
    PTASGHRPEE DEEEEIVIGW QEKLFSQFEV DLYQNETACQ SPLDYQYRQE ILKLENSGGK 
    KNRRIFTYTD SDRYTNLEEH CQRMTTAASE VPSFLVERMA NVRRRRQDRR GMEGGILKSR 
    IVTWEPSEEF VRNNHVINTP LQTMHIMADL GPYKKLGYKK YEHVLCTLKV DSNGVITVKP 
    DFTGLKGPYR IETEGEKQEL WKYTIDNVSP HAQPEEEERE RRVFKDLYGR HKEYLSSLVG 
    TDFEMTVPGA LRLFVNGEVV SAQGYEYDNL YVHFFVELPT AHWSSPAFQQ LSGVTQTCTT 
    KSLAMDKVAH FSYPFTFEAF FLHEDESSDA LPEWPVLYCE VLSLDFWQRY RVEGYGAVVL 
    PATPGSHTLT VSTWRPVELG TVAELRRFFI GGSLELEDLS YVRIPGSFKG LHGIELPSEK 
    DAECVGPSGR VQPAEFHSQC ARGLPSSPAP HAGGPGKPPA GPSEPLWNPG LLAHSSPGPQ 
    CKRTRWGISE ASALLPLRLS D

Genular Protein ID: 1271754297

Symbol: H0Y2S2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 456
  • Mass: 52755
  • Checksum: 7C76CB8CE0FCF011
  • Sequence:
  • MAETVWSTDT GEAVYRSRDP VRNLRLRVHL QRITSSNFLH YQPAAELGKD LIDLATFRPQ 
    PTASGHRPEE DEEEEIVIGW QEKLFSQFEV DLYQNETACQ SPLDYQYRQE ILKLENSGGK 
    KNRRIFTYTD SDRYTNLEEH CQRMTTAASE VPSFLVERMA NVRRRRQDRR GMEGGILKSR 
    IVTWEPSEEF VRNNHVINTP LQTMHIMADL GPYKKLGYKK YEHVLCTLKV DSNGVITVKP 
    DFTGLKGPYR IETEGEKQEL WKYTIDNVSP HAQPEEEERE RRVFKDLYGR HKEYLSSLVG 
    TDFEMTVPGA LRLFVNGEVV SAQGYEYDNL YVHFFVELPT AHWSSPAFQQ LSGVTQTCTT 
    KSLAMDKVAH FSYPFTFEAF FLHEDESSDA LPEWPVLYCE VLSLDFWQRY RVEGYGAVVL 
    PATPGPSWNR APFRKGCGVC WTVWKGSASR VPFTMC

Genular Protein ID: 2319326387

Symbol: B4DVC5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 356
  • Mass: 40799
  • Checksum: EFC45730F9493BD1
  • Sequence:
  • MHIMADLGPY KKLGYKKYEH VLCTLKVDSN GVITVKPDFT GLKGPYRIET EGEKQELWKY 
    TIDNVSPHAQ PEEEERERRV FKDLYGRHKE YLSSLVGTDF EMTVPGALRL FVNGEVVSAQ 
    GYEYDNLYVH FFVELPTAHW SSPAFQQLSG VTQTYTTKSL AMDKVAHFSY PFTFEAFFLH 
    EDESSDALPE WPVLYCEVLS LDFWQRYRVE GYGAVVLPAT PGSHTLTVST WRPVELGTVA 
    ELRRFFIGGS LELEDLSYVR IPGSFKGERL SRFGLRTETT GTVTFRLHCL QQSRAFMESS 
    SLQKRMRSVL DRLEGFSQQS SIHNVLEAFR RARRRMQEAR ESLPQDLVSP SGTLVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.