CYP2W1 | ENSG00000073067 | NCBI 54905

Details for: CYP2W1

Gene ID: 54905

Symbol: CYP2W1

Ensembl ID: ENSG00000073067

Description: cytochrome P450 family 2 subfamily W member 1

Associated with

Biological oxidations
(R-HSA-211859)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Metabolism
(R-HSA-1430728)
Miscellaneous substrates
(R-HSA-211958)
Phase i - functionalization of compounds
(R-HSA-211945)
Xenobiotics
(R-HSA-211981)
Aflatoxin metabolic process
(GO:0046222)
All-trans-retinol binding
(GO:1904768)
All-trans retinal binding
(GO:0005503)
Cell surface
(GO:0009986)
Cytochrome metabolic process
(GO:1903604)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum lumen
(GO:0005788)
Endoplasmic reticulum membrane
(GO:0005789)
Heme binding
(GO:0020037)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Monooxygenase activity
(GO:0004497)
Organic acid metabolic process
(GO:0006082)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Phospholipid metabolic process
(GO:0006644)
Plasma membrane
(GO:0005886)
Retinoic acid 4-hydroxylase activity
(GO:0008401)
Retinoic acid binding
(GO:0001972)
Retinoic acid catabolic process
(GO:0034653)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

CYPIIW1

Genular Protein ID: 1007292622

Symbol: CP2W1_HUMAN

Name: CYPIIW1

UniProtKB Accession Codes:

Q8TAV3

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 16426568

Title: Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1.

PubMed ID: 16426568

DOI: 10.1016/j.bbrc.2005.12.200

PubMed ID: 16551781

Title: Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1.

PubMed ID: 16551781

DOI: 10.1124/mol.106.023648

PubMed ID: 20805301

Title: Colorectal cancer-specific cytochrome P450 2W1: intracellular localization, glycosylation, and catalytic activity.

PubMed ID: 20805301

DOI: 10.1124/mol.110.067652

PubMed ID: 24278521

Title: Bioactivation of aromatic amines by human CYP2W1, an orphan cytochrome P450 enzyme.

PubMed ID: 24278521

DOI: 10.5487/tr.2010.26.3.171

PubMed ID: 22591743

Title: Metabolomic analysis and identification of a role for the orphan human cytochrome P450 2W1 in selective oxidation of lysophospholipids.

PubMed ID: 22591743

DOI: 10.1194/jlr.m027185

PubMed ID: 26936974

Title: Catalytic Activities of Tumor-Specific Human Cytochrome P450 CYP2W1 Toward Endogenous Substrates.

PubMed ID: 26936974

DOI: 10.1124/dmd.116.069633

PubMed ID: 20602611

Title: CYP2W1 variant alleles in Caucasians and association of the CYP2W1 G541A (Ala181Thr) polymorphism with increased colorectal cancer risk.

PubMed ID: 20602611

DOI: 10.2217/pgs.10.66

Sequence Information:

Length: 490
Mass: 53844
Checksum: BB84B2F1FEFEF5BC
Sequence:

MALLLLLFLG LLGLWGLLCA CAQDPSPAAR WPPGPRPLPL VGNLHLLRLS QQDRSLMELS 
ERYGPVFTVH LGRQKTVVLT GFEAVKEALA GPGQELADRP PIAIFQLIQR GGGIFFSSGA 
RWRAARQFTV RALHSLGVGR EPVADKILQE LKCLSGQLDG YRGRPFPLAL LGWAPSNITF 
ALLFGRRFDY RDPVFVSLLG LIDEVMVLLG SPGLQLFNVY PWLGALLQLH RPVLRKIEEV 
RAILRTLLEA RRPHVCPGDP VCSYVDALIQ QGQGDDPEGL FAEANAVACT LDMVMAGTET 
TSATLQWAAL LMGRHPDVQG RVQEELDRVL GPGRTPRLED QQALPYTSAV LHEVQRFITL 
LPHVPRCTAA DTQLGGFLLP KGTPVIPLLT SVLLDETQWQ TPGQFNPGHF LDANGHFVKR 
EAFLPFSAGR RVCVGERLAR TELFLLFAGL LQRYRLLPPP GVSPASLDTT PARAFTMRPR 
AQALCAVPRP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CYP2W1

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The DNA sequence of human chromosome 7. PubMed ID: 12853948

Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1. PubMed ID: 16426568

Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. PubMed ID: 16551781

Colorectal cancer-specific cytochrome P450 2W1: intracellular localization, glycosylation, and catalytic activity. PubMed ID: 20805301

Bioactivation of aromatic amines by human CYP2W1, an orphan cytochrome P450 enzyme. PubMed ID: 24278521

Metabolomic analysis and identification of a role for the orphan human cytochrome P450 2W1 in selective oxidation of lysophospholipids. PubMed ID: 22591743

Catalytic Activities of Tumor-Specific Human Cytochrome P450 CYP2W1 Toward Endogenous Substrates. PubMed ID: 26936974

CYP2W1 variant alleles in Caucasians and association of the CYP2W1 G541A (Ala181Thr) polymorphism with increased colorectal cancer risk. PubMed ID: 20602611