SPDL1 | ENSG00000040275 | NCBI 54908

Details for: SPDL1

Gene ID: 54908

Symbol: SPDL1

Ensembl ID: ENSG00000040275

Description: spindle apparatus coiled-coil protein 1

Associated with

Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Cell division
(GO:0051301)
Cell migration
(GO:0016477)
Centrosome
(GO:0005813)
Cytosol
(GO:0005829)
Enzyme binding
(GO:0019899)
Establishment of mitotic spindle orientation
(GO:0000132)
Kinetochore binding
(GO:0043515)
Mitotic metaphase chromosome alignment
(GO:0007080)
Mitotic spindle assembly checkpoint signaling
(GO:0007094)
Nucleus
(GO:0005634)
Outer kinetochore
(GO:0000940)
Protein binding
(GO:0005515)
Protein localization to kinetochore
(GO:0034501)
Spindle pole
(GO:0000922)

Other Information

Proteins

Arsenite-related gene 1 protein

Genular Protein ID: 1752841949

Symbol: SPDLY_HUMAN

Name: Arsenite-related gene 1 protein

UniProtKB Accession Codes:

Q96EA4 B4E393 C9JS47 Q8TEC8 Q9HD44 Q9NX97

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17576797

Title: Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore.

PubMed ID: 17576797

DOI: 10.1083/jcb.200702062

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19468067

Title: Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly.

PubMed ID: 19468067

DOI: 10.1083/jcb.200812167

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25035494

Title: Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes.

PubMed ID: 25035494

DOI: 10.1126/science.1254198

PubMed ID: 30258100

Title: USP45 and Spindly are part of the same complex implicated in cell migration.

PubMed ID: 30258100

DOI: 10.1038/s41598-018-32685-8

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

Length: 605
Mass: 70172
Checksum: 1F8D38C9261D6605
Sequence:

MEADIITNLR CRLKEAEEER LKAAQYGLQL VESQNELQNQ LDKCRNEMMT MTESYEQEKY 
TLQREVELKS RMLESLSCEC EAIKQQQKMH LEKLEEQLSR SHGQEVNELK TKIEKLKVEL 
DEARLSEKQL KHQVDHQKEL LSCKSEELRV MSERVQESMS SEMLALQIEL TEMESMKTTL 
KEEVNELQYR QEQLELLITN LMRQVDRLKE EKEEREKEAV SYYNALEKAR VANQDLQVQL 
DQALQQALDP NSKGNSLFAE VEDRRAAMER QLISMKVKYQ SLKKQNVFNR EQMQRMKLQI 
ATLLQMKGSQ TEFEQQERLL AMLEQKNGEI KHLLGEIRNL EKFKNLYDSM ESKPSVDSGT 
LEDNTYYTDL LQMKLDNLNK EIESTKGELS IQRMKALFES QRALDIERKL FANERCLQLS 
ESENMKLRAK LDELKLKYEP EETVEVPVLK KRREVLPVDI TTAKDACVNN SALGGEVYRL 
PPQKEETQSC PNSLEDNNLQ LEKSVSIYTP VVSLSPHKNL PVDMQLKKEK KCVKLIGVPA 
DAEALSERSG NTPNSPRLAA ESKLQTEVKE GKETSSKLEK ETCKKLHPIL YVSSKSTPET 
QCPQQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SPDL1

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore. PubMed ID: 17576797

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. PubMed ID: 19468067

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. PubMed ID: 25035494

USP45 and Spindly are part of the same complex implicated in cell migration. PubMed ID: 30258100

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. PubMed ID: 17924679

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692