Details for: YTHDF1

Gene ID: 54915

Symbol: YTHDF1

Ensembl ID: ENSG00000149658

Description: YTH N6-methyladenosine RNA binding protein F1

Associated with

Other Information

Genular Protein ID: 2246595777

Symbol: YTHD1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BYJ9 Q8N3G5 Q8TBT1 Q96AN4 Q96S57 Q9BTI7 Q9NX79

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 9 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24284625

Title: N-methyladenosine-dependent regulation of messenger RNA stability.

PubMed ID: 24284625

DOI: 10.1038/nature12730

PubMed ID: 26046440

Title: N(6)-methyladenosine modulates messenger RNA translation efficiency.

PubMed ID: 26046440

DOI: 10.1016/j.cell.2015.05.014

PubMed ID: 26593424

Title: 5' UTR m(6)A promotes cap-independent translation.

PubMed ID: 26593424

DOI: 10.1016/j.cell.2015.10.012

PubMed ID: 28106072

Title: YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA.

PubMed ID: 28106072

DOI: 10.1038/cr.2017.15

PubMed ID: 31388144

Title: Multivalent m6A motifs promote phase separation of YTHDF proteins.

PubMed ID: 31388144

DOI: 10.1038/s41422-019-0210-3

PubMed ID: 31292544

Title: m6A enhances the phase separation potential of mRNA.

PubMed ID: 31292544

DOI: 10.1038/s41586-019-1374-1

PubMed ID: 32492408

Title: A unified model for the function of YTHDF proteins in regulating m6A-modified mRNA.

PubMed ID: 32492408

DOI: 10.1016/j.cell.2020.05.012

PubMed ID: 32451507

Title: m6A-binding YTHDF proteins promote stress granule formation.

PubMed ID: 32451507

DOI: 10.1038/s41589-020-0524-y

PubMed ID: 26318451

Title: structural basis for the discriminative recognition of N6-methyladenosine RNA by the human YT521-B homology domain family of proteins.

PubMed ID: 26318451

DOI: 10.1074/jbc.m115.680389

Sequence Information:

  • Length: 559
  • Mass: 60874
  • Checksum: DB8AA15636130E18
  • Sequence:
    • MSATSVDTQR TKGQDNKVQN GSLHQKDTVH DNDFEPYLTG QSNQSNSYPS MSDPYLSSYY 
PPSIGFPYSL NEAPWSTAGD PPIPYLTTYG QLSNGDHHFM HDAVFGQPGG LGNNIYQHRF 
NFFPENPAFS AWGTSGSQGQ QTQSSAYGSS YTYPPSSLGG TVVDGQPGFH SDTLSKAPGM 
NSLEQGMVGL KIGDVSSSAV KTVGSVVSSV ALTGVLSGNG GTNVNMPVSK PTSWAAIASK 
PAKPQPKMKT KSGPVMGGGL PPPPIKHNMD IGTWDNKGPV PKAPVPQQAP SPQAAPQPQQ 
VAQPLPAQPP ALAQPQYQSP QQPPQTRWVA PRNRNAAFGQ SGGAGSDSNS PGNVQPNSAP 
SVESHPVLEK LKAAHSYNPK EFEWNLKSGR VFIIKSYSED DIHRSIKYSI WCSTEHGNKR 
LDSAFRCMSS KGPVYLLFSV NGSGHFCGVA EMKSPVDYGT SAGVWSQDKW KGKFDVQWIF 
VKDVPNNQLR HIRLENNDNK PVTNSRDTQE VPLEKAKQVL KIISSYKHTT SIFDDFAHYE 
KRQEEEEVVR KERQSRNKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.