Details for: RNF125

Gene ID: 54941

Symbol: RNF125

Ensembl ID: ENSG00000101695

Description: ring finger protein 125

Associated with

Other Information

Genular Protein ID: 4024730702

Symbol: RN125_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96EQ8 Q9NX39

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 ELM 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12974981

Title: Systematic identification of regulatory proteins critical for T-cell activation.

PubMed ID: 12974981

DOI: 10.1186/1475-4924-2-21

PubMed ID: 15843525

Title: A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation.

PubMed ID: 15843525

DOI: 10.4049/jimmunol.174.9.5288

PubMed ID: 17460044

Title: Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.

PubMed ID: 17460044

DOI: 10.1073/pnas.0611551104

PubMed ID: 17643463

Title: The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells.

PubMed ID: 17643463

DOI: 10.1016/j.virol.2007.06.028

PubMed ID: 17990982

Title: T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain.

PubMed ID: 17990982

DOI: 10.1042/bj20070995

PubMed ID: 25196541

Title: A new overgrowth syndrome is due to mutations in RNF125.

PubMed ID: 25196541

DOI: 10.1002/humu.22689

PubMed ID: 25591766

Title: RNF125 is a ubiquitin-protein ligase that promotes p53 degradation.

PubMed ID: 25591766

DOI: 10.1159/000369691

PubMed ID: 26027934

Title: Downregulation of the ubiquitin ligase RNF125 underlies resistance of melanoma cells to BRAF inhibitors via JAK1 deregulation.

PubMed ID: 26027934

DOI: 10.1016/j.celrep.2015.04.049

PubMed ID: 26471729

Title: A non-canonical role of the p97 complex in RIG-I antiviral signaling.

PubMed ID: 26471729

DOI: 10.15252/embj.201591888

PubMed ID: 26202983

Title: MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125.

PubMed ID: 26202983

DOI: 10.4049/jimmunol.1500370

PubMed ID: 27411375

Title: A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125.

PubMed ID: 27411375

DOI: 10.1038/srep29232

Sequence Information:

  • Length: 232
  • Mass: 26454
  • Checksum: E3D93D546AD99D81
  • Sequence:
    • MGSVLSTDSG KSAPASATAR ALERRRDPEL PVTSFDCAVC LEVLHQPVRT RCGHVFCRSC 
IATSLKNNKW TCPYCRAYLP SEGVPATDVA KRMKSEYKNC AECDTLVCLS EMRAHIRTCQ 
KYIDKYGPLQ ELEETAARCV CPFCQRELYE DSLLDHCITH HRSERRPVFC PLCRLIPDEN 
PSSFSGSLIR HLQVSHTLFY DDFIDFNIIE EALIRRVLDR SLLEYVNHSN TT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.