Details for: HPF1
Associated with
Other Information
Genular Protein ID: 1031277791
Symbol: HPF1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 27067600
Title: HPF1/C4orf27 is a PARP-1-interacting protein that regulates PARP-1 ADP-ribosylation activity.
PubMed ID: 27067600
PubMed ID: 28190768
Title: Serine ADP-ribosylation depends on HPF1.
PubMed ID: 28190768
PubMed ID: 30257210
Title: Interplay of histone marks with serine ADP-ribosylation.
PubMed ID: 30257210
PubMed ID: 29480802
Title: Serine is the major residue for ADP-ribosylation upon DNA damage.
PubMed ID: 29480802
DOI: 10.7554/elife.34334
PubMed ID: 29954836
Title: Comprehensive ADP-ribosylome analysis identifies tyrosine as an ADP-ribose acceptor site.
PubMed ID: 29954836
PubMed ID: 33186521
Title: An HPF1/PARP1-based chemical biology strategy for exploring ADP-ribosylation.
PubMed ID: 33186521
PubMed ID: 33141820
Title: Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1.
PubMed ID: 33141820
PubMed ID: 34732825
Title: Dual function of HPF1 in the modulation of PARP1 and PARP2 activities.
PubMed ID: 34732825
PubMed ID: 33683197
Title: HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase.
PubMed ID: 33683197
DOI: 10.7554/elife.65773
PubMed ID: 34486521
Title: Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome.
PubMed ID: 34486521
DOI: 10.7554/elife.71420
PubMed ID: 34874266
Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.
PubMed ID: 34874266
DOI: 10.7554/elife.71502
PubMed ID: 34108479
Title: Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition.
PubMed ID: 34108479
PubMed ID: 34210965
Title: Serine-linked PARP1 auto-modification controls PARP inhibitor response.
PubMed ID: 34210965
PubMed ID: 34625544
Title: The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome.
PubMed ID: 34625544
PubMed ID: 34795260
Title: HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications.
PubMed ID: 34795260
PubMed ID: 32028527
Title: HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
PubMed ID: 32028527
PubMed ID: 32939087
Title: Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin.
PubMed ID: 32939087
PubMed ID: 33589610
Title: HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones.
PubMed ID: 33589610
Sequence Information:
- Length: 346
- Mass: 39436
- Checksum: DF411C9AE254E1E1
- Sequence:
MVGGGGKRRP GGEGPQCEKT TDVKKSKFCE ADVSSDLRKE VENHYKLSLP EDFYHFWKFC EELDPEKPSD SLSASLGLQL VGPYDILAGK HKTKKKSTGL NFNLHWRFYY DPPEFQTIII GDNKTQYHMG YFRDSPDEFP VYVGINEAKK NCIIVPNGDN VFAAVKLFLT KKLREITDKK KINLLKNIDE KLTEAARELG YSLEQRTVKM KQRDKKVVTK TFHGAGLVVP VDKNDVGYRE LPETDADLKR ICKTIVEAAS DEERLKAFAP IQEMMTFVQF ANDECDYGMG LELGMDLFCY GSHYFHKVAG QLLPLAYNLL KRNLFAEIIE EHLANRSQEN IDQLAA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.