Details for: HPF1

Gene ID: 54969

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: HPF1

Ensembl ID: ENSG00000056050

Description: histone PARylation factor 1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • lung neuroendocrine cell CL1000223
    CSI 9.91
    rCSI 14.66%
    PRS 59.25
  • tracheobronchial smooth muscle cell CL0019019
    CSI 7.18
    rCSI 12.67%
    PRS 62.19
  • double negative thymocyte CL0002489
    CSI 6.32
    rCSI 4.39%
    PRS 64.13
  • erythrocyte CL0000232
    CSI 5.62
    rCSI 12.74%
    PRS 59
  • epithelial cell of lower respiratory tract CL0002632
    CSI 4.99
    rCSI 3.87%
    PRS 55.01
  • skin fibroblast CL0002620
    CSI 4.9
    rCSI 4.22%
    PRS 60.84
  • epithelial cell of lung CL0000082
    CSI 4.77
    rCSI 3.95%
    PRS 52.82
  • VIP GABAergic cortical interneuron CL4023016
    CSI 4.68
    rCSI 5.59%
    PRS 36.42
  • forebrain radial glial cell CL0013000
    CSI 4.53
    rCSI 14.53%
    PRS 60.18
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 4.33
    rCSI 12.79%
    PRS 57.64
  • retina horizontal cell CL0000745
    CSI 4.33
    rCSI 6.6%
    PRS 50.33
  • mature alpha-beta T cell CL0000791
    CSI 4.32
    rCSI 15.63%
    PRS 73.67
  • radial glial cell CL0000681
    CSI 4.05
    rCSI 5.63%
    PRS 53.06
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 4.04
    rCSI 4.67%
    PRS 47.65
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 3.93
    rCSI 2.99%
    PRS 66.51
  • extravillous trophoblast CL0008036
    CSI 3.87
    rCSI 4.79%
    PRS 49.81
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 3.75
    rCSI 6.62%
    PRS 35.63
  • myoepithelial cell CL0000185
    CSI 3.74
    rCSI 9.47%
    PRS 62.29
  • bronchus fibroblast of lung CL2000093
    CSI 3.67
    rCSI 2.98%
    PRS 54.35
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 3.57
    rCSI 4.58%
    PRS 51.59
  • perivascular cell CL4033054
    CSI 3.48
    rCSI 4.76%
    PRS 59.46
  • glutamatergic neuron CL0000679
    CSI 3.39
    rCSI 6.96%
    PRS 45.53
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 3.09
    rCSI 3.03%
    PRS 69.76
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.92
    rCSI 3.63%
    PRS 34.86
  • ionocyte CL0005006
    CSI 2.87
    rCSI 3.08%
    PRS 52.54
  • myofibroblast cell CL0000186
    CSI 2.77
    rCSI 3.83%
    PRS 56.68
  • interneuron CL0000099
    CSI 2.66
    rCSI 5.33%
    PRS 43.17
  • hematopoietic precursor cell CL0008001
    CSI 2.61
    rCSI 2.69%
    PRS 71.8
  • pancreatic D cell CL0000173
    CSI 2.57
    rCSI 2.53%
    PRS 56.4
  • interstitial cell of Cajal CL0002088
    CSI 2.48
    rCSI 3.16%
    PRS 60.25
  • ON-bipolar cell CL0000749
    CSI 2.44
    rCSI 3.62%
    PRS 56.13
  • neural crest cell CL0011012
    CSI 2.35
    rCSI 1.86%
    PRS 40.98
  • primitive red blood cell CL0002355
    CSI 2.31
    rCSI 12.48%
    PRS 67.9
  • acinar cell CL0000622
    CSI 2.26
    rCSI 3.31%
    PRS 65.58
  • cerebellar granule cell CL0001031
    CSI 2.25
    rCSI 3.31%
    PRS 48.02
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 2.22
    rCSI 2.27%
    PRS 67.45
  • fraction A pre-pro B cell CL0002045
    CSI 2.21
    rCSI 2.53%
    PRS 75.03
  • pro-B cell CL0000826
    CSI 2.16
    rCSI 1.79%
    PRS 55.52
  • early lymphoid progenitor CL0000936
    CSI 2.14
    rCSI 1.88%
    PRS 59.2
  • peripheral nervous system neuron CL2000032
    CSI 2.13
    rCSI 2.9%
    PRS 46.44
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 2.12
    rCSI 1.91%
    PRS 50.72
  • fibroblast of lung CL0002553
    CSI 2.11
    rCSI 1.96%
    PRS 53.66
  • conjunctival epithelial cell CL1000432
    CSI 2.07
    rCSI 3.17%
    PRS 54.48
  • hematopoietic stem cell CL0000037
    CSI 2.07
    rCSI 1.37%
    PRS 57.49
  • retinal rod cell CL0000604
    CSI 1.95
    rCSI 3.44%
    PRS 51.28
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.95
    rCSI 1.5%
    PRS 53.48
  • choroid plexus epithelial cell CL0000706
    CSI 1.92
    rCSI 3.15%
    PRS 43.61
  • microcirculation associated smooth muscle cell CL0008035
    CSI 1.86
    rCSI 5.38%
    PRS 55.78
  • intermediate monocyte CL0002393
    CSI 1.78
    rCSI 2.69%
    PRS 56.99
  • Mueller cell CL0000636
    CSI 1.74
    rCSI 3.98%
    PRS 46.15
  • myeloid leukocyte CL0000766
    CSI 1.73
    rCSI 1.6%
    PRS 55.04
  • pulmonary ionocyte CL0017000
    CSI 1.73
    rCSI 2.1%
    PRS 61.77
  • vascular associated smooth muscle cell CL0000359
    CSI 1.72
    rCSI 5.57%
    PRS 55.59
  • keratinocyte CL0000312
    CSI 1.7
    rCSI 1.42%
    PRS 58.72
  • alveolar adventitial fibroblast CL4028006
    CSI 1.69
    rCSI 2.68%
    PRS 55.41
  • rod bipolar cell CL0000751
    CSI 1.69
    rCSI 3.04%
    PRS 47.06
  • promonocyte CL0000559
    CSI 1.67
    rCSI 2.87%
    PRS 63.37
  • transit amplifying cell of colon CL0009011
    CSI 1.67
    rCSI 1.96%
    PRS 57.02
  • stem cell CL0000034
    CSI 1.66
    rCSI 1.6%
    PRS 44.48
  • cardiac muscle cell CL0000746
    CSI 1.65
    rCSI 2.37%
    PRS 44.09
  • sst GABAergic cortical interneuron CL4023017
    CSI 1.65
    rCSI 2.13%
    PRS 37.7
  • ciliated epithelial cell CL0000067
    CSI 1.65
    rCSI 1.45%
    PRS 42.33
  • retinal bipolar neuron CL0000748
    CSI 1.61
    rCSI 3.02%
    PRS 42.69
  • lung macrophage CL1001603
    CSI 1.61
    rCSI 3.58%
    PRS 61.27
  • placental villous trophoblast CL2000060
    CSI 1.57
    rCSI 2.42%
    PRS 51.94
  • enteric smooth muscle cell CL0002504
    CSI 1.55
    rCSI 2.21%
    PRS 56.45
  • dendritic cell, human CL0001056
    CSI 1.53
    rCSI 2.35%
    PRS 62.14
  • mesenchymal cell CL0008019
    CSI 1.51
    rCSI 3.83%
    PRS 48.88
  • OFF-bipolar cell CL0000750
    CSI 1.48
    rCSI 2.02%
    PRS 62.34
  • hepatocyte CL0000182
    CSI 1.47
    rCSI 2.63%
    PRS 52.55
  • retinal blood vessel endothelial cell CL0002585
    CSI 1.46
    rCSI 2.34%
    PRS 57.66
  • promyelocyte CL0000836
    CSI 1.44
    rCSI 2.08%
    PRS 63.63
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 1.39
    rCSI 1.9%
    PRS 74.17
  • glioblast CL0000030
    CSI 1.34
    rCSI 2.14%
    PRS 47.06
  • mesodermal cell CL0000222
    CSI 1.32
    rCSI 1.59%
    PRS 52.08
  • retinal cone cell CL0000573
    CSI 1.32
    rCSI 2.12%
    PRS 43.88
  • club cell CL0000158
    CSI 1.3
    rCSI 1.91%
    PRS 51.47
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 1.28
    rCSI 3.07%
    PRS 72.5
  • lung pericyte CL0009089
    CSI 1.24
    rCSI 3.28%
    PRS 62.32
  • pancreatic ductal cell CL0002079
    CSI 1.18
    rCSI 2.3%
    PRS 56.5
  • common dendritic progenitor CL0001029
    CSI 1.18
    rCSI 1.48%
    PRS 64.25
  • neural progenitor cell CL0011020
    CSI 1.07
    rCSI 4.72%
    PRS 45.56
  • lung ciliated cell CL1000271
    CSI 1.04
    rCSI 1.2%
    PRS 43.86
  • pluripotent stem cell CL0002248
    CSI 1.03
    rCSI 31.04%
    PRS 75.69
  • progenitor cell CL0011026
    CSI 0.97
    rCSI 2.07%
    PRS 55.3
  • retinal ganglion cell CL0000740
    CSI 0.92
    rCSI 2.03%
    PRS 40.89
  • type B pancreatic cell CL0000169
    CSI 0.91
    rCSI 2.02%
    PRS 51.63
  • stromal cell of ovary CL0002132
    CSI 0.89
    rCSI 2.45%
    PRS 68.04
  • amacrine cell CL0000561
    CSI 0.83
    rCSI 2.42%
    PRS 44.11
  • primordial germ cell CL0000670
    CSI 0.83
    rCSI 4.17%
    PRS 87.78
  • pancreatic stellate cell CL0002410
    CSI 0.75
    rCSI 4.34%
    PRS 63.89
  • podocyte CL0000653
    CSI 0.72
    rCSI 3.2%
    PRS 52.97
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 0.6
    rCSI 3.09%
    PRS 76.9
  • endothelial cell of placenta CL0009092
    CSI 0.58
    rCSI 2.88%
    PRS 65.26
  • Hofbauer cell CL3000001
    CSI 0.57
    rCSI 1.08%
    PRS 64.34
  • transit amplifying cell of small intestine CL0009012
    CSI 0.55
    rCSI 2.43%
    PRS 70.67
  • Cajal-Retzius cell CL0000695
    CSI 0.46
    rCSI 3.62%
    PRS 67.8

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary Histone PARylation factor 1, encoded by the [HPF1](/details-gene/54969) gene, is a crucial nuclear protein that functions as a key regulator of the DNA damage response. It acts as an adaptor protein that specifically interacts with PARP-1 and PARP-2, modifying their enzymatic activity to promote serine ADP-ribosylation at sites of DNA damage ([Link](https://doi.org/10.1016/j.molcel.2016.03.008), [Link](https://doi.org/10.1016/j.molcel.2017.01.003)). The expression profile of [HPF1](/details-gene/54969) is widespread, with notable significance in diverse cell types including [lung neuroendocrine cell](/details-cell/CL1000223), [tracheobronchial smooth muscle cell](/details-cell/CL0019019), and various immune and neural progenitors. This broad expression underscores its fundamental role in maintaining genomic integrity across multiple tissues. ## Cellular Roles and Expression Landscape **Overall**, the expression pattern of [HPF1](/details-gene/54969) suggests a ubiquitous and essential role in cellular homeostasis rather than a function restricted to a specific lineage. Its high significance is observed in a functionally diverse set of cells. The highest cell significance index (CSI) is found in [lung neuroendocrine cell](/details-cell/CL1000223) (CSI: 9.91), followed by [tracheobronchial smooth muscle cell](/details-cell/CL0019019) (CSI: 7.18), indicating a strong role in these specialized and structural cell types. Furthermore, [HPF1](/details-gene/54969) is significantly expressed in various cells of the immune system, including [double negative thymocyte](/details-cell/CL0002489) (CSI: 6.32), [mature alpha-beta T cell](/details-cell/CL0000791) (CSI: 4.32), and [effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050) (CSI: 3.93). Its presence in progenitor and developing cells, such as [forebrain radial glial cell](/details-cell/CL0013000) (CSI: 4.53) and [neuroblast (sensu Nematoda and Protostomia)](/details-cell/CL0000338) (CSI: 4.04), is consistent with its critical function in safeguarding the genome during cell division and differentiation. The broad distribution across ectodermal, mesodermal, and endodermal derivatives highlights its housekeeping-like importance in the DNA damage response pathway. ## Pathways and Molecular Function The functional annotations for [HPF1](/details-gene/54969) are highly consistent with its established role as a central component of the DNA repair machinery. It is primarily involved in the biological processes of [Dna damage response](/details-gene/GO:0006974) and [Dna repair](/details-gene/GO:0006281), with specific roles in [Double-strand break repair](/details-gene/GO:0006302) and [Dna repair-dependent chromatin remodeling](/details-gene/GO:0140861). The gene product localizes to the [Nucleus](/details-gene/GO:0005634), where it binds to [Chromatin](/details-gene/GO:0000785) and is recruited to the [Site of dna damage](/details-gene/GO:0090734). At the molecular level, [HPF1](/details-gene/54969) functions as a [Protein adp-ribosyltransferase-substrate adaptor activity](/details-gene/GO:0140768). It does not possess intrinsic enzymatic activity but rather binds to PARP-1 and PARP-2 to switch their substrate specificity from aspartate/glutamate residues to serine residues upon DNA damage ([Link](https://doi.org/10.1016/j.molcel.2017.01.003), [Link](https://doi.org/10.7554/elife.34334)). This redirection of PARP activity is a critical step in the signaling cascade that coordinates the recruitment of downstream repair factors. This function is supported by its annotated abilities in [Histone binding](/details-gene/GO:0042393) and general [Protein binding](/details-gene/GO:0005515), which facilitate its interaction with both the chromatin substrate and the PARP enzymes. ## Research Directions Given the central role of [HPF1](/details-gene/54969) in modulating PARP-1/2 activity, a key enzyme family targeted in cancer therapy, its expression and function have significant clinical implications. Its widespread expression suggests that its dysregulation could impact a broad range of tissues and pathologies. Based on the available data, several testable hypotheses can be proposed: 1. The expression level of [HPF1](/details-gene/54969) in tumor cells may serve as a predictive biomarker for sensitivity to PARP inhibitors (PARPi). Cancers with low or absent [HPF1](/details-gene/54969) may exhibit a distinct response profile to PARPi, as the primary mode of PARP-dependent signaling (serine ADP-ribosylation) would be compromised, potentially leading to intrinsic resistance or reliance on alternative DNA repair pathways. 2. In the context of neurodegenerative diseases characterized by accumulating DNA damage, variations in [HPF1](/details-gene/54969) expression or function could contribute to neuronal vulnerability. Its high significance in neural cell types like [VIP GABAergic cortical interneuron](/details-cell/CL4023016) suggests that maintaining its activity is critical for neuronal survival, and its decline with age could exacerbate pathology. **Experimental Approach to Test Hypothesis 1:** To investigate the role of [HPF1](/details-gene/54969) in PARPi sensitivity, a systematic study using cancer cell lines could be performed. First, establish a panel of cell lines (e.g., from breast, ovarian, and prostate cancers) and quantify their endogenous [HPF1](/details-gene/54969) protein levels. Using CRISPR-Cas9, generate isogenic cell lines with [HPF1](/details-gene/54969) knocked out. Both the parental and knockout cell lines would then be treated with a dose-response matrix of different PARP inhibitors (e.g., Olaparib, Talazoparib). Cell viability assays (e.g., MTT or clonogenic survival assays) would quantify drug sensitivity. Mechanistically, the cellular response to DNA damage (e.g., ionizing radiation) in the presence and absence of PARPi could be assessed by measuring markers like γH2AX foci formation and the efficiency of DNA repair via immunofluorescence and comet assays. A finding that [HPF1](/details-gene/54969)-deficient cells are more resistant to PARPi would establish its potential as a critical biomarker for patient stratification. **Therapeutic Potential:** As a non-enzymatic adaptor protein, [HPF1](/details-gene/54969) presents a challenging but potentially valuable therapeutic target. The strategy would likely be **inhibition** of its interaction with PARP-1/2. Developing small molecules or peptidomimetics that disrupt the HPF1-PARP1 protein-protein interface could be a novel way to modulate the DNA damage response. Such an inhibitor could be used to sensitize tumors to specific DNA-damaging agents or, conversely, to protect healthy tissues from genotoxic stress. However, given the gene's broad expression and fundamental role, systemic inhibition would carry a high risk of on-target toxicity. Therefore, therapeutic development would likely require sophisticated, tumor-targeted delivery systems to be clinically viable.

Genular Protein ID: 1031277791

Symbol: HPF1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NWY4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 3 Ensembl 1 GO 12 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 27067600

Title: HPF1/C4orf27 is a PARP-1-interacting protein that regulates PARP-1 ADP-ribosylation activity.

PubMed ID: 27067600

DOI: 10.1016/j.molcel.2016.03.008

PubMed ID: 28190768

Title: Serine ADP-ribosylation depends on HPF1.

PubMed ID: 28190768

DOI: 10.1016/j.molcel.2017.01.003

PubMed ID: 30257210

Title: Interplay of histone marks with serine ADP-ribosylation.

PubMed ID: 30257210

DOI: 10.1016/j.celrep.2018.08.092

PubMed ID: 29480802

Title: Serine is the major residue for ADP-ribosylation upon DNA damage.

PubMed ID: 29480802

DOI: 10.7554/elife.34334

PubMed ID: 29954836

Title: Comprehensive ADP-ribosylome analysis identifies tyrosine as an ADP-ribose acceptor site.

PubMed ID: 29954836

DOI: 10.15252/embr.201745310

PubMed ID: 33186521

Title: An HPF1/PARP1-based chemical biology strategy for exploring ADP-ribosylation.

PubMed ID: 33186521

DOI: 10.1016/j.cell.2020.09.055

PubMed ID: 33141820

Title: Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1.

PubMed ID: 33141820

DOI: 10.1371/journal.pone.0240932

PubMed ID: 34732825

Title: Dual function of HPF1 in the modulation of PARP1 and PARP2 activities.

PubMed ID: 34732825

DOI: 10.1038/s42003-021-02780-0

PubMed ID: 33683197

Title: HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase.

PubMed ID: 33683197

DOI: 10.7554/elife.65773

PubMed ID: 34486521

Title: Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome.

PubMed ID: 34486521

DOI: 10.7554/elife.71420

PubMed ID: 34874266

Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.

PubMed ID: 34874266

DOI: 10.7554/elife.71502

PubMed ID: 34108479

Title: Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition.

PubMed ID: 34108479

DOI: 10.1038/s41467-021-23800-x

PubMed ID: 34210965

Title: Serine-linked PARP1 auto-modification controls PARP inhibitor response.

PubMed ID: 34210965

DOI: 10.1038/s41467-021-24361-9

PubMed ID: 34625544

Title: The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome.

PubMed ID: 34625544

DOI: 10.1038/s41467-021-26172-4

PubMed ID: 34795260

Title: HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications.

PubMed ID: 34795260

DOI: 10.1038/s41467-021-27043-8

PubMed ID: 32028527

Title: HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.

PubMed ID: 32028527

DOI: 10.1038/s41586-020-2013-6

PubMed ID: 32939087

Title: Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin.

PubMed ID: 32939087

DOI: 10.1038/s41586-020-2725-7

PubMed ID: 33589610

Title: HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones.

PubMed ID: 33589610

DOI: 10.1038/s41467-021-21302-4

Sequence Information:

  • Length: 346
  • Mass: 39436
  • Checksum: DF411C9AE254E1E1
  • Sequence:
    • MVGGGGKRRP GGEGPQCEKT TDVKKSKFCE ADVSSDLRKE VENHYKLSLP EDFYHFWKFC 
EELDPEKPSD SLSASLGLQL VGPYDILAGK HKTKKKSTGL NFNLHWRFYY DPPEFQTIII 
GDNKTQYHMG YFRDSPDEFP VYVGINEAKK NCIIVPNGDN VFAAVKLFLT KKLREITDKK 
KINLLKNIDE KLTEAARELG YSLEQRTVKM KQRDKKVVTK TFHGAGLVVP VDKNDVGYRE 
LPETDADLKR ICKTIVEAAS DEERLKAFAP IQEMMTFVQF ANDECDYGMG LELGMDLFCY 
GSHYFHKVAG QLLPLAYNLL KRNLFAEIIE EHLANRSQEN IDQLAA