Details for: PINX1

Gene ID: 54984

Symbol: PINX1

Ensembl ID: ENSG00000254093

Description: PIN2 (TERF1) interacting telomerase inhibitor 1

Associated with

Other Information

Genular Protein ID: 4227668615

Symbol: PINX1_HUMAN

Name: PIN2/TERF1-interacting telomerase inhibitor 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11003615

Title: Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma.

PubMed ID: 11003615

DOI: 10.1053/jhep.2000.17967

PubMed ID: 11701125

Title: The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor.

PubMed ID: 11701125

DOI: 10.1016/s0092-8674(01)00538-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15044100

Title: Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length.

PubMed ID: 15044100

DOI: 10.1016/j.bbrc.2004.02.166

PubMed ID: 15381700

Title: Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR.

PubMed ID: 15381700

DOI: 10.1074/jbc.m408131200

PubMed ID: 17198684

Title: Characterization of a novel effect of hPinX1 on hTERT nucleolar localization.

PubMed ID: 17198684

DOI: 10.1016/j.bbrc.2006.12.123

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18202258

Title: A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.

PubMed ID: 18202258

DOI: 10.1126/science.1151804

PubMed ID: 19393617

Title: PinX1 is recruited to the mitotic chromosome periphery by nucleolin and facilitates chromosome congression.

PubMed ID: 19393617

DOI: 10.1016/j.bbrc.2009.04.077

PubMed ID: 19117989

Title: Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells.

PubMed ID: 19117989

DOI: 10.1158/0008-5472.can-08-1393

PubMed ID: 19553660

Title: PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation.

PubMed ID: 19553660

DOI: 10.1074/jbc.m109.001990

PubMed ID: 19265708

Title: Human PinX1 mediates TRF1 accumulation in nucleolus and enhances TRF1 binding to telomeres.

PubMed ID: 19265708

DOI: 10.1016/j.jmb.2009.02.051

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27847364

Title: Enterovirus 71 3C Promotes Apoptosis through Cleavage of PinX1, a Telomere Binding Protein.

PubMed ID: 27847364

DOI: 10.1128/jvi.02016-16

Sequence Information:

  • Length: 328
  • Mass: 37035
  • Checksum: A298B31AEA6D18E1
  • Sequence:
  • MSMLAERRRK QKWAVDPQNT AWSNDDSKFG QRMLEKMGWS KGKGLGAQEQ GATDHIKVQV 
    KNNHLGLGAT INNEDNWIAH QDDFNQLLAE LNTCHGQETT DSSDKKEKKS FSLEEKSKIS 
    KNRVHYMKFT KGKDLSSRSK TDLDCIFGKR QSKKTPEGDA SPSTPEENET TTTSAFTIQE 
    YFAKRMAALK NKPQVPVPGS DISETQVERK RGKKRNKEAT GKDVESYLQP KAKRHTEGKP 
    ERAEAQERVA KKKSAPAEEQ LRGPCWDQSS KASAQDAGDH VQPPEGRDFT LKPKKRRGKK 
    KLQKPVEIAE DATLEETLVK KKKKKDSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.