Details for: ACP3

Gene ID: 55

Symbol: ACP3

Ensembl ID: ENSG00000014257

Description: acid phosphatase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 39.0883
    Cell Significance Index: -6.0800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 8.9113
    Cell Significance Index: 92.2200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.0121
    Cell Significance Index: -5.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.9150
    Cell Significance Index: -6.0600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 4.7115
    Cell Significance Index: 68.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6054
    Cell Significance Index: 158.8100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.4685
    Cell Significance Index: 9.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8812
    Cell Significance Index: 795.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8268
    Cell Significance Index: 11.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5590
    Cell Significance Index: 90.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5433
    Cell Significance Index: 59.1000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5279
    Cell Significance Index: 4.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5171
    Cell Significance Index: 14.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.4060
    Cell Significance Index: 59.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3533
    Cell Significance Index: 21.2100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3318
    Cell Significance Index: 5.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3155
    Cell Significance Index: 21.8200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.2602
    Cell Significance Index: 2.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2489
    Cell Significance Index: 47.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2436
    Cell Significance Index: 6.0900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.2045
    Cell Significance Index: 2.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1526
    Cell Significance Index: 111.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1366
    Cell Significance Index: 27.1100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1197
    Cell Significance Index: 1.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1169
    Cell Significance Index: 5.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0974
    Cell Significance Index: 2.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0837
    Cell Significance Index: 2.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0764
    Cell Significance Index: 33.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0650
    Cell Significance Index: 2.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0543
    Cell Significance Index: 6.6800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0507
    Cell Significance Index: 0.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0436
    Cell Significance Index: 7.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0406
    Cell Significance Index: 0.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0393
    Cell Significance Index: 1.3800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0336
    Cell Significance Index: 0.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0228
    Cell Significance Index: 12.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0134
    Cell Significance Index: 2.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0119
    Cell Significance Index: 0.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0066
    Cell Significance Index: 4.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0057
    Cell Significance Index: 3.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0043
    Cell Significance Index: 8.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0038
    Cell Significance Index: 0.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0018
    Cell Significance Index: -0.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0018
    Cell Significance Index: -1.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0030
    Cell Significance Index: -0.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0032
    Cell Significance Index: -1.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0036
    Cell Significance Index: -6.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0044
    Cell Significance Index: -6.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0048
    Cell Significance Index: -6.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0108
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0119
    Cell Significance Index: -8.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0120
    Cell Significance Index: -4.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0122
    Cell Significance Index: -5.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0128
    Cell Significance Index: -0.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0145
    Cell Significance Index: -1.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0155
    Cell Significance Index: -4.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0284
    Cell Significance Index: -3.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0301
    Cell Significance Index: -3.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0366
    Cell Significance Index: -2.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0391
    Cell Significance Index: -4.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0418
    Cell Significance Index: -8.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0429
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0451
    Cell Significance Index: -7.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0465
    Cell Significance Index: -5.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0510
    Cell Significance Index: -6.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0513
    Cell Significance Index: -1.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0550
    Cell Significance Index: -5.7300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0557
    Cell Significance Index: -0.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0562
    Cell Significance Index: -1.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0583
    Cell Significance Index: -0.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0588
    Cell Significance Index: -1.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0593
    Cell Significance Index: -1.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0594
    Cell Significance Index: -3.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0616
    Cell Significance Index: -4.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0691
    Cell Significance Index: -3.6000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0705
    Cell Significance Index: -0.6400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0794
    Cell Significance Index: -1.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0837
    Cell Significance Index: -6.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0995
    Cell Significance Index: -6.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1062
    Cell Significance Index: -2.8900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1067
    Cell Significance Index: -0.8700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1069
    Cell Significance Index: -2.6700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1116
    Cell Significance Index: -4.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1149
    Cell Significance Index: -6.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1185
    Cell Significance Index: -5.2400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1199
    Cell Significance Index: -4.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1230
    Cell Significance Index: -5.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1307
    Cell Significance Index: -4.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1360
    Cell Significance Index: -8.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1388
    Cell Significance Index: -4.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1399
    Cell Significance Index: -4.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1423
    Cell Significance Index: -5.3900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1563
    Cell Significance Index: -2.2300
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1663
    Cell Significance Index: -2.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1720
    Cell Significance Index: -4.4200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1747
    Cell Significance Index: -2.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1822
    Cell Significance Index: -6.3300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1843
    Cell Significance Index: -5.8300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1909
    Cell Significance Index: -8.3000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1941
    Cell Significance Index: -3.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** ACP3 exhibits a wide range of enzymatic activities, including 5'-nucleotidase, acid phosphatase, and lysophosphatidic acid phosphatase, which are essential for various cellular processes. 2. **Cellular Localization:** ACP3 is predominantly expressed in specific cell types, including luminal cells of the prostate epithelium, retina horizontal cells, and endocrine cells. 3. **Signaling Pathways:** ACP3 is involved in various signaling pathways, including the adenosine receptor signaling pathway, regulation of sensory perception of pain, and immune response. 4. **Metabolic Processes:** ACP3 participates in metabolic processes, such as adenosine metabolic process, choline binding, and thiamine metabolic process. **Pathways and Functions:** 1. **Immune System:** ACP3 plays a crucial role in the immune system, particularly in the regulation of neutrophil degranulation and innate immune response. 2. **Neurotransmission:** ACP3 is involved in the regulation of sensory perception of pain and neurotransmission in the brain, particularly in GABAergic interneurons. 3. **Metabolic Regulation:** ACP3 participates in metabolic processes, including adenosine metabolic process, choline binding, and thiamine metabolic process. 4. **Cell Signaling:** ACP3 is involved in various signaling pathways, including the adenosine receptor signaling pathway and regulation of sensory perception of pain. **Clinical Significance:** 1. **Prostate Cancer:** ACP3 has been identified as a biomarker for prostate cancer, with elevated expression levels associated with tumor progression. 2. **Neurological Disorders:** ACP3 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Immune System Disorders:** ACP3 plays a crucial role in immune system disorders, such as autoimmune diseases and immunodeficiency disorders. 4. **Cancer Metastasis:** ACP3 has been shown to facilitate cancer metastasis by regulating various signaling pathways and metabolic processes. In conclusion, ACP3 is a multifunctional enzyme that plays a crucial role in various cellular processes, including immune response, neurotransmission, and metabolic regulation. Its involvement in multiple signaling pathways and metabolic processes underscores its significance in maintaining cellular homeostasis. Further research is needed to fully elucidate the role of ACP3 in human health and disease, with potential implications for the development of novel therapeutic strategies.

Genular Protein ID: 3414278605

Symbol: PPAP_HUMAN

Name: 5'-nucleotidase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1375464

Title: Structure of human prostatic acid phosphatase gene.

PubMed ID: 1375464

DOI: 10.1016/s0006-291x(05)80048-8

PubMed ID: 1989985

Title: Covalent structure, disulfide bonding, and identification of reactive surface and active site residues of human prostatic acid phosphatase.

PubMed ID: 1989985

DOI: 10.1016/s0021-9258(18)52245-6

PubMed ID: 2712834

Title: Human prostatic acid phosphatase: cDNA cloning, gene mapping and protein sequence homology with lysosomal acid phosphatase.

PubMed ID: 2712834

DOI: 10.1016/0006-291x(89)91623-9

PubMed ID: 2842184

Title: Molecular cloning and sequence analysis of cDNA encoding human prostatic acid phosphatase.

PubMed ID: 2842184

DOI: 10.1016/0014-5793(88)80037-1

PubMed ID: 2395659

Title: Nucleotide sequence of human prostatic acid phosphatase determined from a full-length cDNA clone.

PubMed ID: 2395659

DOI: 10.1093/nar/18.16.4928

PubMed ID: 7951074

Title: Nucleotide sequence of human prostatic acid phosphatase ACPP gene, including seven Alu repeats.

PubMed ID: 7951074

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3674882

Title: Structures of the carbohydrate moieties of human prostatic acid phosphatase elucidated by H1 nuclear magnetic resonance spectroscopy.

PubMed ID: 3674882

DOI: 10.1016/0003-9861(87)90361-4

PubMed ID: 9584846

Title: Covalent modification and site-directed mutagenesis of an active site tryptophan of human prostatic acid phosphatase.

PubMed ID: 9584846

PubMed ID: 10506173

Title: Isolation of a cDNA encoding human lysophosphatidic acid phosphatase that is involved in the regulation of mitochondrial lipid biosynthesis.

PubMed ID: 10506173

DOI: 10.1074/jbc.274.41.29172

PubMed ID: 15280042

Title: Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma.

PubMed ID: 15280042

DOI: 10.1016/j.febslet.2004.06.083

PubMed ID: 17638863

Title: Prostatic acid phosphatase is not a prostate specific target.

PubMed ID: 17638863

DOI: 10.1158/0008-5472.can-07-1651

PubMed ID: 18083097

Title: Semen-derived amyloid fibrils drastically enhance HIV infection.

PubMed ID: 18083097

DOI: 10.1016/j.cell.2007.10.014

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 19403677

Title: Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer.

PubMed ID: 19403677

DOI: 10.1128/jvi.00268-09

PubMed ID: 19451623

Title: The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection.

PubMed ID: 19451623

DOI: 10.1073/pnas.0811827106

PubMed ID: 19897482

Title: Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection).

PubMed ID: 19897482

DOI: 10.1074/jbc.m109.066167

PubMed ID: 20498373

Title: Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth.

PubMed ID: 20498373

DOI: 10.1074/jbc.m109.098301

PubMed ID: 21487525

Title: Prostatic acid phosphatase expression in human tissues.

PubMed ID: 21487525

PubMed ID: 9804805

Title: Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase.

PubMed ID: 9804805

DOI: 10.1074/jbc.273.46.30406

PubMed ID: 10639192

Title: Crystal structure of human prostatic acid phosphatase.

PubMed ID: 10639192

DOI: 10.1002/(sici)1097-0045(20000215)42:3<211::aid-pros7>3.0.co;2-u

PubMed ID: 12525165

Title: Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design.

PubMed ID: 12525165

DOI: 10.1021/bi0265067

PubMed ID: 19995078

Title: NMR structure in a membrane environment reveals putative amyloidogenic regions of the SEVI precursor peptide PAP(248-286).

PubMed ID: 19995078

DOI: 10.1021/ja908170s

Sequence Information:

  • Length: 386
  • Mass: 44566
  • Checksum: EF81E11DFAECADEA
  • Sequence:
  • MRAAPLLLAR AASLSLGFLF LLFFWLDRSV LAKELKFVTL VFRHGDRSPI DTFPTDPIKE 
    SSWPQGFGQL TQLGMEQHYE LGEYIRKRYR KFLNESYKHE QVYIRSTDVD RTLMSAMTNL 
    AALFPPEGVS IWNPILLWQP IPVHTVPLSE DQLLYLPFRN CPRFQELESE TLKSEEFQKR 
    LHPYKDFIAT LGKLSGLHGQ DLFGIWSKVY DPLYCESVHN FTLPSWATED TMTKLRELSE 
    LSLLSLYGIH KQKEKSRLQG GVLVNEILNH MKRATQIPSY KKLIMYSAHD TTVSGLQMAL 
    DVYNGLLPPY ASCHLTELYF EKGEYFVEMY YRNETQHEPY PLMLPGCSPS CPLERFAELV 
    GPVIPQDWST ECMTTNSHQG TEDSTD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.