Details for: ACP3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 39.0883
Cell Significance Index: -6.0800 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 8.9113
Cell Significance Index: 92.2200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 6.0121
Cell Significance Index: -5.7400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 4.9150
Cell Significance Index: -6.0600 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 4.7115
Cell Significance Index: 68.4100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6054
Cell Significance Index: 158.8100 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.4685
Cell Significance Index: 9.0600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8812
Cell Significance Index: 795.6400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.8268
Cell Significance Index: 11.2800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5590
Cell Significance Index: 90.9200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5433
Cell Significance Index: 59.1000 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.5279
Cell Significance Index: 4.2200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5171
Cell Significance Index: 14.4500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.4060
Cell Significance Index: 59.0200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3533
Cell Significance Index: 21.2100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.3318
Cell Significance Index: 5.0000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3155
Cell Significance Index: 21.8200 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.2602
Cell Significance Index: 2.3100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2489
Cell Significance Index: 47.3700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2436
Cell Significance Index: 6.0900 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.2045
Cell Significance Index: 2.5300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1526
Cell Significance Index: 111.9200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1366
Cell Significance Index: 27.1100 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.1197
Cell Significance Index: 1.6800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1169
Cell Significance Index: 5.4500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0974
Cell Significance Index: 2.1100 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0837
Cell Significance Index: 2.2000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0764
Cell Significance Index: 33.7700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0650
Cell Significance Index: 2.9500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0543
Cell Significance Index: 6.6800 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.0507
Cell Significance Index: 0.7600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0436
Cell Significance Index: 7.8600 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.0406
Cell Significance Index: 0.7500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0393
Cell Significance Index: 1.3800 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0336
Cell Significance Index: 0.5200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0228
Cell Significance Index: 12.4500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0134
Cell Significance Index: 2.6800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0119
Cell Significance Index: 0.8400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0066
Cell Significance Index: 4.9700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0057
Cell Significance Index: 3.5900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0043
Cell Significance Index: 8.1900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0038
Cell Significance Index: 0.1100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0018
Cell Significance Index: -0.1100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0018
Cell Significance Index: -1.2500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0030
Cell Significance Index: -0.0800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0032
Cell Significance Index: -1.8300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0036
Cell Significance Index: -6.5500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0044
Cell Significance Index: -6.7600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0048
Cell Significance Index: -6.4700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0108
Cell Significance Index: -0.2300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0119
Cell Significance Index: -8.7800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0120
Cell Significance Index: -4.3200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0122
Cell Significance Index: -5.5300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0128
Cell Significance Index: -0.4100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0145
Cell Significance Index: -1.9900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0155
Cell Significance Index: -4.4500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0284
Cell Significance Index: -3.3500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0301
Cell Significance Index: -3.0800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0366
Cell Significance Index: -2.9000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0391
Cell Significance Index: -4.4800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0418
Cell Significance Index: -8.8000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0429
Cell Significance Index: -2.2300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0451
Cell Significance Index: -7.7000 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0465
Cell Significance Index: -5.9600 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0510
Cell Significance Index: -6.5900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0513
Cell Significance Index: -1.5100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0550
Cell Significance Index: -5.7300 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.0557
Cell Significance Index: -0.3700 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0562
Cell Significance Index: -1.2300 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0583
Cell Significance Index: -0.8400 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0588
Cell Significance Index: -1.2200 - Cell Name: peg cell (CL4033014)
Fold Change: -0.0593
Cell Significance Index: -1.3700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0594
Cell Significance Index: -3.0000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0616
Cell Significance Index: -4.5900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0691
Cell Significance Index: -3.6000 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.0705
Cell Significance Index: -0.6400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0794
Cell Significance Index: -1.3600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0837
Cell Significance Index: -6.4200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0995
Cell Significance Index: -6.4200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1062
Cell Significance Index: -2.8900 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1067
Cell Significance Index: -0.8700 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1069
Cell Significance Index: -2.6700 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1116
Cell Significance Index: -4.1000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1149
Cell Significance Index: -6.4500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1185
Cell Significance Index: -5.2400 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1199
Cell Significance Index: -4.9100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1230
Cell Significance Index: -5.7800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1307
Cell Significance Index: -4.5800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1360
Cell Significance Index: -8.5700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1388
Cell Significance Index: -4.4200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1399
Cell Significance Index: -4.5800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1423
Cell Significance Index: -5.3900 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.1563
Cell Significance Index: -2.2300 - Cell Name: endocrine cell (CL0000163)
Fold Change: -0.1663
Cell Significance Index: -2.0100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1720
Cell Significance Index: -4.4200 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.1747
Cell Significance Index: -2.0700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1822
Cell Significance Index: -6.3300 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.1843
Cell Significance Index: -5.8300 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1909
Cell Significance Index: -8.3000 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1941
Cell Significance Index: -3.8000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3414278605
Symbol: PPAP_HUMAN
Name: 5'-nucleotidase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1375464
Title: Structure of human prostatic acid phosphatase gene.
PubMed ID: 1375464
PubMed ID: 1989985
Title: Covalent structure, disulfide bonding, and identification of reactive surface and active site residues of human prostatic acid phosphatase.
PubMed ID: 1989985
PubMed ID: 2712834
Title: Human prostatic acid phosphatase: cDNA cloning, gene mapping and protein sequence homology with lysosomal acid phosphatase.
PubMed ID: 2712834
PubMed ID: 2842184
Title: Molecular cloning and sequence analysis of cDNA encoding human prostatic acid phosphatase.
PubMed ID: 2842184
PubMed ID: 2395659
Title: Nucleotide sequence of human prostatic acid phosphatase determined from a full-length cDNA clone.
PubMed ID: 2395659
PubMed ID: 7951074
Title: Nucleotide sequence of human prostatic acid phosphatase ACPP gene, including seven Alu repeats.
PubMed ID: 7951074
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3674882
Title: Structures of the carbohydrate moieties of human prostatic acid phosphatase elucidated by H1 nuclear magnetic resonance spectroscopy.
PubMed ID: 3674882
PubMed ID: 9584846
Title: Covalent modification and site-directed mutagenesis of an active site tryptophan of human prostatic acid phosphatase.
PubMed ID: 9584846
PubMed ID: 10506173
Title: Isolation of a cDNA encoding human lysophosphatidic acid phosphatase that is involved in the regulation of mitochondrial lipid biosynthesis.
PubMed ID: 10506173
PubMed ID: 15280042
Title: Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma.
PubMed ID: 15280042
PubMed ID: 17638863
Title: Prostatic acid phosphatase is not a prostate specific target.
PubMed ID: 17638863
PubMed ID: 18083097
Title: Semen-derived amyloid fibrils drastically enhance HIV infection.
PubMed ID: 18083097
PubMed ID: 17897319
Title: Integral and associated lysosomal membrane proteins.
PubMed ID: 17897319
PubMed ID: 19403677
Title: Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer.
PubMed ID: 19403677
DOI: 10.1128/jvi.00268-09
PubMed ID: 19451623
Title: The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection.
PubMed ID: 19451623
PubMed ID: 19897482
Title: Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection).
PubMed ID: 19897482
PubMed ID: 20498373
Title: Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth.
PubMed ID: 20498373
PubMed ID: 21487525
Title: Prostatic acid phosphatase expression in human tissues.
PubMed ID: 21487525
PubMed ID: 9804805
Title: Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase.
PubMed ID: 9804805
PubMed ID: 10639192
Title: Crystal structure of human prostatic acid phosphatase.
PubMed ID: 10639192
DOI: 10.1002/(sici)1097-0045(20000215)42:3<211::aid-pros7>3.0.co;2-u
PubMed ID: 12525165
Title: Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design.
PubMed ID: 12525165
DOI: 10.1021/bi0265067
PubMed ID: 19995078
Title: NMR structure in a membrane environment reveals putative amyloidogenic regions of the SEVI precursor peptide PAP(248-286).
PubMed ID: 19995078
DOI: 10.1021/ja908170s
Sequence Information:
- Length: 386
- Mass: 44566
- Checksum: EF81E11DFAECADEA
- Sequence:
MRAAPLLLAR AASLSLGFLF LLFFWLDRSV LAKELKFVTL VFRHGDRSPI DTFPTDPIKE SSWPQGFGQL TQLGMEQHYE LGEYIRKRYR KFLNESYKHE QVYIRSTDVD RTLMSAMTNL AALFPPEGVS IWNPILLWQP IPVHTVPLSE DQLLYLPFRN CPRFQELESE TLKSEEFQKR LHPYKDFIAT LGKLSGLHGQ DLFGIWSKVY DPLYCESVHN FTLPSWATED TMTKLRELSE LSLLSLYGIH KQKEKSRLQG GVLVNEILNH MKRATQIPSY KKLIMYSAHD TTVSGLQMAL DVYNGLLPPY ASCHLTELYF EKGEYFVEMY YRNETQHEPY PLMLPGCSPS CPLERFAELV GPVIPQDWST ECMTTNSHQG TEDSTD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.