Details for: ACP3

Gene ID: 55

Symbol: ACP3

Ensembl ID: ENSG00000014257

Description: acid phosphatase 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.06
    Marker Score: 1,782
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 2.03
    Marker Score: 1,950
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.68
    Marker Score: 871
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.33
    Marker Score: 3,575
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 848
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 790
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.03
    Marker Score: 2,532
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,809
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,034
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.93
    Marker Score: 219
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,238
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.87
    Marker Score: 7,511
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,282
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 677
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 293
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 359
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.55
    Marker Score: 561
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.52
    Marker Score: 1,190
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.51
    Marker Score: 3,978
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.51
    Marker Score: 422
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.49
    Marker Score: 484
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.49
    Marker Score: 342
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.46
    Marker Score: 482
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.45
    Marker Score: 185
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.43
    Marker Score: 215
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.42
    Marker Score: 421
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.42
    Marker Score: 478
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.41
    Marker Score: 131
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.38
    Marker Score: 1,510
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.38
    Marker Score: 194
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.37
    Marker Score: 6,016
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.37
    Marker Score: 914
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.37
    Marker Score: 248
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.37
    Marker Score: 356
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.36
    Marker Score: 96
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.36
    Marker Score: 20,340
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 92
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.35
    Marker Score: 179
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.35
    Marker Score: 557
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.35
    Marker Score: 2,259
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.33
    Marker Score: 352
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.33
    Marker Score: 210
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.32
    Marker Score: 589
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.32
    Marker Score: 337
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.31
    Marker Score: 111
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3
    Marker Score: 192
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.29
    Marker Score: 294
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.29
    Marker Score: 97
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.28
    Marker Score: 722
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.28
    Marker Score: 107
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.27
    Marker Score: 69
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.27
    Marker Score: 240
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.27
    Marker Score: 69
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.26
    Marker Score: 118
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.26
    Marker Score: 2,629
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.26
    Marker Score: 160
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 152
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.25
    Marker Score: 227
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.25
    Marker Score: 63
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.25
    Marker Score: 63
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.25
    Marker Score: 65
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.25
    Marker Score: 78
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.24
    Marker Score: 658
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 71
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.23
    Marker Score: 95
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.23
    Marker Score: 2,646
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.23
    Marker Score: 103
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.23
    Marker Score: 439
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.22
    Marker Score: 704
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.22
    Marker Score: 190
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.22
    Marker Score: 349
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.22
    Marker Score: 90
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.21
    Marker Score: 100
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.21
    Marker Score: 209
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.21
    Marker Score: 145
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.21
    Marker Score: 145
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.21
    Marker Score: 128
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.21
    Marker Score: 519
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.21
    Marker Score: 206
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.2
    Marker Score: 88
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.2
    Marker Score: 262
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.2
    Marker Score: 239
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.19
    Marker Score: 61
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.19
    Marker Score: 210
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.19
    Marker Score: 210

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** ACP3 exhibits a wide range of enzymatic activities, including 5'-nucleotidase, acid phosphatase, and lysophosphatidic acid phosphatase, which are essential for various cellular processes. 2. **Cellular Localization:** ACP3 is predominantly expressed in specific cell types, including luminal cells of the prostate epithelium, retina horizontal cells, and endocrine cells. 3. **Signaling Pathways:** ACP3 is involved in various signaling pathways, including the adenosine receptor signaling pathway, regulation of sensory perception of pain, and immune response. 4. **Metabolic Processes:** ACP3 participates in metabolic processes, such as adenosine metabolic process, choline binding, and thiamine metabolic process. **Pathways and Functions:** 1. **Immune System:** ACP3 plays a crucial role in the immune system, particularly in the regulation of neutrophil degranulation and innate immune response. 2. **Neurotransmission:** ACP3 is involved in the regulation of sensory perception of pain and neurotransmission in the brain, particularly in GABAergic interneurons. 3. **Metabolic Regulation:** ACP3 participates in metabolic processes, including adenosine metabolic process, choline binding, and thiamine metabolic process. 4. **Cell Signaling:** ACP3 is involved in various signaling pathways, including the adenosine receptor signaling pathway and regulation of sensory perception of pain. **Clinical Significance:** 1. **Prostate Cancer:** ACP3 has been identified as a biomarker for prostate cancer, with elevated expression levels associated with tumor progression. 2. **Neurological Disorders:** ACP3 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Immune System Disorders:** ACP3 plays a crucial role in immune system disorders, such as autoimmune diseases and immunodeficiency disorders. 4. **Cancer Metastasis:** ACP3 has been shown to facilitate cancer metastasis by regulating various signaling pathways and metabolic processes. In conclusion, ACP3 is a multifunctional enzyme that plays a crucial role in various cellular processes, including immune response, neurotransmission, and metabolic regulation. Its involvement in multiple signaling pathways and metabolic processes underscores its significance in maintaining cellular homeostasis. Further research is needed to fully elucidate the role of ACP3 in human health and disease, with potential implications for the development of novel therapeutic strategies.

Genular Protein ID: 3414278605

Symbol: PPAP_HUMAN

Name: 5'-nucleotidase

UniProtKB Accession Codes:

P15309 D3DNC6 Q5FBY0 Q96KY0 Q96QK9 Q96QM0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 3 DrugCentral 1 EC 3 EMBL 31 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 10 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 7 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1375464

Title: Structure of human prostatic acid phosphatase gene.

PubMed ID: 1375464

DOI: 10.1016/s0006-291x(05)80048-8

PubMed ID: 1989985

Title: Covalent structure, disulfide bonding, and identification of reactive surface and active site residues of human prostatic acid phosphatase.

PubMed ID: 1989985

DOI: 10.1016/s0021-9258(18)52245-6

PubMed ID: 2712834

Title: Human prostatic acid phosphatase: cDNA cloning, gene mapping and protein sequence homology with lysosomal acid phosphatase.

PubMed ID: 2712834

DOI: 10.1016/0006-291x(89)91623-9

PubMed ID: 2842184

Title: Molecular cloning and sequence analysis of cDNA encoding human prostatic acid phosphatase.

PubMed ID: 2842184

DOI: 10.1016/0014-5793(88)80037-1

PubMed ID: 2395659

Title: Nucleotide sequence of human prostatic acid phosphatase determined from a full-length cDNA clone.

PubMed ID: 2395659

DOI: 10.1093/nar/18.16.4928

PubMed ID: 7951074

Title: Nucleotide sequence of human prostatic acid phosphatase ACPP gene, including seven Alu repeats.

PubMed ID: 7951074

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3674882

Title: Structures of the carbohydrate moieties of human prostatic acid phosphatase elucidated by H1 nuclear magnetic resonance spectroscopy.

PubMed ID: 3674882

DOI: 10.1016/0003-9861(87)90361-4

PubMed ID: 9584846

Title: Covalent modification and site-directed mutagenesis of an active site tryptophan of human prostatic acid phosphatase.

PubMed ID: 9584846

PubMed ID: 10506173

Title: Isolation of a cDNA encoding human lysophosphatidic acid phosphatase that is involved in the regulation of mitochondrial lipid biosynthesis.

PubMed ID: 10506173

DOI: 10.1074/jbc.274.41.29172

PubMed ID: 15280042

Title: Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma.

PubMed ID: 15280042

DOI: 10.1016/j.febslet.2004.06.083

PubMed ID: 17638863

Title: Prostatic acid phosphatase is not a prostate specific target.

PubMed ID: 17638863

DOI: 10.1158/0008-5472.can-07-1651

PubMed ID: 18083097

Title: Semen-derived amyloid fibrils drastically enhance HIV infection.

PubMed ID: 18083097

DOI: 10.1016/j.cell.2007.10.014

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 19403677

Title: Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer.

PubMed ID: 19403677

DOI: 10.1128/jvi.00268-09

PubMed ID: 19451623

Title: The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection.

PubMed ID: 19451623

DOI: 10.1073/pnas.0811827106

PubMed ID: 19897482

Title: Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection).

PubMed ID: 19897482

DOI: 10.1074/jbc.m109.066167

PubMed ID: 20498373

Title: Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth.

PubMed ID: 20498373

DOI: 10.1074/jbc.m109.098301

PubMed ID: 21487525

Title: Prostatic acid phosphatase expression in human tissues.

PubMed ID: 21487525

PubMed ID: 9804805

Title: Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase.

PubMed ID: 9804805

DOI: 10.1074/jbc.273.46.30406

PubMed ID: 10639192

Title: Crystal structure of human prostatic acid phosphatase.

PubMed ID: 10639192

DOI: 10.1002/(sici)1097-0045(20000215)42:3<211::aid-pros7>3.0.co;2-u

PubMed ID: 12525165

Title: Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design.

PubMed ID: 12525165

DOI: 10.1021/bi0265067

PubMed ID: 19995078

Title: NMR structure in a membrane environment reveals putative amyloidogenic regions of the SEVI precursor peptide PAP(248-286).

PubMed ID: 19995078

DOI: 10.1021/ja908170s

Sequence Information:

  • Length: 386
  • Mass: 44566
  • Checksum: EF81E11DFAECADEA
  • Sequence:
    • MRAAPLLLAR AASLSLGFLF LLFFWLDRSV LAKELKFVTL VFRHGDRSPI DTFPTDPIKE 
SSWPQGFGQL TQLGMEQHYE LGEYIRKRYR KFLNESYKHE QVYIRSTDVD RTLMSAMTNL 
AALFPPEGVS IWNPILLWQP IPVHTVPLSE DQLLYLPFRN CPRFQELESE TLKSEEFQKR 
LHPYKDFIAT LGKLSGLHGQ DLFGIWSKVY DPLYCESVHN FTLPSWATED TMTKLRELSE 
LSLLSLYGIH KQKEKSRLQG GVLVNEILNH MKRATQIPSY KKLIMYSAHD TTVSGLQMAL 
DVYNGLLPPY ASCHLTELYF EKGEYFVEMY YRNETQHEPY PLMLPGCSPS CPLERFAELV 
GPVIPQDWST ECMTTNSHQG TEDSTD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.