Details for: AUP1

Gene ID: 550

Symbol: AUP1

Ensembl ID: ENSG00000115307

Description: AUP1 lipid droplet regulating VLDL assembly factor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.34
    Marker Score: 2439
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2
    Marker Score: 5018
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.12
    Marker Score: 24588
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2
    Marker Score: 26897
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.96
    Marker Score: 3828
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.92
    Marker Score: 1636
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.89
    Marker Score: 5929
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.89
    Marker Score: 2778
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.85
    Marker Score: 1736
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.83
    Marker Score: 7206
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.83
    Marker Score: 2434
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.83
    Marker Score: 1155
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.82
    Marker Score: 8733.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.81
    Marker Score: 7797
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.79
    Marker Score: 1408
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.78
    Marker Score: 3106
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.77
    Marker Score: 98917
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.76
    Marker Score: 15141
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.74
    Marker Score: 5170
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.74
    Marker Score: 4240
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.7
    Marker Score: 4032.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.69
    Marker Score: 1820
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.69
    Marker Score: 43175
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.68
    Marker Score: 10752
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.67
    Marker Score: 1772
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.66
    Marker Score: 1211
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.66
    Marker Score: 12360
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.66
    Marker Score: 775
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.65
    Marker Score: 5220.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.65
    Marker Score: 12848
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.64
    Marker Score: 1025
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.64
    Marker Score: 903
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.64
    Marker Score: 959
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.63
    Marker Score: 1870.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.63
    Marker Score: 4448
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.63
    Marker Score: 6971
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.62
    Marker Score: 4029
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.62
    Marker Score: 1171
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.61
    Marker Score: 1625
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.61
    Marker Score: 385
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.61
    Marker Score: 2553
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.6
    Marker Score: 6188
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.6
    Marker Score: 557
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.6
    Marker Score: 1060.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.59
    Marker Score: 84007.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.59
    Marker Score: 6496
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.59
    Marker Score: 2335
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.58
    Marker Score: 662
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.58
    Marker Score: 645
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.58
    Marker Score: 1387
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.58
    Marker Score: 2286
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.58
    Marker Score: 1980
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.58
    Marker Score: 2230
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.57
    Marker Score: 1901
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.57
    Marker Score: 3835
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.57
    Marker Score: 2255
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.57
    Marker Score: 1475
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.56
    Marker Score: 1183
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.56
    Marker Score: 4313
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.55
    Marker Score: 544
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.55
    Marker Score: 3523
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.55
    Marker Score: 9903
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.55
    Marker Score: 632
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.55
    Marker Score: 497
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.55
    Marker Score: 10070
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.54
    Marker Score: 1030
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.53
    Marker Score: 3235
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.53
    Marker Score: 1255
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.53
    Marker Score: 1834
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.52
    Marker Score: 1268
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.52
    Marker Score: 2974
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.52
    Marker Score: 2488
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.52
    Marker Score: 1353
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.52
    Marker Score: 913
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.51
    Marker Score: 15218.5
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.51
    Marker Score: 305
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.51
    Marker Score: 3154
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.51
    Marker Score: 427
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.51
    Marker Score: 1506.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.51
    Marker Score: 829
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.51
    Marker Score: 1455
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.5
    Marker Score: 1525
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.49
    Marker Score: 362
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.49
    Marker Score: 1740
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.49
    Marker Score: 368
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.48
    Marker Score: 739
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.48
    Marker Score: 1535
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.48
    Marker Score: 2616
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.47
    Marker Score: 2625
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.47
    Marker Score: 1597
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.47
    Marker Score: 1406
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.46
    Marker Score: 550
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.46
    Marker Score: 916
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.46
    Marker Score: 50458
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.45
    Marker Score: 441
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.45
    Marker Score: 709
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.45
    Marker Score: 381
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.44
    Marker Score: 316
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.44
    Marker Score: 1198
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.44
    Marker Score: 758

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - AUP1 is a protein of the immunoglobulin superfamily. - It is expressed in a variety of cell types, including erythroid progenitor cells, acinar cells of the salivary gland, blood cells, malignant cells, CD14-positive and CD16-positive monocytes, IgA plasma cells, colon epithelial cells, bladder urothelial cells, class switched memory B cells, and placental villous trophoblast cells. - AUP1 is a secreted protein that is thought to be a lipid droplet-regulating factor. **Pathways and functions:** - AUP1 is involved in the assembly of VLDL particles by binding to apolipoprotein B and facilitating its interaction with the low-density lipoprotein receptor. - AUP1 also binds to the Erap1 protein, which is a key regulator of the Erad pathway. - AUP1 is involved in the regulation of other lipid droplet-related pathways, including the retrograde protein transport pathway. - AUP1 is also involved in the regulation of inflammation and immune responses. **Clinical significance:** - Mutations in AUP1 have been linked to the pathogenesis of several diseases, including atherosclerosis, diabetes, and cancer. - AUP1 is a potential therapeutic target for these diseases.

Genular Protein ID: 4288265857

Symbol: AUP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y679 C0H5W8 Q9H866 Q9UNQ6 Q9Y685

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12042322

Title: Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3.

PubMed ID: 12042322

DOI: 10.1074/jbc.m204340200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18711132

Title: SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins.

PubMed ID: 18711132

DOI: 10.1073/pnas.0805371105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21127063

Title: Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (Ube2g2) via its G2 binding region.

PubMed ID: 21127063

DOI: 10.1074/jbc.m110.190785

PubMed ID: 21857022

Title: Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control.

PubMed ID: 21857022

DOI: 10.1074/jbc.m111.284794

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23197321

Title: Monotopic topology is required for lipid droplet targeting of ancient ubiquitous protein 1.

PubMed ID: 23197321

DOI: 10.1194/jlr.m033852

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23223569

Title: Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes.

PubMed ID: 23223569

DOI: 10.1091/mbc.e12-07-0564

PubMed ID: 24039768

Title: Monoubiquitination of ancient ubiquitous protein 1 promotes lipid droplet clustering.

PubMed ID: 24039768

DOI: 10.1371/journal.pone.0072453

PubMed ID: 28183703

Title: AUP1 (Ancient Ubiquitous Protein 1) Is a Key Determinant of Hepatic Very-Low-Density Lipoprotein Assembly and Secretion.

PubMed ID: 28183703

DOI: 10.1161/atvbaha.117.309000

PubMed ID: 29902443

Title: Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production.

PubMed ID: 29902443

DOI: 10.1016/j.chom.2018.05.005

Sequence Information:

  • Length: 410
  • Mass: 45787
  • Checksum: 1A06476225C5DFDC
  • Sequence:
    • MELPSGPGPE RLFDSHRLPG DCFLLLVLLL YAPVGFCLLV LRLFLGIHVF LVSCALPDSV 
LRRFVVRTMC AVLGLVARQE DSGLRDHSVR VLISNHVTPF DHNIVNLLTT CSTPLLNSPP 
SFVCWSRGFM EMNGRGELVE SLKRFCASTR LPPTPLLLFP EEEATNGREG LLRFSSWPFS 
IQDVVQPLTL QVQRPLVSVT VSDASWVSEL LWSLFVPFTV YQVRWLRPVH RQLGEANEEF 
ALRVQQLVAK ELGQTGTRLT PADKAEHMKR QRHPRLRPQS AQSSFPPSPG PSPDVQLATL 
AQRVKEVLPH VPLGVIQRDL AKTGCVDLTI TNLLEGAVAF MPEDITKGTQ SLPTASASKF 
PSSGPVTPQP TALTFAKSSW ARQESLQERK QALYEYARRR FTERRAQEAD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.