Details for: LAMTOR1

Gene ID: 55004

Symbol: LAMTOR1

Ensembl ID: ENSG00000149357

Description: late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

Associated with

Other Information

Genular Protein ID: 3069597648

Symbol: LTOR1_HUMAN

Name: Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1

UniProtKB Accession Codes:

Q6IAA8 Q8WZ09 Q9NWT0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 12 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 31 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 44 PDBsum 20 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 16 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19654316

Title: A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion.

PubMed ID: 19654316

DOI: 10.1074/jbc.m109.041400

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20381137

Title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

PubMed ID: 20381137

DOI: 10.1016/j.cell.2010.02.024

PubMed ID: 20544018

Title: Pdro, a protein associated with late endosomes and lysosomes and implicated in cellular cholesterol homeostasis.

PubMed ID: 20544018

DOI: 10.1371/journal.pone.0010977

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22980980

Title: Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1.

PubMed ID: 22980980

DOI: 10.1016/j.cell.2012.07.032

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25807930

Title: Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

PubMed ID: 25807930

DOI: 10.1002/anie.201500342

PubMed ID: 25561175

Title: SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.

PubMed ID: 25561175

DOI: 10.1038/nature14107

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25567906

Title: Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

PubMed ID: 25567906

DOI: 10.1126/science.1257132

PubMed ID: 29644770

Title: TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation.

PubMed ID: 29644770

DOI: 10.1111/gtc.12583

PubMed ID: 30020076

Title: UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity.

PubMed ID: 30020076

DOI: 10.7554/elife.37993

PubMed ID: 30181260

Title: Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.

PubMed ID: 30181260

DOI: 10.1073/pnas.1811727115

PubMed ID: 31001086

Title: mTORC1 signaling is palmitoylation-dependent in hippocampal neurons and non-neuronal cells and involves dynamic palmitoylation of LAMTOR1 and mTOR.

PubMed ID: 31001086

DOI: 10.3389/fncel.2019.00115

PubMed ID: 32686708

Title: N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells.

PubMed ID: 32686708

DOI: 10.1038/s41598-020-68615-w

PubMed ID: 34999170

Title: N-myristoyltransferase-1 deficiency blocks myristoylation of LAMTOR1 and inhibits bladder cancer progression.

PubMed ID: 34999170

DOI: 10.1016/j.canlet.2022.01.001

PubMed ID: 36476874

Title: USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction.

PubMed ID: 36476874

DOI: 10.1016/j.celrep.2022.111653

PubMed ID: 35893977

Title: Structural exploration on palmitoyltransferase DHHC3 from Homo sapiens.

PubMed ID: 35893977

DOI: 10.3390/polym14153013

PubMed ID: 29285400

Title: Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane.

PubMed ID: 29285400

DOI: 10.1038/celldisc.2017.49

PubMed ID: 29107538

Title: Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.

PubMed ID: 29107538

DOI: 10.1016/j.molcel.2017.10.016

PubMed ID: 29123114

Title: Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.

PubMed ID: 29123114

DOI: 10.1038/s41467-017-01567-4

PubMed ID: 29158492

Title: Structural basis for the assembly of the Ragulator-Rag GTPase complex.

PubMed ID: 29158492

DOI: 10.1038/s41467-017-01762-3

PubMed ID: 28935770

Title: Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.

PubMed ID: 28935770

DOI: 10.1126/science.aao1583

PubMed ID: 31704029

Title: Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex.

PubMed ID: 31704029

DOI: 10.1016/j.cell.2019.10.036

PubMed ID: 31601708

Title: Structural basis for the docking of mTORC1 on the lysosomal surface.

PubMed ID: 31601708

DOI: 10.1126/science.aay0166

PubMed ID: 31672913

Title: Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.

PubMed ID: 31672913

DOI: 10.1126/science.aax0364

PubMed ID: 32868926

Title: Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.

PubMed ID: 32868926

DOI: 10.1038/s41594-020-0490-9

PubMed ID: 35338845

Title: Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.

PubMed ID: 35338845

DOI: 10.1016/j.molcel.2022.03.002

PubMed ID: 36103527

Title: Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.

PubMed ID: 36103527

DOI: 10.1126/sciadv.add2926

PubMed ID: 36697823

Title: Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.

PubMed ID: 36697823

DOI: 10.1038/s41586-022-05652-7

Sequence Information:

  • Length: 161
  • Mass: 17745
  • Checksum: 610CC6C548356051
  • Sequence:
    • MGCCYSSENE DSDQDREERK LLLDPSSPPT KALNGAEPNY HSLPSARTDE QALLSSILAK 
TASNIIDVSA ADSQGMEQHE YMDRARQYST RLAVLSSSLT HWKKLPPLPS LTSQPHQVLA 
SEPIPFSDLQ QVSRIAAYAY SALSQIRVDA KEELVVQFGI P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.