STX17 | ENSG00000136874 | NCBI 55014

Details for: STX17

Gene ID: 55014

Symbol: STX17

Ensembl ID: ENSG00000136874

Description: syntaxin 17

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Copii-mediated vesicle transport
(R-HSA-204005)
Er to golgi anterograde transport
(R-HSA-199977)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Autophagosome
(GO:0005776)
Autophagosome maturation
(GO:0097352)
Autophagosome membrane
(GO:0000421)
Autophagosome membrane docking
(GO:0016240)
Copii-coated er to golgi transport vesicle
(GO:0030134)
Cytosol
(GO:0005829)
Endomembrane system
(GO:0012505)
Endoplasmic reticulum-golgi intermediate compartment
(GO:0005793)
Endoplasmic reticulum-golgi intermediate compartment membrane
(GO:0033116)
Endoplasmic reticulum-golgi intermediate compartment organization
(GO:0097111)
Endoplasmic reticulum membrane
(GO:0005789)
Endoplasmic reticulum to golgi vesicle-mediated transport
(GO:0006888)
Er to golgi transport vesicle membrane
(GO:0012507)
Exocytosis
(GO:0006887)
Golgi organization
(GO:0007030)
Hops complex
(GO:0030897)
Intracellular protein transport
(GO:0006886)
Lysosomal membrane
(GO:0005765)
Mitochondria-associated endoplasmic reticulum membrane
(GO:0044233)
Mitochondrion
(GO:0005739)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein localization to phagophore assembly site
(GO:0034497)
Protein phosphatase binding
(GO:0019903)
Rough endoplasmic reticulum
(GO:0005791)
Smooth endoplasmic reticulum membrane
(GO:0030868)
Snap receptor activity
(GO:0005484)
Snare binding
(GO:0000149)
Snare complex
(GO:0031201)
Vesicle docking
(GO:0048278)
Vesicle fusion
(GO:0006906)

Other Information

Proteins

STX17_HUMAN

Genular Protein ID: 3833738669

Symbol: STX17_HUMAN

Name: N/A

UniProtKB Accession Codes:

P56962 Q4VXC2

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21545355

Title: Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi.

PubMed ID: 21545355

DOI: 10.1042/bc20110006

PubMed ID: 23006999

Title: Tyrosine phosphorylation of a SNARE protein, Syntaxin 17: Implications for membrane trafficking in the early secretory pathway.

PubMed ID: 23006999

DOI: 10.1016/j.bbamcr.2012.09.003

PubMed ID: 23217709

Title: The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes.

PubMed ID: 23217709

DOI: 10.1016/j.cell.2012.11.001

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26416964

Title: RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.

PubMed ID: 26416964

DOI: 10.1083/jcb.201501059

PubMed ID: 28306502

Title: Pacer mediates the function of class III PI3K and HOPS complexes in autophagosome maturation by engaging Stx17.

PubMed ID: 28306502

DOI: 10.1016/j.molcel.2017.02.010

PubMed ID: 28504273

Title: Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17.

PubMed ID: 28504273

DOI: 10.1038/ncomms15406

PubMed ID: 29420192

Title: Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins.

PubMed ID: 29420192

DOI: 10.1083/jcb.201708039

PubMed ID: 31806350

Title: The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.

PubMed ID: 31806350

DOI: 10.1016/j.molcel.2019.10.035

PubMed ID: 30704899

Title: Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.

PubMed ID: 30704899

DOI: 10.1016/j.molcel.2018.12.017

PubMed ID: 33422265

Title: ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.

PubMed ID: 33422265

DOI: 10.1016/j.devcel.2020.12.010

PubMed ID: 37632749

Title: MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy.

PubMed ID: 37632749

DOI: 10.1016/j.celrep.2023.113045

PubMed ID: 25686604

Title: ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.

PubMed ID: 25686604

DOI: 10.1038/nature14147

Sequence Information:

Length: 302
Mass: 33403
Checksum: 51AD5427EFBAC541
Sequence:

MSEDEEKVKL RRLEPAIQKF IKIVIPTDLE RLRKHQINIE KYQRCRIWDK LHEEHINAGR 
TVQQLRSNIR EIEKLCLKVR KDDLVLLKRM IDPVKEEASA ATAEFLQLHL ESVEELKKQF 
NDEETLLQPP LTRSMTVGGA FHTTEAEASS QSLTQIYALP EIPQDQNAAE SWETLEADLI 
ELSQLVTDFS LLVNSQQEKI DSIADHVNSA AVNVEEGTKN LGKAAKYKLA ALPVAGALIG 
GMVGGPIGLL AGFKVAGIAA ALGGGVLGFT GGKLIQRKKQ KMMEKLTSSC PDLPSQTDKK 
CS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: STX17

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi. PubMed ID: 21545355

Tyrosine phosphorylation of a SNARE protein, Syntaxin 17: Implications for membrane trafficking in the early secretory pathway. PubMed ID: 23006999

The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. PubMed ID: 23217709

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4. PubMed ID: 26416964

Pacer mediates the function of class III PI3K and HOPS complexes in autophagosome maturation by engaging Stx17. PubMed ID: 28306502

Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17. PubMed ID: 28504273

Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins. PubMed ID: 29420192

The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1. PubMed ID: 31806350

Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism. PubMed ID: 30704899

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation. PubMed ID: 33422265

MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy. PubMed ID: 37632749

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes. PubMed ID: 25686604