Details for: ATG16L1
Associated with
Other Information
Genular Protein ID: 2542188688
Symbol: A16L1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15620219
PubMed ID: 17200669
Title: A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.
PubMed ID: 17200669
DOI: 10.1038/ng1954
PubMed ID: 12975309
Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
PubMed ID: 12975309
DOI: 10.1101/gr.1293003
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 18849966
Title: A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.
PubMed ID: 18849966
DOI: 10.1038/nature07416
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20637199
Title: ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis.
PubMed ID: 20637199
PubMed ID: 20639872
Title: Plasma membrane contributes to the formation of pre-autophagosomal structures.
PubMed ID: 20639872
DOI: 10.1038/ncb2078
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21808068
Title: RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.
PubMed ID: 21808068
PubMed ID: 22749352
Title: The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.
PubMed ID: 22749352
PubMed ID: 23376921
Title: TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3.
PubMed ID: 23376921
DOI: 10.1038/emboj.2013.8
PubMed ID: 23392225
Title: FIP200 regulates targeting of Atg16L1 to the isolation membrane.
PubMed ID: 23392225
DOI: 10.1038/embor.2013.6
PubMed ID: 24238340
Title: The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner.
PubMed ID: 24238340
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23262492
Title: Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy.
PubMed ID: 23262492
DOI: 10.1038/nsmb.2475
PubMed ID: 26083323
Title: ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation.
PubMed ID: 26083323
PubMed ID: 26347139
Title: TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.
PubMed ID: 26347139
PubMed ID: 25891078
Title: IRGM governs the core autophagy machinery to conduct antimicrobial defense.
PubMed ID: 25891078
PubMed ID: 28561066
Title: WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.
PubMed ID: 28561066
DOI: 10.1038/ncomms15637
PubMed ID: 29317426
Title: The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes.
PubMed ID: 29317426
PubMed ID: 30143514
Title: TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy.
PubMed ID: 30143514
PubMed ID: 30778222
Title: Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes.
PubMed ID: 30778222
PubMed ID: 33087875
Title: SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy.
PubMed ID: 33087875
PubMed ID: 33909989
Title: Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.
PubMed ID: 33909989
PubMed ID: 23202584
Title: Structure of the human ATG12-ATG5 conjugate required for LC3 lipidation in autophagy.
PubMed ID: 23202584
DOI: 10.1038/nsmb.2431
PubMed ID: 24191030
Title: Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12.
PubMed ID: 24191030
PubMed ID: 25484072
Title: Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners.
PubMed ID: 25484072
PubMed ID: 26812546
Title: Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay.
PubMed ID: 26812546
DOI: 10.7554/elife.12245
PubMed ID: 17484864
Title: A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5.
PubMed ID: 17484864
PubMed ID: 17435756
Title: Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
PubMed ID: 17435756
DOI: 10.1038/ng2032
PubMed ID: 18047540
Title: ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands.
PubMed ID: 18047540
PubMed ID: 18499543
Title: ATG16L1 and IL23 receptor (IL23R) genes are associated with disease susceptibility in Hungarian CD patients.
PubMed ID: 18499543
PubMed ID: 19659808
Title: Autophagy 16-like 1 rs2241880 G allele is associated with Crohn's disease in German children.
PubMed ID: 19659808
PubMed ID: 18985712
Title: Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children.
PubMed ID: 18985712
DOI: 10.1002/ibd.20785
PubMed ID: 24656308
Title: Autophagy genes variants and paediatric Crohn's disease phenotype: a single-centre experience.
PubMed ID: 24656308
PubMed ID: 24553140
Title: A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.
PubMed ID: 24553140
DOI: 10.1038/nature13044
PubMed ID: 24954904
Title: WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.
PubMed ID: 24954904
PubMed ID: 25645662
Title: The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon.
PubMed ID: 25645662
PubMed ID: 27273576
Title: The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1.
PubMed ID: 27273576
DOI: 10.1038/ncomms11821
Sequence Information:
- Length: 607
- Mass: 68265
- Checksum: 5A5816AE2CF03CA0
- Sequence:
MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLAQKLQAEK HDVPNRHEIS PGHDGTWNDN QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQRK DREMQMNEAK IAECLQTISD LETECLDLRT KLCDLERANQ TLKDEYDALQ ITFTALEGKL RKTTEENQEL VTRWMAEKAQ EANRLNAENE KDSRRRQARL QKELAEAAKE PLPVEQDDDI EVIVDETSDH TEETSPVRAI SRAATKRLSQ PAGGLLDSIT NIFGRRSVSS FPVPQDNVDT HPGSGKEVRV PATALCVFDA HDGEVNAVQF SPGSRLLATG GMDRRVKLWE VFGEKCEFKG SLSGSNAGIT SIEFDSAGSY LLAASNDFAS RIWTVDDYRL RHTLTGHSGK VLSAKFLLDN ARIVSGSHDR TLKLWDLRSK VCIKTVFAGS SCNDIVCTEQ CVMSGHFDKK IRFWDIRSES IVREMELLGK ITALDLNPER TELLSCSRDD LLKVIDLRTN AIKQTFSAPG FKCGSDWTRV VFSPDGSYVA AGSAEGSLYI WSVLTGKVEK VLSKQHSSSI NAVAWSPSGS HVVSVDKGCK AVLWAQY
Genular Protein ID: 1058176731
Symbol: Q17RG0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 580
- Mass: 64944
- Checksum: 040D0A9ED95C86B0
- Sequence:
QRQAFEEIIL QYNKLLEKSD LHSVLAQKLQ AEKHDVPNRH EISPGHDGTW NDNQLQEMAQ LRIKHQEELT ELHKKRGELA QLVIDLNNQM QRKDREMQMN EAKIAECLQT ISDLETECLD LRTKLCDLER ANQTLKDEYD ALQITFTALE GKLRKTTEEN QELVTRWMAE KAQEANRLNA ENEKDSRRRQ ARLQKELAEA AKEPLPVEQD DDIEVIVDET SDHTEETSPV RAISRAATKR LSQPAGGLLD SITNIFGRRS VSSFPVPQDN VDTHPGSGKE VRVPATALCV FDAHDGEVNA VQFSPGSRLL ATGGMDRRVK LWEVFGEKCE FKGSLSGSNA GITSIEFDSA GSYLLAASND FASRIWTVDD YRLRHTLTGH SGKVLSAKFL LDNARIVSGS HDRTLKLWDL RSKVCIKTVF AGSSCNDIVC TEQCVMSGHF DKKIRFWDIR SESIVREMEL LGKITALDLN PERTELLSCS RDDLLKVIDL RTNAIKQTFS APGFKCGSDW TRVVFSPDGS YVAAGSAEGS LYIWSVLTGK VEKVLSKQHS SSINAVAWSP SGSHVVSVDK GCKAVLWAQY
Genular Protein ID: 2503836512
Symbol: Q53SV2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 523
- Mass: 58272
- Checksum: 8C18FC5CF70A8461
- Sequence:
MAQLRIKHQE ELTELHKKRG ELAQLVIDLN NQMQRKDREM QMNEAKIAEC LQTISDLETE CLDLRTKLCD LERANQTLKD EYDALQITFT ALEGKLRKTT EENQELVTRW MAEKAQEANR LNAENEKDSR RRQARLQKEL AEAAKEPLPV EQDDDIEVIV DETSDHTEET SPVRAISRAA TKRLSQPAGG LLDSITNIFG RRSVSSFPVP QDNVDTHPGS GKEVRVPATA LCVFDAHDGE VNAVQFSPGS RLLATGGMDR RVKLWEVFGE KCEFKGSLSG SNAGITSIEF DSAGSYLLAA SNDFASRIWT VDDYRLRHTL TGHSGKVLSA KFLLDNARIV SGSHDRTLKL WDLRSKVCIK TVFAGSSCND IVCTEQCVMS GHFDKKIRFW DIRSESIVRE MELLGKITAL DLNPERTELL SCSRDDLLKV IDLRTNAIKQ TFSAPGFKCG SDWTRVVFSP DGSYVAAGSA EGSLYIWSVL TGKVEKVLSK QHSSSINAVA WSPSGSHVVS VDKGCKAVLW AQY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.