AVP | ENSG00000101200 | NCBI 551

Details for: AVP

Gene ID: 551

Symbol: AVP

Ensembl ID: ENSG00000101200

Description: arginine vasopressin

Associated with

Aquaporin-mediated transport
(R-HSA-445717)
Bmal1:clock,npas2 activates circadian gene expression
(R-HSA-1368108)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Circadian clock
(R-HSA-400253)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Defective avp does not bind avpr1a,b and causes neurohypophyseal diabetes insipidus (ndi)
(R-HSA-5619099)
Defective avp does not bind avpr2 and causes neurohypophyseal diabetes insipidus (ndi)
(R-HSA-9036092)
Disease
(R-HSA-1643685)
Disorders of transmembrane transporters
(R-HSA-5619115)
G alpha (q) signalling events
(R-HSA-416476)
G alpha (s) signalling events
(R-HSA-418555)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Membrane trafficking
(R-HSA-199991)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Slc-mediated transmembrane transport
(R-HSA-425407)
Slc transporter disorders
(R-HSA-5619102)
Transport of organic anions
(R-HSA-879518)
Transport of small molecules
(R-HSA-382551)
Transport of vitamins, nucleosides, and related molecules
(R-HSA-425397)
Vasopressin-like receptors
(R-HSA-388479)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Vesicle-mediated transport
(R-HSA-5653656)
Cell-cell signaling
(GO:0007267)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
(GO:0043027)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Generation of precursor metabolites and energy
(GO:0006091)
Grooming behavior
(GO:0007625)
Intracellular signal transduction
(GO:0035556)
Locomotory behavior
(GO:0007626)
Maternal aggressive behavior
(GO:0002125)
Maternal behavior
(GO:0042711)
Multicellular organismal-level water homeostasis
(GO:0050891)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of female receptivity
(GO:0007621)
Negative regulation of transmission of nerve impulse
(GO:0051970)
Neurohypophyseal hormone activity
(GO:0005185)
Neuronal dense core vesicle
(GO:0098992)
Neuropeptide hormone activity
(GO:0005184)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cellular ph reduction
(GO:0032849)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glutamate secretion
(GO:0014049)
Positive regulation of prostaglandin biosynthetic process
(GO:0031394)
Positive regulation of systemic arterial blood pressure
(GO:0003084)
Positive regulation of vasoconstriction
(GO:0045907)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Response to ethanol
(GO:0045471)
Response to nicotine
(GO:0035094)
Response to testosterone
(GO:0033574)
Secretory granule
(GO:0030141)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Social behavior
(GO:0035176)
Symbiont entry into host cell
(GO:0046718)
V1a vasopressin receptor binding
(GO:0031894)
V1b vasopressin receptor binding
(GO:0031895)
Vasoconstriction
(GO:0042310)
Water transport
(GO:0006833)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 9.1292
Cell Significance Index: -1.4200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 2.4303
Cell Significance Index: 149.0000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 1.0787
Cell Significance Index: -1.3300
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.0471
Cell Significance Index: 8.9000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.9256
Cell Significance Index: 41.9600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.8315
Cell Significance Index: 18.0200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6278
Cell Significance Index: 119.4700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4446
Cell Significance Index: 43.9800
Cell Name: hepatoblast (CL0005026)
Fold Change: 0.4007
Cell Significance Index: 6.7400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3915
Cell Significance Index: 353.5300
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.3806
Cell Significance Index: 3.9400
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.3760
Cell Significance Index: 4.7700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3140
Cell Significance Index: 16.3100
Cell Name: epithelial cell of proximal tubule segment 3 (CL4030011)
Fold Change: 0.2520
Cell Significance Index: 0.8300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.2509
Cell Significance Index: 2.3100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2248
Cell Significance Index: 36.5700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2031
Cell Significance Index: 22.0900
Cell Name: epithelial cell of proximal tubule segment 1 (CL4030009)
Fold Change: 0.1589
Cell Significance Index: 0.6500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1192
Cell Significance Index: 8.2500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0984
Cell Significance Index: 5.9100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0837
Cell Significance Index: 15.0900
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.0747
Cell Significance Index: 1.0900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0611
Cell Significance Index: 12.1300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0543
Cell Significance Index: 1.7400
Cell Name: keratocyte (CL0002363)
Fold Change: 0.0511
Cell Significance Index: 0.8100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0455
Cell Significance Index: 1.3100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0292
Cell Significance Index: 3.5900
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0286
Cell Significance Index: 0.4100
Cell Name: decidual cell (CL2000002)
Fold Change: 0.0131
Cell Significance Index: 0.2100
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.0122
Cell Significance Index: 0.1600
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.0043
Cell Significance Index: 0.0400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0037
Cell Significance Index: 0.7400
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.0035
Cell Significance Index: 0.0600
Cell Name: colonocyte (CL1000347)
Fold Change: 0.0032
Cell Significance Index: 0.0200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0013
Cell Significance Index: 0.1500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0008
Cell Significance Index: -1.4500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0011
Cell Significance Index: -0.8400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0016
Cell Significance Index: -0.0400
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0018
Cell Significance Index: -0.0800
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0020
Cell Significance Index: -1.0900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0020
Cell Significance Index: -1.2800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0022
Cell Significance Index: -1.6000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0023
Cell Significance Index: -0.0800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0023
Cell Significance Index: -1.7400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0028
Cell Significance Index: -1.5800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0029
Cell Significance Index: -1.3100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0030
Cell Significance Index: -0.3100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0031
Cell Significance Index: -0.5300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0033
Cell Significance Index: -0.1700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0035
Cell Significance Index: -1.2600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0040
Cell Significance Index: -0.5500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0048
Cell Significance Index: -0.1000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0049
Cell Significance Index: -1.4000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0049
Cell Significance Index: -0.5700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0101
Cell Significance Index: -0.2700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0109
Cell Significance Index: -0.5100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0111
Cell Significance Index: -1.3100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0127
Cell Significance Index: -0.2700
Cell Name: early promyelocyte (CL0002154)
Fold Change: -0.0141
Cell Significance Index: -0.0900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0145
Cell Significance Index: -1.1500
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0162
Cell Significance Index: -0.2300
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0178
Cell Significance Index: -0.2500
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0179
Cell Significance Index: -0.2700
Cell Name: basophil (CL0000767)
Fold Change: -0.0185
Cell Significance Index: -0.1700
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0203
Cell Significance Index: -0.2700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0223
Cell Significance Index: -1.3700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0223
Cell Significance Index: -1.1700
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0239
Cell Significance Index: -1.5400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0254
Cell Significance Index: -1.2000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0260
Cell Significance Index: -1.7500
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0281
Cell Significance Index: -0.7000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0289
Cell Significance Index: -1.6200
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.0313
Cell Significance Index: -0.4500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0316
Cell Significance Index: -0.8600
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.0320
Cell Significance Index: -0.2500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0341
Cell Significance Index: -1.2000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0371
Cell Significance Index: -1.6400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0389
Cell Significance Index: -1.2800
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.0395
Cell Significance Index: -0.4800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0396
Cell Significance Index: -1.2600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0416
Cell Significance Index: -1.1100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0430
Cell Significance Index: -1.6300
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0435
Cell Significance Index: -0.9300
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.0456
Cell Significance Index: -0.5500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0476
Cell Significance Index: -1.3700
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.0477
Cell Significance Index: -0.6600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0492
Cell Significance Index: -1.7100
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: -0.0493
Cell Significance Index: -0.5000
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.0497
Cell Significance Index: -0.8500
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0501
Cell Significance Index: -0.8300
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0512
Cell Significance Index: -1.0000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0519
Cell Significance Index: -1.5300
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0520
Cell Significance Index: -1.3000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0526
Cell Significance Index: -0.8800
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0530
Cell Significance Index: -0.7600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0530
Cell Significance Index: -1.4200
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0540
Cell Significance Index: -1.1200
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.0545
Cell Significance Index: -0.5700
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0560
Cell Significance Index: -1.4300
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0565
Cell Significance Index: -1.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Structure**: AVP is a nonapeptide hormone composed of nine amino acids, with a molecular weight of 1,368 Da. 2. **Receptor specificity**: AVP binds to two main receptor subtypes, AVPR1a and AVPR2, which are G-protein coupled receptors that activate distinct signaling pathways. 3. **Functions**: AVP regulates water reabsorption in the kidneys, blood pressure, and electrolyte balance, as well as modulating social behavior, grooming, and locomotory behavior. 4. **Expression**: AVP is expressed in various tissues, including the hypothalamus, posterior pituitary gland, kidney epithelial cells, and enterocytes. **Pathways and Functions** AVP's effects are mediated through several signaling pathways, including: 1. **Aquaporin-mediated transport**: AVP regulates water reabsorption in the kidneys by activating aquaporin-2, a water channel protein that increases water permeability in the collecting ducts. 2. **G-protein coupled receptor signaling**: AVP binds to AVPR1a and AVPR2 receptors, activating G-protein coupled signaling pathways that regulate various physiological processes, including blood pressure, electrolyte balance, and social behavior. 3. **Circadian clock regulation**: AVP is involved in regulating the circadian clock by interacting with the clock genes Bmal1 and npas2. 4. **Neurotransmitter regulation**: AVP modulates the release of neurotransmitters, such as glutamate and dopamine, which are involved in various physiological and pathological processes. **Clinical Significance** Dysregulation of AVP has been implicated in various diseases and disorders, including: 1. **Neurohypophyseal diabetes insipidus (NDI)**: A condition characterized by excessive urine production, low blood pressure, and hyponatremia, caused by defective AVP binding to AVPR1a or AVPR2 receptors. 2. **Hypertension**: AVP's vasoconstrictive effects contribute to blood pressure regulation, and dysregulation of AVP may contribute to hypertension. 3. **Social behavior disorders**: AVP's role in regulating social behavior, including grooming and locomotory behavior, has been implicated in disorders such as autism and schizophrenia. 4. **Cancer**: AVP has been shown to promote tumor growth and metastasis in certain types of cancer, such as breast and prostate cancer. In conclusion, AVP is a multifunctional neuropeptide hormone that plays a critical role in maintaining water homeostasis, regulating blood pressure, and modulating various physiological processes. Dysregulation of AVP has been implicated in various diseases and disorders, highlighting the importance of further research into the molecular mechanisms underlying AVP's functions and the development of therapeutic strategies for targeting AVP-related disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Vasopressin-neurophysin 2-copeptin

Genular Protein ID: 1447799280

Symbol: NEU2_HUMAN

Name: Vasopressin-neurophysin 2-copeptin

UniProtKB Accession Codes:

P01185 A0AV35 O14935

Database IDs:

Citations:

PubMed ID: 2991279

Title: The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line.

PubMed ID: 2991279

DOI: 10.1016/s0021-9258(17)39236-0

PubMed ID: 3768139

Title: The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation.

PubMed ID: 3768139

DOI: 10.1515/bchm3.1986.367.2.695

PubMed ID: 4065330

Title: Expression of the vasopressin and oxytocin genes in human hypothalami.

PubMed ID: 4065330

DOI: 10.1016/0014-5793(85)80069-7

PubMed ID: 1740104

Title: A missense mutation in the vasopressin-neurophysin precursor gene cosegregates with human autosomal dominant neurohypophyseal diabetes insipidus.

PubMed ID: 1740104

DOI: 10.1002/j.1460-2075.1992.tb05022.x

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 13591312

Title: On the nature of oxytocin and vasopressin from human pituitary.

PubMed ID: 13591312

DOI: 10.3181/00379727-98-24154

PubMed ID: 6574452

Title: Identification of human neurophysins: complete amino acid sequences of MSEL- and VLDV-neurophysins.

PubMed ID: 6574452

DOI: 10.1073/pnas.80.10.2839

PubMed ID: 7271787

Title: The complete sequence of a novel human pituitary glycopeptide homologous to pig posterior pituitary glycopeptide.

PubMed ID: 7271787

DOI: 10.1016/s0006-291x(81)80258-6

PubMed ID: 33713620

Title: Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.

PubMed ID: 33713620

DOI: 10.1016/j.cell.2021.02.053

PubMed ID: 8370682

Title: Familial neurohypophyseal diabetes insipidus associated with a signal peptide mutation.

PubMed ID: 8370682

DOI: 10.1210/jcem.77.3.8370682

PubMed ID: 8103767

Title: Glu-47, which forms a salt bridge between neurophysin-II and arginine vasopressin, is deleted in patients with familial central diabetes insipidus.

PubMed ID: 8103767

DOI: 10.1210/jcem.77.3.8103767

PubMed ID: 8514868

Title: Possible involvement of inefficient cleavage of preprovasopressin by signal peptidase as a cause for familial central diabetes insipidus.

PubMed ID: 8514868

DOI: 10.1172/jci116494

PubMed ID: 8045958

Title: A de novo mutation in the coding sequence for neurophysin-II (Pro24-->Leu) is associated with onset and transmission of autosomal dominant neurohypophyseal diabetes insipidus.

PubMed ID: 8045958

DOI: 10.1210/jcem.79.2.8045958

PubMed ID: 7714110

Title: Two novel mutations in the coding region for neurophysin-II associated with familial central diabetes insipidus.

PubMed ID: 7714110

DOI: 10.1210/jcem.80.4.7714110

PubMed ID: 8554046

Title: Identification of 13 new mutations in the vasopressin-neurophysin II gene in 17 kindreds with familial autosomal dominant neurohypophyseal diabetes insipidus.

PubMed ID: 8554046

PubMed ID: 9360520

Title: Autosomal dominant neurohypophyseal diabetes insipidus associated with a missense mutation encoding Gly23-->Val in neurophysin II.

PubMed ID: 9360520

DOI: 10.1210/jcem.82.11.4231

PubMed ID: 9580132

Title: Identification of a novel nonsense mutation and a missense substitution in the vasopressin-neurophysin II gene in two Spanish kindreds with familial neurohypophyseal diabetes insipidus.

PubMed ID: 9580132

DOI: 10.1210/jcem.83.3.4658

PubMed ID: 9814475

Title: Two novel mutations of the vasopressin gene associated with familial diabetes insipidus and identification of an asymptomatic carrier infant.

PubMed ID: 9814475

DOI: 10.1210/jcem.83.11.5278

PubMed ID: 10369876

Title: Autosomal recessive familial neurohypophyseal diabetes insipidus with continued secretion of mutant weakly active vasopressin.

PubMed ID: 10369876

DOI: 10.1093/hmg/8.7.1303

PubMed ID: 10487710

Title: Molecular analysis in familial neurohypophyseal diabetes insipidus: early diagnosis of an asymptomatic carrier.

PubMed ID: 10487710

DOI: 10.1210/jcem.84.9.5979

PubMed ID: 11017955

Title: Identification of two distinct mutations at the same nucleotide position, concomitantly with a novel polymorphism in the vasopressin-neurophysin II gene (AVP-NP II) in two Dutch families with familial neurohypophyseal diabetes insipidus.

PubMed ID: 11017955

PubMed ID: 11150885

Title: A novel arginine vasopressin-neurophysin II mutation causes autosomal dominant neurohypophyseal diabetes insipidus and morphologic pituitary changes.

PubMed ID: 11150885

DOI: 10.1159/000023573

PubMed ID: 10677561

Title: Familial neurohypophyseal diabetes insipidus associated with a novel mutation in the vasopressin-neurophysin II gene.

PubMed ID: 10677561

DOI: 10.3892/ijmm.5.3.229

PubMed ID: 11748489

Title: A new mutation of the arginine vasopressin-neurophysin II gene in a family with autosomal dominant neurohypophyseal diabetes insipidus.

PubMed ID: 11748489

DOI: 10.1055/s-2001-18994

PubMed ID: 11443218

Title: Familial neurohypophysial diabetes insipidus in a large Dutch kindred: effect of the onset of diabetes on growth in children and cell biological defects of the mutant vasopressin prohormone.

PubMed ID: 11443218

DOI: 10.1210/jcem.86.7.7686

PubMed ID: 11161827

Title: A missense mutation encoding cys(67) --> gly in neurophysin ii is associated with early onset autosomal dominant neurohypophyseal diabetes insipidus.

PubMed ID: 11161827

DOI: 10.1006/mgme.2000.3117

PubMed ID: 11980620

Title: Clinical and molecular analysis of three families with autosomal dominant neurohypophyseal diabetes insipidus associated with a novel and recurrent mutations in the vasopressin-neurophysin II gene.

PubMed ID: 11980620

DOI: 10.1530/eje.0.1460649

PubMed ID: 12012274

Title: Identification of a novel mutation in the arginine vasopressin-neurophysin II gene in familial central diabetes insipidus.

PubMed ID: 12012274

DOI: 10.1055/s-2002-29091

PubMed ID: 12107248

Title: Autosomal dominant neurohypophyseal diabetes insipidus due to substitution of histidine for tyrosine-2 in the vasopressin moiety of the hormone precursor.

PubMed ID: 12107248

DOI: 10.1210/jcem.87.7.8677

PubMed ID: 12359138

Title: A missense mutation encoding Cys73Phe in neurophysin II is associated with autosomal dominant neurohypophyseal diabetes insipidus.

PubMed ID: 12359138

DOI: 10.1016/s1096-7192(02)00118-x

PubMed ID: 12519420

Title: A signal peptide mutation of the arginine vasopressin gene in monozygotic twins.

PubMed ID: 12519420

DOI: 10.1046/j.1365-2265.2003.01667.x

PubMed ID: 14510916

Title: Progressive decline of vasopressin secretion in familial autosomal dominant neurohypophyseal diabetes insipidus presenting a novel mutation in the vasopressin-neurophysin II gene.

PubMed ID: 14510916

DOI: 10.1046/j.1365-2265.2003.01834.x

PubMed ID: 12931042

Title: A new missense mutation of the vasopressin-neurophysin II gene in a family with neurohypophyseal diabetes insipidus.

PubMed ID: 12931042

DOI: 10.1159/000072526

PubMed ID: 15538939

Title: Identification of a novel mutation in the arginine vasopressin-neurophysin II gene affecting the sixth intrachain disulfide bridge of the neurophysin II moiety.

PubMed ID: 15538939

DOI: 10.1530/eje.0.1510605

PubMed ID: 14673472

Title: Six novel mutations in the arginine vasopressin gene in 15 kindreds with autosomal dominant familial neurohypophyseal diabetes insipidus give further insight into the pathogenesis.

PubMed ID: 14673472

DOI: 10.1038/sj.ejhg.5201086

PubMed ID: 18174156

Title: Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides.

PubMed ID: 18174156

DOI: 10.1074/jbc.m706477200

Sequence Information:

Length: 164
Mass: 17325
Checksum: 8F5EF9834700B9AE
Sequence:

MPDTMLPACF LGLLAFSSAC YFQNCPRGGK RAMSDLELRQ CLPCGPGGKG RCFGPSICCA 
DELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAA FGVCCNDESC VTEPECREGF 
HRRARASDRS NATQLDGPAG ALLLRLVQLA GAPEPFEPAQ PDAY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AVP

Associated with

Cells (max top 100)

Other Information

The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line. PubMed ID: 2991279

The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation. PubMed ID: 3768139

Expression of the vasopressin and oxytocin genes in human hypothalami. PubMed ID: 4065330

A missense mutation in the vasopressin-neurophysin precursor gene cosegregates with human autosomal dominant neurohypophyseal diabetes insipidus. PubMed ID: 1740104

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

On the nature of oxytocin and vasopressin from human pituitary. PubMed ID: 13591312

Identification of human neurophysins: complete amino acid sequences of MSEL- and VLDV-neurophysins. PubMed ID: 6574452

The complete sequence of a novel human pituitary glycopeptide homologous to pig posterior pituitary glycopeptide. PubMed ID: 7271787

Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system. PubMed ID: 33713620

Familial neurohypophyseal diabetes insipidus associated with a signal peptide mutation. PubMed ID: 8370682

Glu-47, which forms a salt bridge between neurophysin-II and arginine vasopressin, is deleted in patients with familial central diabetes insipidus. PubMed ID: 8103767

Possible involvement of inefficient cleavage of preprovasopressin by signal peptidase as a cause for familial central diabetes insipidus. PubMed ID: 8514868

A de novo mutation in the coding sequence for neurophysin-II (Pro24--&gt;Leu) is associated with onset and transmission of autosomal dominant neurohypophyseal diabetes insipidus. PubMed ID: 8045958

Two novel mutations in the coding region for neurophysin-II associated with familial central diabetes insipidus. PubMed ID: 7714110

Identification of 13 new mutations in the vasopressin-neurophysin II gene in 17 kindreds with familial autosomal dominant neurohypophyseal diabetes insipidus. PubMed ID: 8554046

Autosomal dominant neurohypophyseal diabetes insipidus associated with a missense mutation encoding Gly23--&gt;Val in neurophysin II. PubMed ID: 9360520

Identification of a novel nonsense mutation and a missense substitution in the vasopressin-neurophysin II gene in two Spanish kindreds with familial neurohypophyseal diabetes insipidus. PubMed ID: 9580132

Two novel mutations of the vasopressin gene associated with familial diabetes insipidus and identification of an asymptomatic carrier infant. PubMed ID: 9814475

Autosomal recessive familial neurohypophyseal diabetes insipidus with continued secretion of mutant weakly active vasopressin. PubMed ID: 10369876

Molecular analysis in familial neurohypophyseal diabetes insipidus: early diagnosis of an asymptomatic carrier. PubMed ID: 10487710

Identification of two distinct mutations at the same nucleotide position, concomitantly with a novel polymorphism in the vasopressin-neurophysin II gene (AVP-NP II) in two Dutch families with familial neurohypophyseal diabetes insipidus. PubMed ID: 11017955

A novel arginine vasopressin-neurophysin II mutation causes autosomal dominant neurohypophyseal diabetes insipidus and morphologic pituitary changes. PubMed ID: 11150885

Familial neurohypophyseal diabetes insipidus associated with a novel mutation in the vasopressin-neurophysin II gene. PubMed ID: 10677561

A new mutation of the arginine vasopressin-neurophysin II gene in a family with autosomal dominant neurohypophyseal diabetes insipidus. PubMed ID: 11748489

Familial neurohypophysial diabetes insipidus in a large Dutch kindred: effect of the onset of diabetes on growth in children and cell biological defects of the mutant vasopressin prohormone. PubMed ID: 11443218

A missense mutation encoding cys(67) --&gt; gly in neurophysin ii is associated with early onset autosomal dominant neurohypophyseal diabetes insipidus. PubMed ID: 11161827

Clinical and molecular analysis of three families with autosomal dominant neurohypophyseal diabetes insipidus associated with a novel and recurrent mutations in the vasopressin-neurophysin II gene. PubMed ID: 11980620

Identification of a novel mutation in the arginine vasopressin-neurophysin II gene in familial central diabetes insipidus. PubMed ID: 12012274

Autosomal dominant neurohypophyseal diabetes insipidus due to substitution of histidine for tyrosine-2 in the vasopressin moiety of the hormone precursor. PubMed ID: 12107248

A missense mutation encoding Cys73Phe in neurophysin II is associated with autosomal dominant neurohypophyseal diabetes insipidus. PubMed ID: 12359138

A signal peptide mutation of the arginine vasopressin gene in monozygotic twins. PubMed ID: 12519420

Progressive decline of vasopressin secretion in familial autosomal dominant neurohypophyseal diabetes insipidus presenting a novel mutation in the vasopressin-neurophysin II gene. PubMed ID: 14510916

A new missense mutation of the vasopressin-neurophysin II gene in a family with neurohypophyseal diabetes insipidus. PubMed ID: 12931042

Identification of a novel mutation in the arginine vasopressin-neurophysin II gene affecting the sixth intrachain disulfide bridge of the neurophysin II moiety. PubMed ID: 15538939

Six novel mutations in the arginine vasopressin gene in 15 kindreds with autosomal dominant familial neurohypophyseal diabetes insipidus give further insight into the pathogenesis. PubMed ID: 14673472

Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides. PubMed ID: 18174156