PIWIL2 | ENSG00000197181 | NCBI 55124

Details for: PIWIL2

Gene ID: 55124

Symbol: PIWIL2

Ensembl ID: ENSG00000197181

Description: piwi like RNA-mediated gene silencing 2

Associated with

Gene expression (transcription)
(R-HSA-74160)
Gene silencing by rna
(R-HSA-211000)
Piwi-interacting rna (pirna) biogenesis
(R-HSA-5601884)
Chromatoid body
(GO:0033391)
Cytoplasm
(GO:0005737)
Dense body
(GO:0097433)
Germ-line stem cell population maintenance
(GO:0030718)
Meiotic cell cycle
(GO:0051321)
Metal ion binding
(GO:0046872)
Mrna binding
(GO:0003729)
Negative regulation of circadian rhythm
(GO:0042754)
Nucleus
(GO:0005634)
Oogenesis
(GO:0048477)
Perinucleolar chromocenter
(GO:0010370)
Pet complex
(GO:1990923)
P granule
(GO:0043186)
Pi-body
(GO:0071546)
Pirna-mediated retrotransposon silencing by heterochromatin formation
(GO:0141006)
Pirna binding
(GO:0034584)
Polysome binding
(GO:1905538)
Positive regulation of meiosis i
(GO:0060903)
Positive regulation of translation
(GO:0045727)
Protein binding
(GO:0005515)
Regulatory ncrna-mediated gene silencing
(GO:0031047)
Retrotransposon silencing by heterochromatin formation
(GO:0141005)
Retrotransposon silencing by mrna destabilization
(GO:0141008)
Rhythmic process
(GO:0048511)
Rna endonuclease activity
(GO:0004521)
Secondary pirna processing
(GO:0140965)
Sirna-mediated retrotransposon silencing by heterochromatin formation
(GO:0141007)
Spermatogenesis
(GO:0007283)

Other Information

Proteins

Piwi-like protein 2

Genular Protein ID: 118428238

Symbol: PIWL2_HUMAN

Name: Piwi-like protein 2

UniProtKB Accession Codes:

Q8TC59 A8K4S3 A8K8S5 B0AZN9 B0AZP2 B4DR22 E7ECA4 Q96SW6 Q9NW28

Database IDs:

Citations:

PubMed ID: 12906857

Title: Identification of eight members of the Argonaute family in the human genome.

PubMed ID: 12906857

DOI: 10.1016/s0888-7543(03)00129-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16377660

Title: Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway.

PubMed ID: 16377660

DOI: 10.1093/hmg/ddi430

PubMed ID: 28903391

Title: Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.

PubMed ID: 28903391

DOI: 10.18632/oncotarget.18973

PubMed ID: 21193640

Title: Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains.

PubMed ID: 21193640

DOI: 10.1073/pnas.1017762108

Sequence Information:

Length: 973
Mass: 109849
Checksum: C44398136B144CA0
Sequence:

MDPFRPSFRG QSPIHPSQCQ AVRMPGCWPQ ASKPLDPALG RGAPAGRGHV FGKPEEPSTQ 
RGPAQRESVG LVSMFRGLGI ETVSKTPLKR EMLPSGRGIL GRGLSANLVR KDREELSPTF 
WDPKVLAAGD SKMAETSVGW SRTLGRGSSD ASLLPLGRAA GGISREVDKP PCTFSTPSRG 
PPQLSSPPAL PQSPLHSPDR PLVLTVEHKE KELIVKQGSK GTPQSLGLNL VKIQCHNEAV 
YQYHVTFSPN VECKSMRFGM LKDHQAVTGN VTAFDGSILY LPVKLQQVLE LKSQRKTDSA 
EISIKIQMTK ILEPCSDLCI PFYNVVFRRV MKLLDMKLVG RNFYDPTSAM VLQQHRLQIW 
PGYAASIRRT DGGLFLLADV SHKVIRNDCV LDVMHAIYQQ NKEHFQDECT KLLVGNIVIT 
RYNNRTYRID DVDWNKTPKD SFTMSDGKEI TFLEYYSKNY GITVKEEDQP LLIHRPSERQ 
DNHGMLLKGE ILLLPELSFM TGIPEKMKKD FRAMKDLAQQ INLSPKQHHS ALECLLQRIA 
KNEAATNELM RWGLRLQKDV HKIEGRVLPM ERINLKNTSF ITSQELNWVK EVTRDPSILT 
IPMHFWALFY PKRAMDQARE LVNMLEKIAG PIGMRMSPPA WVELKDDRIE TYVRTIQSTL 
GAEGKIQMVV CIIMGPRDDL YGAIKKLCCV QSPVPSQVVN VRTIGQPTRL RSVAQKILLQ 
INCKLGGELW GVDIPLKQLM VIGMDVYHDP SRGMRSVVGF VASINLTLTK WYSRVVFQMP 
HQEIVDSLKL CLVGSLKKFY EVNHCLPEKI VVYRDGVSDG QLKTVANYEI PQLQKCFEAF 
ENYQPKMVVF VVQKKISTNL YLAAPQNFVT PTPGTVVDHT ITSCEWVDFY LLAHHVRQGC 
GIPTHYVCVL NTANLSPDHM QRLTFKLCHM YWNWPGTIRV PAPCKYAHKL AFLSGHILHH 
EPAIQLCENL FFL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PIWIL2

Associated with

Other Information

Identification of eight members of the Argonaute family in the human genome. PubMed ID: 12906857

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway. PubMed ID: 16377660

Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK. PubMed ID: 28903391