Details for: WRAP53
Associated with
Other Information
Genular Protein ID: 935270599
Symbol: TCAB1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19250907
Title: Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage.
PubMed ID: 19250907
PubMed ID: 19285445
Title: A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles.
PubMed ID: 19285445
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19179534
Title: A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis.
PubMed ID: 19179534
PubMed ID: 20351177
Title: Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo.
PubMed ID: 20351177
DOI: 10.1128/mcb.00151-10
PubMed ID: 21072240
Title: WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies.
PubMed ID: 21072240
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22547674
Title: Telomerase recruitment requires both TCAB1 and Cajal bodies independently.
PubMed ID: 22547674
DOI: 10.1128/mcb.00379-12
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25467444
Title: Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.
PubMed ID: 25467444
PubMed ID: 25512560
Title: The scaffold protein WRAP53beta orchestrates the ubiquitin response critical for DNA double-strand break repair.
PubMed ID: 25512560
PubMed ID: 24318571
Title: Catalytically active telomerase holoenzyme is assembled in the dense fibrillar component of the nucleolus during S phase.
PubMed ID: 24318571
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26170453
Title: Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange across the Cell Cycle.
PubMed ID: 26170453
PubMed ID: 26734725
Title: The proximity ligation assay reveals that at DNA double-strand breaks WRAP53beta associates with gammaH2AX and controls interactions between RNF8 and MDC1.
PubMed ID: 26734725
PubMed ID: 27525486
Title: Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies.
PubMed ID: 27525486
DOI: 10.7554/elife.18221
PubMed ID: 27715493
Title: Phosphorylation of the Cajal body protein WRAP53beta by ATM promotes its involvement in the DNA damage response.
PubMed ID: 27715493
PubMed ID: 28607398
Title: Epstein-Barr virus-induced up-regulation of TCAB1 is involved in the DNA damage response in nasopharyngeal carcinoma.
PubMed ID: 28607398
PubMed ID: 29804836
Title: An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1.
PubMed ID: 29804836
PubMed ID: 29695869
Title: Cryo-EM structure of substrate-bound human telomerase holoenzyme.
PubMed ID: 29695869
PubMed ID: 21205863
Title: Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita.
PubMed ID: 21205863
DOI: 10.1101/gad.2006411
PubMed ID: 21602826
Title: Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.
PubMed ID: 21602826
DOI: 10.1038/nature10084
Sequence Information:
- Length: 548
- Mass: 59309
- Checksum: 4687517268A813B5
- Sequence:
MKTLETQPLA PDCCPSDQDP APAHPSPHAS PMNKNADSEL MPPPPERGDP PRLSPDPVAG SAVSQELREG DPVSLSTPLE TEFGSPSELS PRIEEQELSE NTSLPAEEAN GSLSEEEANG PELGSGKAME DTSGEPAAED EGDTAWNYSF SQLPRFLSGS WSEFSTQPEN FLKGCKWAPD GSCILTNSAD NILRIYNLPP ELYHEGEQVE YAEMVPVLRM VEGDTIYDYC WYSLMSSAQP DTSYVASSSR ENPIHIWDAF TGELRASFRA YNHLDELTAA HSLCFSPDGS QLFCGFNRTV RVFSTARPGR DCEVRATFAK KQGQSGIISC IAFSPAQPLY ACGSYGRSLG LYAWDDGSPL ALLGGHQGGI THLCFHPDGN RFFSGARKDA ELLCWDLRQS GYPLWSLGRE VTTNQRIYFD LDPTGQFLVS GSTSGAVSVW DTDGPGNDGK PEPVLSFLPQ KDCTNGVSLH PSLPLLATAS GQRVFPEPTE SGDEGEELGL PLLSTRHVHL ECRLQLWWCG GAPDSSIPDD HQGEKGQGGT EGGVGELI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.