CDCA8 | ENSG00000134690 | NCBI 55143

Details for: CDCA8

Gene ID: 55143

Symbol: CDCA8

Ensembl ID: ENSG00000134690

Description: cell division cycle associated 8

Associated with

Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Metabolism of proteins
(R-HSA-392499)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Post-translational protein modification
(R-HSA-597592)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of dna replication proteins
(R-HSA-4615885)
Chromocenter
(GO:0010369)
Chromosome, centromeric region
(GO:0000775)
Chromosome organization
(GO:0051276)
Chromosome passenger complex
(GO:0032133)
Cytosol
(GO:0005829)
Intercellular bridge
(GO:0045171)
Microtubule cytoskeleton
(GO:0015630)
Midbody
(GO:0030496)
Mitotic cell cycle
(GO:0000278)
Mitotic cytokinesis
(GO:0000281)
Mitotic metaphase chromosome alignment
(GO:0007080)
Mitotic sister chromatid segregation
(GO:0000070)
Mitotic spindle assembly
(GO:0090307)
Mitotic spindle midzone assembly
(GO:0051256)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Positive regulation of attachment of mitotic spindle microtubules to kinetochore
(GO:1902425)
Positive regulation of mitotic cell cycle spindle assembly checkpoint
(GO:0090267)
Positive regulation of mitotic cytokinesis
(GO:1903490)
Positive regulation of mitotic sister chromatid separation
(GO:1901970)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Spindle midzone
(GO:0051233)

Other Information

Proteins

Borealin

Genular Protein ID: 3565887676

Symbol: BOREA_HUMAN

Name: Borealin

UniProtKB Accession Codes:

Q53HL2 D3DPT4 Q53HN1 Q96AM3 Q9NVW5

Database IDs:

Citations:

PubMed ID: 12188893

Title: Drug target discovery by gene expression analysis: cell cycle genes.

PubMed ID: 12188893

DOI: 10.2174/1568009013334241

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15260989

Title: The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly.

PubMed ID: 15260989

DOI: 10.1016/j.cell.2004.06.026

PubMed ID: 15249581

Title: Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.

PubMed ID: 15249581

DOI: 10.1083/jcb.200404001

PubMed ID: 15561729

Title: Proteome analysis of the human mitotic spindle.

PubMed ID: 15561729

DOI: 10.1074/mcp.m400158-mcp200

PubMed ID: 16239925

Title: Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody.

PubMed ID: 16239925

DOI: 10.1038/sj.embor.7400562

PubMed ID: 16427043

Title: Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer.

PubMed ID: 16427043

DOI: 10.1016/j.yexcr.2005.12.015

PubMed ID: 16291752

Title: Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis.

PubMed ID: 16291752

DOI: 10.1074/jbc.m508773200

PubMed ID: 16436504

Title: Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres.

PubMed ID: 16436504

DOI: 10.1091/mbc.e05-08-0727

PubMed ID: 16571674

Title: Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of borealin, survivin, and the N-terminal domain of INCENP.

PubMed ID: 16571674

DOI: 10.1091/mbc.e05-12-1133

PubMed ID: 16547492

Title: Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown.

PubMed ID: 16547492

DOI: 10.1038/sj.onc.1209499

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18591255

Title: A survivin-ran complex regulates spindle formation in tumor cells.

PubMed ID: 18591255

DOI: 10.1128/mcb.02039-07

PubMed ID: 18243099

Title: Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.

PubMed ID: 18243099

DOI: 10.1016/j.cell.2007.11.046

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 18946085

Title: RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin.

PubMed ID: 18946085

DOI: 10.1091/mbc.e08-05-0511

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20739936

Title: Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation.

PubMed ID: 20739936

DOI: 10.1038/nature09390

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 17956729

Title: Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.

PubMed ID: 17956729

DOI: 10.1016/j.cell.2007.07.045

PubMed ID: 19530738

Title: Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation.

PubMed ID: 19530738

DOI: 10.1021/bi900530v

Sequence Information:

Length: 280
Mass: 31323
Checksum: 519978A7C295C571
Sequence:

MAPRKGSSRV AKTNSLRRRK LASFLKDFDR EVEIRIKQIE SDRQNLLKEV DNLYNIEILR 
LPKALREMNW LDYFALGGNK QALEEAATAD LDITEINKLT AEAIQTPLKS AKTRKVIQVD 
EMIVEEEEEE ENERKNLQTA RVKRCPPSKK RTQSIQGKGK GKRSSRANTV TPAVGRLEVS 
MVKPTPGLTP RFDSRVFKTP GLRTPAAGER IYNISGNGSP LADSKEIFLT VPVGGGESLR 
LLASDLQRHS IAQLDPEALG NIKKLSNRLA QICSSIRTHK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDCA8

Associated with

Other Information

Drug target discovery by gene expression analysis: cell cycle genes. PubMed ID: 12188893

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. PubMed ID: 15260989

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. PubMed ID: 15249581

Proteome analysis of the human mitotic spindle. PubMed ID: 15561729

Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. PubMed ID: 16239925

Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. PubMed ID: 16427043

Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis. PubMed ID: 16291752

Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres. PubMed ID: 16436504

Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of borealin, survivin, and the N-terminal domain of INCENP. PubMed ID: 16571674

Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown. PubMed ID: 16547492

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A survivin-ran complex regulates spindle formation in tumor cells. PubMed ID: 18591255

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. PubMed ID: 18243099

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin. PubMed ID: 18946085

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation. PubMed ID: 20739936

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. PubMed ID: 17956729

Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation. PubMed ID: 19530738